疼痛恐惧的神经机制及其消退
Neural mechanisms of pain-related fear and its reduction
查看参考文献83篇
|
文摘
|
疼痛恐惧是疼痛基础和临床研究中的一个重要课题。个体对疼痛信息产生过度警觉,诱发不恰当的回避行为,扰乱机体的正常功能,加剧疼痛的现象即为疼痛恐惧。疼痛恐惧可影响个体的疼痛感知以及疼痛相关的注意和回避行为,且在慢性疼痛(如慢性肌骨骼疼痛)的发展、维持个体正常生理功能的丧失中起着重要作用。疼痛恐惧的形成与表达涉及杏仁核、海马、背侧前扣带回皮层、和前额叶皮层等脑区的参与。当前的疼痛恐惧消退的心理-行为干预方法可在疼痛恐惧加工的不同阶段(巩固、再巩固和消退)消退个体的疼痛恐惧。然而,由于恐惧记忆形成过程较为复杂并受多种因素影响,疼痛恐惧记忆消退方法效果较不稳定,其基础研究与临床应用之间仍存在较大的鸿沟。将来研究有必要考虑到疼痛恐惧形成环境的差异以及个体人格特质/心理状态的差异,逐步完善相关消退方法并将其引入临床镇痛,以期帮助患者弱化、擦除甚至改写困扰他们的疼痛恐惧,从而缓解甚至消除病患的疼痛。 |
|
其他语种文摘
|
Pain-related fear is an important topic in both basic and clinical research of pain. It is associated with pain hypervigilance and followed by avoidance behaviors, thereby resulting in the inaccurate processing of non-pain-related information, the disturbance of the body functions, as well as the exacerbation of pain disability. Individual pain-related fear can influence subjective pain perception and pain-related attention bias and avoidance behavior, as well as plays an important role in the development of chronic pain (e.g., chronic musculoskeletal pain) and the maintenance of physiological dysfunctions. Multiple cortical and sub-cortical brain regions, e.g., amygdala, hippocampus, dorsal anterior cingulate cortex, and prefrontal cortex, involve in the formation and expression of pain-related fear. Existing psychological-behavioral intervention therapies of reducing pain-related fear worked in different stages of pain-related fear formation (consolidation, reconsolidation, and extinction). Nevertheless, due to the complexity of pain-related fear formation and the influences of multiple factors, the effect of current psychological intervention therapies for reducing pain-related fear is not stable, yet there is a great gap between the relevant basic research and clinical applications. Differences of contexts in the formation of pain-related fear, as well as individual personality traits and psychological states, should be well taken into consideration in the future study, which will help reduce or even eliminate the disturbing pain-related fear, thus relieving and removing pain sufferings. |
|
来源
|
心理科学进展
,2017,25(10):1758-1768 【核心库】
|
|
DOI
|
10.3724/SP.J.1042.2017.01758
|
|
关键词
|
疼痛恐惧
;
疼痛恐惧的消退
;
疼痛缓解
;
心理-行为方法
|
|
地址
|
1.
西南大学心理学部, 认知与人格教育部重点实验室, 重庆, 400715
2.
遵义师范学院教师教育学院, 遵义, 563002
3.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1671-3710 |
|
学科
|
社会科学总论 |
|
基金
|
国家自然科学基金
;
深圳大学新引进教师科研启动项目
;
重庆市基础与前沿研究计划项目
;
中科院心理所科研启动项目
|
|
文献收藏号
|
CSCD:6081533
|
参考文献 共
83
共5页
|
|
1.
胡理. ICD-11慢性疼痛分类.
中国疼痛医学杂志,2015,21:486-488
|
CSCD被引
1
次
|
|
|
|
|
2.
吕振勇. 疼痛恐惧对疼痛的影响及其认知机制.
心理科学进展,2013,21:817-826
|
CSCD被引
11
次
|
|
|
|
|
3.
杨鸿斌.
天敌气味诱发的先天性恐惧的神经环路基础探究(博士学位论文),2015
|
CSCD被引
1
次
|
|
|
|
|
4.
余莉. 骨科病人术后伤口疼痛的护理.
临床和实验医学杂志,2009,8(7):160
|
CSCD被引
1
次
|
|
|
|
|
5.
袁广琪. 慢性疼痛对老年人的影响研究.
实用医技杂志,2010,17:652-653
|
CSCD被引
2
次
|
|
|
|
|
6.
赵厚德. 实验动物疼痛评价的探讨.
中国比较医学杂志,2004,14(6):385-386
|
CSCD被引
1
次
|
|
|
|
|
7.
Antony J W. Cued memory reactivation during sleep influences skill learning.
Nature Neuroscience,2012,15:1114-1116
|
CSCD被引
4
次
|
|
|
|
|
8.
Asmundson G J G. Is high fear of pain associated with attentional biases for pain-related or general threat? A categorical reanalysis.
The Journal of Pain,2007,8:11-18
|
CSCD被引
6
次
|
|
|
|
|
9.
Auchter A. Reconsolidation-extinction interactions in fear memory attenuation: The role of inter-trial interval variability.
Frontiers in Behavioral Neuroscience,2017,11:2
|
CSCD被引
1
次
|
|
|
|
|
10.
Bendor D. Biasing the content of hippocampal replay during sleep.
Nature Neuroscience,2012,15:1439-1444
|
CSCD被引
5
次
|
|
|
|
|
11.
Blair H T. Synaptic plasticity in the lateral amygdala: A cellular hypothesis of fear conditioning.
Learning & Memory,2001,8:229-242
|
CSCD被引
8
次
|
|
|
|
|
12.
Bukalo O. Prefrontal inputs to the amygdala instruct fear extinction memory formation.
Science Advances,2015,1(6):e1500251
|
CSCD被引
8
次
|
|
|
|
|
13.
Chan W Y M. Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning.
Learning & Memory,2010,17:512-521
|
CSCD被引
4
次
|
|
|
|
|
14.
Choi D S. Sudden amnesia resulting in pain relief: The relationship between memory and pain.
PAIN,2007,132:206-210
|
CSCD被引
5
次
|
|
|
|
|
15.
Costanzi M. Extinction after retrieval: Effects on the associative and nonassociative components of remote contextual fear memory.
Learning & Memory,2011,18:508-518
|
CSCD被引
7
次
|
|
|
|
|
16.
Crombez G. Attention to chronic pain is dependent upon pain-related fear.
Journal of Psychosomatic Research,1999,47:403-410
|
CSCD被引
3
次
|
|
|
|
|
17.
Crombez G. Fear-avoidance model of chronic pain: The next generation.
The Clinical Journal of Pain,2012,28:475-483
|
CSCD被引
6
次
|
|
|
|
|
18.
Crombez G. Attention to pain and fear of pain in patients with chronic pain.
Journal of Behavioral Medicine,2013,36:371-378
|
CSCD被引
9
次
|
|
|
|
|
19.
Dawson A P. Fear of movement, passive coping, manual handling, and severe or radiating pain increase the likelihood of sick leave due to low back pain.
PAIN,2011,152:1517-1524
|
CSCD被引
3
次
|
|
|
|
|
20.
de Carvalho Myskiw J. Behavioral tagging of extinction learning.
Proceedings of the National Academy of Sciences of the United States of America,2013,110:1071-1076
|
CSCD被引
3
次
|
|
|
|
|
了解气象卫星更多信息，请访问