人烟碱代谢相关基因硏究进展
Research progress of the nicotine metabolism related genes in humans
查看参考文献105篇
|
文摘
|
烟碱是烟草制品中主要的成瘾性物质。人体中烟碱药代动力学表现出极大的个体和种族差异,主要归因于烟碱代谢相关基因的多态性。揭示这种多态性对阐明个体对烟碱的耐受性、烟碱或吸烟相关疾病的易感性及烟碱或吸烟相关症状临床表现的多样性具有重要意义。人体中烟碱经多种代谢途径进行广泛地代谢,包括以CYP2A6为代表的碳氧化代谢途径,以及氮氧化、醛氧化和葡萄糖苷酸化作用等代谢途径。现对各烟碱代谢酶的基本性质、基因多态性、烟碱代谢活性及其诱导调控的可能机制进行综述。 |
|
其他语种文摘
|
Nicotine is an important addictive substance in tobacco products. In humans, nicotine pharmacokinetics showed great interindividual and interethnic differences, mainly due to genetic polymorphism of nicotine metabolism related genes. Revealling this polymorphism is significant for clarifying individual tolerance to nicotine, susceptibility to nicotine or smoking related diseases, the diversity of clinical manifestations of nicotine or smoking related symptoms. In human nicotine is extensively metabolized via multiple pathways that are catalyzed by genetically variable enzymes, including the carbon oxidative metabolism pathway represented by CYP2A6, as well as other metabolic pathways of nitrogen oxidation, aldehyde oxidation and glucuronidation. In this paper, the basic properties of various enzymes involved in nicotine metabolism, gene polymorphism, the possible mechanism of nicotine metabolism activity and its regulation mechanism were reviewed. |
|
来源
|
生命科学
,2016,28(11):1360-1369 【扩展库】
|
|
DOI
|
10.13376/j.cbls/2016175
|
|
关键词
|
烟碱
;
代谢酶
;
基因多态性
;
诱导调控
|
|
地址
|
1.
国家烟草质量监督检验中心, 郑州, 450001
2.
中国科学院合肥物质科学研究院, 合肥, 230031
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1004-0374 |
|
学科
|
分子生物学;药学 |
|
基金
|
国家局重点项目
|
|
文献收藏号
|
CSCD:5856438
|
参考文献 共
105
共6页
|
|
1.
Benowitz N L. Nicotine renal excretion rate influences nicotine intake during cigarette smoking.
J Pharmacol Exp Ther,1985,234:153-155
|
CSCD被引
1
次
|
|
|
|
|
2.
Benowitz N L. Metabolism of nicotine to cotinine studied by a dual stable isotope method.
Clin Pharmacol Ther,1994,56:483-493
|
CSCD被引
4
次
|
|
|
|
|
3.
Tanner J A. Pharmacogenetics of nicotine and associated smoking behaviors.
Curr Top Behav Neurosci,2015,23:37-86
|
CSCD被引
1
次
|
|
|
|
|
4.
Koudsi N A. The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence.
J Pediat Biochem,2010,1:105-123
|
CSCD被引
1
次
|
|
|
|
|
5.
Mwenifumbo J C. Molecular genetics of nicotine metabolism.
Handb Exp Pharmacol,2009,192:235-259
|
CSCD被引
3
次
|
|
|
|
|
6.
Shimada T. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals:studies with liver microsomes of 30 Japanese and 30 Caucasians.
J Pharmacol Exp Ther,1994,270:414-423
|
CSCD被引
40
次
|
|
|
|
|
7.
Shah R R. CYP450 genotype and pharmacogenetic association studies:a critical appraisal.
Pharmacogenomics,2016,17:259-275
|
CSCD被引
4
次
|
|
|
|
|
8.
Nakajima M. Role of human cytochrome P4502A6 in C-oxidation of nicotine.
Drug Metab Dispos,1996,24:1212-1217
|
CSCD被引
2
次
|
|
|
|
|
9.
Audrain-McGovern J. The role of CYP2A6 in the emergence of nicotine dependence in adolescents.
Pediatrics,2007,119:e264-e274
|
CSCD被引
1
次
|
|
|
|
|
10.
Higashi E. Human CYP2A6 is induced by estrogen via estrogen receptor.
Drug Metab Dispos,2007,35:1935-1941
|
CSCD被引
5
次
|
|
|
|
|
11.
Messina E S. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
J Pharmacol Exp Ther,1997,282:1608-1614
|
CSCD被引
8
次
|
|
|
|
|
12.
Benowitz N L. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
Clin Pharmacol Ther,2006,80:457-467
|
CSCD被引
1
次
|
|
|
|
|
13.
Nakajima M. Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.
Clin Pharmacol Ther,2006,80:282-297
|
CSCD被引
5
次
|
|
|
|
|
14.
Yamano S. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.
Biochemistry,1990,29:1322-1329
|
CSCD被引
5
次
|
|
|
|
|
15.
Pitarque M. A nicotine C-oxidase gene (CYP2A 6) polymorphism important for promoter activity.
Hum Mutat,2004,23:258-266
|
CSCD被引
2
次
|
|
|
|
|
16.
Rao Y. Duplications and defects in the CYP2A6 gene:identification, genotyping, and in vivo effects on smoking.
Mol Pharmacol,2000,58:747-755
|
CSCD被引
8
次
|
|
|
|
|
17.
Fukami T. A novel duplication type of CYP2A6 gene in African-American population.
Drug Metab Dispos,2007,35:515-520
|
CSCD被引
1
次
|
|
|
|
|
18.
Mwenifumbo J C. Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.
Hum Mutat,2008,29:679-688
|
CSCD被引
2
次
|
|
|
|
|
19.
Oscarson M. Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase.
FEBS Lett,1998,438:201-205
|
CSCD被引
3
次
|
|
|
|
|
20.
Xu C. An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.
Biochem Biophys Res Commun,2002,290:318-324
|
CSCD被引
8
次
|
|
|
|
|
了解气象卫星更多信息，请访问