不同胰岛素抵抗指数对高血压人群糖尿病风险的预测效果
Predictive Effects of Different Insulin Resistance Indexes on Diabetes Risk in Hypertensive Population
查看参考文献32篇
王涛
1,2
余超
1,2
俞国涛
3
周伟
1,2
祝玲娟
1,2
黄晓
1,2,4
鲍慧慧
1,2,4
程晓曙
1,2,4
*
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文摘
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目的探讨在高血压人群中不同胰岛素抵抗指数[血清甘油三酯与葡萄糖乘积指数(TyG)、甘油三酯(TG)/高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗代谢指数(METS-IR)]以及联合两指数预测糖尿病风险的效果。方法于2018年3至8月,对江西省婺源县居民进行高血压普查。通过面对面个人问卷调查、体格测量及实验室检查等方式收集患者信息,按是否患有糖尿病分组,进行组间基本特征比较。应用Logistic回归模型分析不同胰岛素抵抗指数与糖尿病的关系,并用受试者工作特征曲线下面积比较各指数及联合指数预测糖尿病的效果。结果纳入14 222例高血压患者,平均年龄(63.8 ±9.4)岁,其中糖尿病患者2616例。与非糖尿病高血压人群相比,糖尿病人群的TyG(t = 50.323, P < 0.001)、TG/ HDL-C(Z =17.325, P <0.001)、METS-IR(t =28.839, P <0.001)均较高。多因素分析显示,各胰岛素抵抗指数与糖尿病风险均呈正相关。各胰岛素指数的受试者工作特征曲线下面积从大到小依次为TyG(0.770)、METS-IR(0.673)、TG/ HDL-C(0.620),并且TyG与TG/ HDL-C(Z =42.325, P <0.001)、TyG与METS-IR(Z =17.517, P <0.001)、TG/ HDLC与METS-IR(Z =10.502, P <0.001)两两之间比较受试者工作特征曲线下面积差异均有统计学意义。结论不同胰岛素抵抗指数升高可增加糖尿病风险。相较于TG/ HDL-C及METS-IR, TyG指数及联合指数预测糖尿病效果更好。 |
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其他语种文摘
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Objective To explore the roles of different insulin resistance indexes [triglyceride-glucose(TyG), triglyceride(TG)/ high-density lipoprotein cholesterol(HDL-C), and metabolic score for insulin resistance(METSIR)]and combinations of two indexes in predicting diabetes risk in hypertensive population. Methods The survey of hypertension was conducted for the residents in Wuyuan county, Jiangxi province from March to August in 2018. The basic information of hypertensive residents was collected by interview. Blood was drawn on an empty stomach in the morning and physical measurements were carried out. Logistic regression model was employed to analyze the relationship between different insulin resistance indexes and diabetes, and the area under the receiver operating characteristic curve was used for evaluating the predictive effects of each index on diabetes risk. Results A total of 14 222 hypertensive patients with an average age of(63.8 ±9.4)years old were included in this study, including 2616 diabetic patients. The diabetic hypertensive population had higher TyG(t = 50.323, P < 0.001), TG/ HDL-C(Z =17.325, P <0.001), and METS-IR(t =28.839, P <0.001)than the non-diabetic hypertensive population. Multivariate analysis showed that each insulin resistance index was positively correlated with diabetes risk. The area under curve of each insulin index was in a descending order of TyG(0.770)>METS-IR(0.673)>TG/ HDL-C(0.620). The difference in the area under curve between two indexes was statistically significant [TyG vs. TG/ HDL-C(Z =42.325, P <0.001); TyG vs. METS-IR(Z =17.517, P < 0.001); METS-IR vs. TG/ HDL-C(Z =10.502, P <0.001)]. Conclusions Elevated insulin resistance indexes can increase the risk of diabetes. TyG and the combination of indexes outperform TG/ HDL-C and METS-IR in the prediction of diabetes. |
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来源
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中国医学科学院学报
,2023,45(2):206-212 【核心库】
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DOI
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10.3881/j.issn.1000-503X.15127
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关键词
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高血压
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胰岛素抵抗指数
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糖尿病
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地址
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1.
南昌大学第二附属医院心血管病防治中心, 南昌, 330006
2.
江西省心血管疾病临床医学研究中心, 江西省心血管疾病临床医学研究中心, 南昌, 330006
3.
婺源县江湾镇中心卫生院, 江西, 婺源, 333200
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南昌大学第二附属医院心血管内科, 南昌, 330006
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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内科学 |
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基金
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江西省创新驱动"5511"工程
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南昌大学第二附属医院基金
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文献收藏号
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CSCD:7469995
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