Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments
查看参考文献64篇
|
文摘
|
Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect repairs. However, insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic effect. To solve this problem, many studies have been carried out to improve the bioactivity of porous titanium scaffold by surface modifications. In this study, porous Ti6Al4V scaffolds were fabricated using additive manufacturing technique. Porous architectures were built up based on a diamond pore structure unit. Alkali–acid-heat (AH) treatment was applied to create a TiO_2 layer on the porous Ti6Al4V scaffold (AH-porous Ti6Al4V). Subsequently, a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali–acid-heat-treated surface (HT/AH-porous Ti6Al4V). The effects of surface modifications on apatite-forming ability, protein adsorption, cell attachment, cell proliferation and osteogenic gene expression were studied using apatite-forming ability test, protein adsorption assay and in vitro cell culture assay. It was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and vitronectin. In vitro studies indicated that the mesenchymal stem cells (MSCs) cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V. |
|
来源
|
Acta Metallurgica Sinica(English Letters)
,2019,32(9):1075-1088 【核心库】
|
|
DOI
|
10.1007/s40195-019-00920-4
|
|
关键词
|
Additive manufacturing
;
Biomaterials
;
Porous titanium scaffold
;
HA coating
|
|
地址
|
1.
Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001
2.
Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006
3.
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016
|
|
语种
|
英文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1006-7191 |
|
学科
|
金属学与金属工艺 |
|
基金
|
国家973计划
;
国家自然科学基金
;
中国博士后科学基金
;
the Doctor Initial Foundation of Liaoning Province
;
the Affiliated Zhongshan Hospital of Dalian University
|
|
文献收藏号
|
CSCD:6563712
|
参考文献 共
64
共4页
|
|
1.
Wu S.
Mater. Sci. Eng., R,2014,80:1
|
CSCD被引
48
次
|
|
|
|
|
2.
Wang X.
Biomaterials,2016,83:127
|
CSCD被引
132
次
|
|
|
|
|
3.
Mantripragada V P.
J. Biomed. Mater. Res. A,2013,101:3349
|
CSCD被引
7
次
|
|
|
|
|
4.
Chen Q.
Mater. Sci. Eng., R,2015,87:1
|
CSCD被引
123
次
|
|
|
|
|
5.
Zhang B.
Mater. Des,2018,152:30
|
CSCD被引
16
次
|
|
|
|
|
6.
Wauthle R.
Acta Biomater,2015,14:217
|
CSCD被引
41
次
|
|
|
|
|
7.
Geetha M.
Prog. Mater Sci,2009,54:397
|
CSCD被引
317
次
|
|
|
|
|
8.
Ryan G.
Biomaterials,2006,27:2651
|
CSCD被引
77
次
|
|
|
|
|
9.
Jinnapat A.
J. Alloys Compd,2010,499:43
|
CSCD被引
5
次
|
|
|
|
|
10.
Jia J.
J. Mech. Behav. Biomed. Mater,2015,48:229
|
CSCD被引
4
次
|
|
|
|
|
11.
Imwinkelried T.
J. Biomed. Mater. Res. A,2007,81:964
|
CSCD被引
12
次
|
|
|
|
|
12.
Galante J.
J. Biomed. Mater. Res,1973,7:43
|
CSCD被引
2
次
|
|
|
|
|
13.
Li J P.
J. Biomed. Mater. Res. A,2005,73:223
|
CSCD被引
5
次
|
|
|
|
|
14.
Li J P.
Key Eng. Mater,2003,240:547
|
CSCD被引
4
次
|
|
|
|
|
15.
Li Y H.
J. Alloys Compd,2002,345:271
|
CSCD被引
5
次
|
|
|
|
|
16.
Wieding J.
J. Mech. Behav. Biomed. Mater,2014,37:56
|
CSCD被引
13
次
|
|
|
|
|
17.
Bose S.
Prog. Mater Sci,2018,93:45
|
CSCD被引
29
次
|
|
|
|
|
18.
Babaie E.
Sci. Eng,2017,4:1
|
CSCD被引
1
次
|
|
|
|
|
19.
Liu Y. Effect of HIP Treatment on Fatigue Crack Growth Behavior of Ti-6Al-4V Alloy Fabricated by Electron Beam Melting.
Acta Metall. Sin. (Engl. Lett.),2017,30:1163
|
CSCD被引
7
次
|
|
|
|
|
20.
Van Bael S.
Acta Biomater,2012,8:2824
|
CSCD被引
54
次
|
|
|
|
|
了解气象卫星更多信息，请访问