Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry
查看参考文献19篇
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文摘
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Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression. |
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来源
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Neuroscience Bulletin
,2013,29(1):1-2 【核心库】
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DOI
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10.1007/s12264-013-1302-6
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地址
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1.
Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang, 110001
2.
Department of Psychiatry, Yale University School of Medicine, USA, New Haven, 06511
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语种
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英文 |
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ISSN
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1673-7067 |
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学科
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医药、卫生;基础医学 |
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文献收藏号
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CSCD:4784523
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参考文献 共
19
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