抑郁症患者情绪图片反应特征及杏仁核反应模式的研究
The behavioral response and neural substrate to emotional pictures in patients with major depressive disorder
查看参考文献31篇
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文摘
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目的 探讨抑郁症患者对情感刺激的行为学反应模式及其相关的杏仁核时程反应过程.方法 12例首次发病、未经治疗的抑郁症患者(抑郁症组)和13名健康个体(健康对照组)对观看正性、中性和负性情绪图片的愉悦度等评分;并在被动注视任务下行功能磁共振成像,采用感兴趣区分析方法,比较两组杏仁核在不同情绪图片任务组块间的血氧水平依赖(BOLD)信号时间反应特征.结果 (1)抑郁症组情绪图片愉悦度评分[正性:(6.6 ±0.2)分;中性:(4.7 ±0.1)分]低于健康对照组[分别为(7.7 ±0.2)分和(5.1 ±0.1)分],负性情绪图片评分[(3.4 ±0.3)分]高于健康对照组[(2.2 ±0.2)分;P<0.01].(2)对正性情绪图片任务,两组间右侧杏仁核存在"组×时间"交互作用(P=0.002);抑郁症组杏仁核BOLD信号变化率为(0.02±0.09)%,激活时间后移至Block 2.对负性情绪图片任务,两组间左侧杏仁核有"组×时间"交互作用(P=0.008),右侧杏仁核存在组主效应(P=0.007)和时间主效应(P=0.016),抑郁症组BOLD信号变化率低于(-0.06 ±0.14)%.结论 杏仁核是抑郁症患者丧失愉悦体验和情绪低落的神经基础之一. |
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其他语种文摘
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Objective To explore the behavioral and related amygdaiar temporal response to emotional pictures in individuals with major depressive disorder(MDD).Methods Functional magnetic resonance imaging(fMRI)was adopted to examine the neural substrates of emotional pictures processing in 12 first-episode unmedicated MDD subjects(MDD)and 13 healthy controls(HC).Analyses were focused on the temporal dynamics of the blood-oxygen level dependant(BOLD)signal change in the amygdala across blocks of positive,neutral and negative emotional pictures.The crude score to emotional pictures was also recorded.Results(1)The crude score wag(6.6 ±0.2)to positive pictures and(4.7 ±0.1)to neutral pictures in depressed subjects,lower than that in HC(P＜0.01),and(3.4 ±0.3)to negativc pictures in depressed subjects,which was higher than that in HC(2.2±0.2,P＜0.01).(2)The bilateral amygdala showed attenuated and delayed response to the positive pictures.in which the right amygdala showed"group×time"interaction effect to positive pictures(P=0.002).For the negative pictures,there was"group×time"interaction effect in the left amygdala(P=0.008)and group main effect in the right amygdaia(P=0.007),with the attenuated BOLD signal change in MDD group.Conclusions It suggests that amygdala is one of the key neural substrates to the character of the depressed mood or loss of interest in individuals with MDD.Depressed subiects show the attenuated and blunted behavioral and amygdala response to emotional stimuli,which support the hypothesis of the unspecially blunted emotional response in major depressive disorder. |
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来源
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中华精神科杂志
,2009,42(2):75-80 【核心库】
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关键词
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抑郁症
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磁共振成像
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杏仁核
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习惯化
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国际情绪图片系统
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地址
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同济大学附属同济医院精神医学科, 上海, 200065
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上海交通大学医学院附属精神卫生中心, 上海
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同济大学附属同济医院医学影像科, 上海, 200065
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中国科学院心理研究所, 北京
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Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Floride, 美国
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1006-7884 |
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学科
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神经病学与精神病学 |
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基金
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国家自然科学基金
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国家973计划
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国家留学基金委员会（CSC）项目
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文献收藏号
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CSCD:3648206
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参考文献 共
31
共2页
|
|
1.
Davidson RJ. Anxiety and affective style:role of prefrontal cortex and amygdala.
Biological Psychiatry,2002,51:68-80
|
CSCD被引
16
次
|
|
|
|
|
2.
Drevcts WC. Neuroimaging abnormalities in the amygdala in mood disorders.
Annals of the New York Academy of Sciences,2003,985:420-444
|
CSCD被引
1
次
|
|
|
|
|
3.
Wright P. Neutral faces activate the amygdala during identity matching.
Neumimage,2006,29:628-636
|
CSCD被引
1
次
|
|
|
|
|
4.
Siegle GJ. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression:related and independent features.
Biological Psychiatry,2007,61:198-209
|
CSCD被引
24
次
|
|
|
|
|
5.
Lang PL.
International affective picture system(LAPS):technical manual and affective ratings.Gainesville:NIMH Center for the Study of Emotion and Attention,1997:10-19
|
CSCD被引
1
次
|
|
|
|
|
6.
李清伟. 广泛性焦虑患者视觉任务的功能磁共振成像研究.
中华精神科杂志,2007,40:152-156
|
CSCD被引
3
次
|
|
|
|
|
7.
Cox RW. AFNI:software for analysis and visualization of functional magnetic resonance neuroimages.
COMPUTERS AND BIOMEDICAL RESEARCH,1996,29:162-173
|
CSCD被引
62
次
|
|
|
|
|
8.
Green MJ. The cognitive and neumphysiological basis of emotion dysregulation in bipolar disorder.
Journal of affective disorders,2007,103:29-42
|
CSCD被引
4
次
|
|
|
|
|
9.
Rottenberg J. Vagal withdrawal to a sad film predicts subsequent recovery from depression.
PSYCHOPHYSIOLOGY,2005,42:277-281
|
CSCD被引
1
次
|
|
|
|
|
10.
Bylsma LM. A meta-analysis of emotional reactivity in major depressive disorder.
Clin Psychology Review,2008,28:676-691
|
CSCD被引
12
次
|
|
|
|
|
11.
Gotlib IH. ARentional biases for negative interpersonal stimuli in clinical depression.
Journal of Abnormal Psychology,2004,113:121-135
|
CSCD被引
27
次
|
|
|
|
|
12.
Dunn BD. Categorical and dimensionnl reports of experienced affect to emotion-inducing pictures in depression.
Journal of Abnormal Psychology,2004,113:654-660
|
CSCD被引
1
次
|
|
|
|
|
13.
Siegle GJ. Pupillary and reaction time measures of sustained processing of negative information in depression.
Biological Psychiatry,2001,49:624-636
|
CSCD被引
2
次
|
|
|
|
|
14.
Joormann J. Is this happiness I see:biases in the identification of emotional facial expressions in depression and social phobia.
Journal of Abnormal Psychology,2006,115:705-714
|
CSCD被引
7
次
|
|
|
|
|
15.
Wright CI. A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild AIzheilnor's disease.
Biological Psychiatry,2007,62:1388-1395
|
CSCD被引
6
次
|
|
|
|
|
16.
Phillips ML. Time courfles of left and right amygdalar responses to fearful facial expressions.
Human Brain Mapping,2001,12:193-202
|
CSCD被引
3
次
|
|
|
|
|
17.
Bernhard N. A behavioral and genetic dissection of two forms of olfactory plasticity in Caenorhabditis elegans:adaptation and habituation.
Learning & Memory,2000,7:199-212
|
CSCD被引
1
次
|
|
|
|
|
18.
Epstein J. Lack of ventral striatal response to positive stimuli in depressed vergus normal subjects.
American Journal of Psychiatry,2006,163:1784-1790
|
CSCD被引
10
次
|
|
|
|
|
19.
Shestyuk AY. Reduced sustained brain activity during processing of positive emotional stimuli in major depression.
Biological Psychiatry,2005,57:1089-1096
|
CSCD被引
10
次
|
|
|
|
|
20.
Canli T. Brain activation to emotional words in depressed vs healthy subjects.
NEUROREPORT,2004,15:2585-2588
|
CSCD被引
15
次
|
|
|
|
|
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