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Temporal effect of local hyperthermia on murine contact hypersensitivity

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文摘 Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43°C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. Methods Local hyperthermia was applied to murine dorsal skin 3 days prior to, concurrent with, or 2 days post sensitization with fluorescein isothiocyanate (FITC) in BALB/c mice. Local hyperthermia temperatures at 37°C, 39°C, 41°C and 43°C were applied to mouse dorsal skin and the severity of CHS was calculated by measuring the swelling response of the challenged ears. Results Local hyperthermia at 39°C, 41°C and 43°C prior to sensitization reduced the severity of CHS, as compared with that at 37°C. The suppression of CHS was temperature dependant in that higher temperature had a stronger effect. On the contrary, the hyperthermia treatments, either concurrent with or post-sensitization, resulted in an enhanced temperature-dependant ear swelling response. Conclusions The severity of murine CHS could be influenced by local hyperthermia at the sensitization stage in a temperature dependant manner. The temporal effect of local hyperthermia suggested a novel factor in interpreting the severity of allergic contact dermatitis.
来源 Chinese Medical Journal ,2013,126(8):1555-1559 【核心库】
DOI 10.3760/cma.j.issn.0366-6999.20123030
关键词 fever ; dermatitis, contact ; Langerhans cells ; immunization
地址

1. Department of Dermatology, No. 1 Hospital of China Medical University, Liaoning, Shenyang, 110001  

2. Department of Dermatology, Fifth Affiliated Hospital of SunYat-sen University, Guangdong, Zhuhai, 519000

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 皮肤病学与性病学
基金 国家自然科学基金 ;  Innovative Research Teams in Universities, Ministry of Education ;  Liaoning Bureau
文献收藏号 CSCD:4808214

参考文献 共 20 共1页

1.  Flint M S. Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge. J Neuroimmunol,2001,113:72-80 CSCD被引 1 次    
2.  Koyama Y. Effect of systemic and topical application of testosterone propionate on the density of epidermal Langerhans cells in the mouse. J Invest Dermatol,1989,92:86-90 CSCD被引 1 次    
3.  Timares L. DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance. Photochem Photobiol,2008,84:422-436 CSCD被引 2 次    
4.  Merad M. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol,2002,3:1135-1141 CSCD被引 6 次    
5.  Ostberg J R. Regulatory potential of fever-range whole body hyperthermia on Langerhans cells and lymphocytes in an antigen-dependent cellular immune response. J Immunol,2001,167:2666-2670 CSCD被引 3 次    
6.  Yoshioka A. Suppression of contact sensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice. Br J Dermatol,1989,120:493-501 CSCD被引 1 次    
7.  Bonneville M. Skin contact irritation conditions the development and severity of allergic contact dermatitis. J Invest Dermatol,2007,127:1430-1435 CSCD被引 3 次    
8.  Huo W. Local hyperthermia at 44 degrees C for the treatment of plantar warts: a randomized, patient-blinded, placebocontrolled trial. J Infect Dis,2010,201:1169-1172 CSCD被引 5 次    
9.  Wang X. Local hyperthermia induces apoptosis of keratinocytes in both normal skin and condyloma acuminata via different pathways. Apoptosis,2009,14:721-728 CSCD被引 3 次    
10.  Cumberbatch M. Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology,2002,105:466-477 CSCD被引 2 次    
11.  Li X. Local hyperthermia could induce migrational maturation of Langerhans cells in condyloma acuminatum. J Dermatol Sci,2009,54:121-123 CSCD被引 3 次    
12.  Saint-Mezard P. Allergic contact dermatitis. Eur J Dermatol,2004,14:284-295 CSCD被引 3 次    
13.  Rowland T L. Differential effect of thalidomide and dexamethasone on the transcription factor NF-kappa B. Int Immunopharmacol,2001,1:49-61 CSCD被引 1 次    
14.  Hildebrandt B. The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol,2002,43:33-56 CSCD被引 76 次    
15.  Igyarto B Z. The evolving function of Langerhans cells in adaptive skin immunity. Immunol Cell Biol,2010,88:361-365 CSCD被引 1 次    
16.  Kimber I. Correlation between lymphocyte proliferative responses and dendritic cell migration in regional lymph nodes following skin painting with contact-sensitizing agents. Int Arch Allergy Appl Immunol,1990,93:47-53 CSCD被引 2 次    
17.  Waithman J. Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J Immunol,2007,179:4535-4541 CSCD被引 2 次    
18.  Larsen C P. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med,1990,172:1483-1493 CSCD被引 2 次    
19.  Shornick L P. Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med,1996,183:1427-1436 CSCD被引 2 次    
20.  Effendy I. Epidermal cytokines in murine cutaneous irritant responses. J Appl Toxicol,2000,20:335-341 CSCD被引 1 次    
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1 Gao Xinghua Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases Frontiers of Medicine,2014,8(1):1-5
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