Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors
查看参考文献35篇
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文摘
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Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about.the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury |
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来源
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Neural Regeneration Research
,2010,5(17):1303-1307 【核心库】
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DOI
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10.3969/j.issn.1673-5374. 2010.17.004
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关键词
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neural stem cells
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brain-derived neurotrophic factor
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transplantation
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green fluorescent protein
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spinal cord injury
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neural regeneration
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地址
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Department of Orthopedics, First Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1673-5374 |
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学科
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神经病学与精神病学 |
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基金
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辽宁省自然科学基金
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文献收藏号
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CSCD:4041465
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35
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