安慰剂效应研究实验设计的历史和发展
The History and Development of Experiment Design for Placebo Effect Studies
查看参考文献53篇
|
文摘
|
安慰剂处理从最初作为研究某种真实治疗效应的控制条件,已演变为研究者直接关注的研究目标,其实验范式也发生了相应变化。双盲随机设计关注真实的治疗是否优于安慰剂处理;欺骗设计直接比较安慰剂处理效应和自然历史效应的差异,关注安慰剂效应本身;公开隐藏设计通过计算公开治疗效应和隐藏治疗效应之差来估计安慰剂效应的大小;平衡范式可同时观察安慰剂效应和真实治疗效应;强化范式通过条件性强化获得加强的安慰剂效应,是研究其作用机制的优化方案;本课题组建立的迁移强化范式,研究安慰剂效应从痛觉到情绪的迁移,是强化范式的重要补充。 |
|
其他语种文摘
|
Placebo treatment initially was a controlled condition in studying certain active therapeutic effect,but now it has been the study object that the investigators who are interested in.And the experimental paradigm also has kept changing accordingly.Randomized and double-blind design concerns about if the active therapy is more effective than placebo treatment;Deceptive design investigates placebo effect itself by directly compared the placebo treatment and natural history condition;Open-hidden paradigm estimates the size of placebo effect by subtracting hidden effect from open effect;Balanced paradigm can observe placebo effect and therapeutic effect simutaneously;Reinforcement paradigm can produce strong placebo effect with conditioned reinforcement and is an optimized paradigm for studying the mechanism of placebo effect;Transferable paradigm built by our team,can observe the transferable effect from pain domain to emotion domain,is a complement to reinforcement paradigm. |
|
来源
|
心理科学进展
,2011,19(8):1115-1125 【核心库】
|
|
关键词
|
安慰剂效应
;
实验范式
;
安慰剂预期分类号B845
;
R395
|
|
地址
|
1.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
2.
河北师范大学教育学院心理系, 石家庄, 050024
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1671-3710 |
|
学科
|
社会科学总论 |
|
基金
|
国家973计划
;
国家863计划
;
国家自然科学基金面上项目
;
中国科学院心理研究所青年人才科研基金
;
中国科学院知识创新工程项目
|
|
文献收藏号
|
CSCD:4318277
|
参考文献 共
53
共3页
|
|
1.
Allan L G. A signal detection theory analysis of the placebo effect.
Evaluation&the Health Professions,2002,25(4):410-420
|
CSCD被引
1
次
|
|
|
|
|
2.
Amanzio M. Neuropharmacological dissection of placebo analgesia:expectation-activated opioid systems versus conditioning-activated specific subsystems.
The Journal of Neuroscience,1999,19(1):484-494
|
CSCD被引
6
次
|
|
|
|
|
3.
Amanzio M. Response variability to analgesics:a role for non-specific activation of endogenous opioids.
Pain,2001,90:205-215
|
CSCD被引
2
次
|
|
|
|
|
4.
Beecher H K. The powerful placebo.
Journal of the American Medical Association,1955,159(17):1602-1606
|
CSCD被引
22
次
|
|
|
|
|
5.
Benedetti F. The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia.
Pain,1996,64(3):535-543
|
CSCD被引
3
次
|
|
|
|
|
6.
Benedetti F. Potentiation of placebo analgesia by proglumide.
The Lancet,1995,346(8984):1231
|
CSCD被引
6
次
|
|
|
|
|
7.
Benedetti F. Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus.
Nature Neuroscience,2004,7(6):587-588
|
CSCD被引
2
次
|
|
|
|
|
8.
Benedetti F. Conscious expectation and unconscious conditioning in analgesic,motor,and hormonal placebo/nocebo responses.
The Journal of Neuroscience,2003,23(10):4315-4323
|
CSCD被引
12
次
|
|
|
|
|
9.
Brody H. Placebos and the Philosophy of Medicine.
Clinical,Conceptual,and Ethical Issues,1980
|
CSCD被引
1
次
|
|
|
|
|
10.
Colloca L. Placebos and painkillers: is mind as real as matter.
Nature Reviews Neuroscience,2005,6(7):545-552
|
CSCD被引
5
次
|
|
|
|
|
11.
Colloca L. How prior experience shapes placebo analgesia.
Pain,2006,124(1/2):126-133
|
CSCD被引
4
次
|
|
|
|
|
12.
Colloca L. Overt versus covert treatment for pain,anxiety,and Parkinson's disease.
The Lancet Neurology,2004,3(11):679-684
|
CSCD被引
3
次
|
|
|
|
|
13.
Davis C E. Regression to the mean or placebo effect-.
The science of the placebo:toward an interdisciplinary research agenda,2002:158-166
|
CSCD被引
1
次
|
|
|
|
|
14.
de Craen A J. Placebos and placebo effects in medicine: historical overview.
Journal of the Royal Society of Medicine,1999,92(10):511-515
|
CSCD被引
5
次
|
|
|
|
|
15.
de la Fuente-Fernández R. Placebo mechanisms and reward circuitry:clues from Parkinson's disease.
Biological Psychiatry,2004,56(2):67-71
|
CSCD被引
1
次
|
|
|
|
|
16.
Fields H L. Placebo analgesia-a role for endorphins.
Trends in Neurosciences,1984,7:271-273
|
CSCD被引
2
次
|
|
|
|
|
17.
Finniss D G. Biological,clinical,and ethical advances of placebo effects.
Lancet,2011,375(9715):686-695
|
CSCD被引
1
次
|
|
|
|
|
18.
Flaten M A. Drug-related information generates placebo and nocebo responses that modify the drug response.
Psychosomatic Medicine,1999,61(2):250-255
|
CSCD被引
1
次
|
|
|
|
|
19.
Guo J Y. Placebo analgesia affects the behavioral despair tests and hormonal secretions in mice.
Psychopharmacology,2011(In press)
|
CSCD被引
1
次
|
|
|
|
|
20.
Hróbjartsson A. Is the placebo powerless-An analysis of clinical trials comparing placebo with no treatment.
The New England journal of medicine,2001,344(21):1594-1602
|
CSCD被引
2
次
|
|
|
|
|
了解气象卫星更多信息，请访问