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Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel

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文摘 Background: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P< 0.001). ROC-curve analysis demonstrated that LTA (area under the curve [AUC]: 0.677; 95% confidence interval [CI]: 0.643-0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI: 0.650-0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P < 0.001), and by TEG (6.7% vs. 2.6%; P < 0.001). Kaplan-Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI.
来源 Chinese Medical Journal ,2015,128(6):774-779 【核心库】
DOI 10.4103/0366-6999.152611
关键词 Clopidogrel ; High On-treatment Platelet Reactivity ; Light Transmittance Aggregometry ; Thrombelastography
地址

1. Department of Cardiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, 100037  

2. Department of Cardiology, Institute of Cardiovascular Research of People's Liberation Army, Shenyang Northern Hospital, Liaoning, Shenyang, 110840  

3. Department of Cardiology, Centre for Coronary Heart Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Beijing, 100037

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 内科学
基金 supported by grants from the National Research Key Project of the Twelfth Five-year Plan of Republic of China ;  国家自然科学基金 ;  National Special Fund for Healthcare Research in the Public Interests of China
文献收藏号 CSCD:5363387

参考文献 共 27 共2页

1.  Mehta S R. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study. Lancet,2001,358:527-533 CSCD被引 80 次    
2.  Steinhubl S R. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. JAMA,2002,288:2411-2420 CSCD被引 88 次    
3.  Matetzky S. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation,2004,109:3171-3175 CSCD被引 52 次    
4.  Price M J. Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation. Eur Heart J,2008,29:992-1000 CSCD被引 12 次    
5.  Bonello L. Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study. J Am Coll Cardiol,2008,51:1404-1411 CSCD被引 24 次    
6.  Bliden K P. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: Is the current antiplatelet therapy adequate?. J Am Coll Cardiol,2007,49:657-666 CSCD被引 25 次    
7.  Gurbel P A. Platelet function monitoring in patients with coronary artery disease. J Am Coll Cardiol,2007,50:1822-1834 CSCD被引 30 次    
8.  Bonello L. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol,2010,56:919-933 CSCD被引 39 次    
9.  Breet N J. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA,2010,303:754-762 CSCD被引 41 次    
10.  Parodi G. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI. JAMA,2011,306:1215-1223 CSCD被引 10 次    
11.  Gurbel P A. Platelet reactivity in patients and recurrent events post-stenting: Results of the PREPARE POST-STENTING Study. J Am Coll Cardiol,2005,46:1820-1826 CSCD被引 27 次    
12.  Krishna V. Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents? the role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven. Circulation,2012,125:1288-1303 CSCD被引 1 次    
13.  Sibbing D. High platelet reactivity and clinical outcome-fact and fiction. Thromb Haemost,2011,106:191-202 CSCD被引 3 次    
14.  Kim I S. Correlation of high post-treatment platelet reactivity assessed by light transmittance aggregometry and the VerifyNow P2Y12 assay. J Thromb Thrombolysis,2010,30:486-495 CSCD被引 1 次    
15.  Park Y. The concordance and correlation of measurements by multiple electrode and light transmittance aggregometries based on the pre-defined cutoffs of high and low on-treatment platelet reactivity. Platelets,2012,23:290-298 CSCD被引 2 次    
16.  Hobson A R. A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography. Platelets,2007,18:497-505 CSCD被引 10 次    
17.  Steg P G. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J,2012,33:2569-2619 CSCD被引 128 次    
18.  Cutlip D E. Clinical end points in coronary stent trials: A case for standardized definitions. Circulation,2007,115:2344-2351 CSCD被引 170 次    
19.  Hochholzer W. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol,2006,48:1742-1750 CSCD被引 13 次    
20.  Michelson A D. Platelet function testing in cardiovascular diseases. Circulation,2004,110:e489-e493 CSCD被引 11 次    
引证文献 8 篇

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2 Nie Xiaoyan The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome Journal of Chinese Pharmaceutical Sciences,2016,25(11):838-845
CSCD被引 0 次

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