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Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10

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Guo Rong 1   Huang Kui 2   Jiang Tongzi 1   Li Jian 3   Li Yu 1   Xing Xiaona 1   Cao Yunpeng 1 *  
文摘 Immunotherapy for Alzheimer’s disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid (Aβ) 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 × Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ3-10 is a promising vaccine for AD
来源 Neural Regeneration Research ,2011,6(26):2005-2012 【核心库】
DOI 10.3969/j.issn.1673-5374.2011.26.001
关键词 Alzheimer's disease ; immunotherapy ; gene vaccine ; amyloid plaque ; T cell immunity response ; neural regeneration
地址

1. Department of Neurology, First Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001  

2. Department of Neurology, Shenyang Red Cross Hospital, Liaoning, Shenyang, 110013  

3. Department of Neurology, First Affiliated Hospital of Liaoning Medical College, Liaoning, Jinzhou, 121001

语种 英文
文献类型 研究性论文
ISSN 1673-5374
学科 神经病学与精神病学
基金 国家自然科学基金
文献收藏号 CSCD:4363505

参考文献 共 30 共2页

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引证文献 1 篇

1 Jiang Tongzi Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42) Neural Regeneration Research,2014,9(8):872-877
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