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Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis

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文摘 Objective:To investigate the protective effects and mechanisms of action of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis (SAP). Methods:The rats were divided into sham-operated, model control, dexamethasone treated, and Salvia miltiorrhiza treated groups. At 3, 6, and 12 h after operation, the mortality rate of different groups, pathological changes, Bcl-2-associated X protein (Bax) and nuclear factor-κB (NF-κB) protein expression levels in multiple organs (the pancreas, liver, kidneys, and lungs), toll-like receptor 4 (TLR-4) protein levels (only in the liver), intercellular adhesion molecule 1 (ICAM-1) protein levels (only in the lung), and terminal deoxynucleotidy transferase mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) staining expression levels, as well as the serum contents of amylase, glutamate-pyruvate transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), blood urea nitrogen (BUN), and creatinine (CREA) were observed. Results:The mortality rate of the dexamethasone treated group was significantly lower than that of the model control group (P<0.05). The pathological changes in multiple organs in the two treated groups were relieved to different degrees (P<0.05 and P<0.01, respectively), the expression levels of Bax and NF-κB proteins, and apoptotic indexes of multiple organs were reduced (P<0.05 and P<0.01, respectively). The contents of amylase, GPT, GOT, BUN, and CREA in the two treated groups were significantly lower than those in model control groups (P<0.05 and P<0.01, respectively). The expression level of ICAM-1 protein in the lungs (at 3 and 12 h) in the dexamethasone treated group was significantly lower than that in the Salvia miltiorrhiza treated group (P<0.05). The serum contents of CREA (at 12 h) and BUN (at 6 h) of the Salvia miltiorrhiza treated group were significantly lower than those in the dexamethasone treated group (P<0.05). Conclusions:Both dexamethasone and Salvia miltiorrhiza can reduce the inflammatory reaction, regulate apoptosis, and thus protect multiple organs of rats with SAP.
来源 Journal of Zhejiang University. Science B , Biomedicine & Biotechnology,2012,13(11):919-931 【核心库】
DOI 10.1631/jzus.b1100351
关键词 Dexamethasone ; Salvia miltiorrhiza ; Pancreatitis ; Multiple organs ; Rats ; Apoptosis ; NF-κB ; TLR-4 ; ICAM-1 ; Tissue microarrays
地址

1. Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092  

2. Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, 310022  

3. Department of Orthopaedics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, 314001  

4. Zhejiang Chinese Medical University, Hangzhou, 310053

语种 英文
ISSN 1673-1581
学科 内科学
基金 by the Foundation for the Excellent Middle-Aged and Talented Young Persons of Zhejiang Province“151”, China
文献收藏号 CSCD:4674772

参考文献 共 37 共2页

1.  Campo G M. Chondroitin-4-sulphate reduced oxidative injury in caerulein-inducedpancreatitis in mice: the involvement of NF-kappaBtranslocation and apoptosis activation. Exp. Biol. Med.(Maywood),2008,233(6):741-752 CSCD被引 3    
2.  Cui Y. Separation of water-soluble active components in Salviamiltiorrhiza bge. f. alba using capillary zone electrophoresis. Se Pu, (in Chinese),2007,25(5):686-689 CSCD被引 2    
3.  Ding M. Study on the mechanisms of anextract of Salvia miltiorrhiza on the regulation of permeabilityof endothelial cells exposed to tumor necrosisfactor-α. J. Pharm. Pharmacol.,2007,59(7):1027-1033 CSCD被引 5    
4.  Foitzik T. Endothelin receptor blockade in severeacute pancreatitis leads to systemic enhancement of capillarypermeability and improved survival rates. Surgery,2000,128(3):399-407 CSCD被引 16    
5.  Gomez G. Acute pancreatitis signals activationof apoptosis-associated and survival genes in mice. Exp. Biol. Med. (Maywood),2001,226(7):692-700 CSCD被引 7    
6.  Kandil E. Dexamethasone mediates protectionagainst acute pancreatitis via up-regulation ofpancreatitis-associated proteins. World J. Gastroenterol.,2006,12(42):6806-6811 CSCD被引 2    
7.  Kim J S. Salvia miltiorrhizawater-soluble extract, but not its constituent salvianolicacid B, abrogates LPS-induced NF-kappaB signaling inintestinal epithelial cells. Clin. Exp. Immunol.,2005,141(2):288-297 CSCD被引 7    
8.  Lam F F. Relaxant effects ofSalvia miltiorrhiza aqueous extract and its constituentdanshensu on rat coronary artery are mediated by inhibitionof calcium channels. Vascul. Pharmacol.,2007,46(4):271-277 CSCD被引 14    
9.  Li D. Inhibitory effects ofSalvia miltiorrhiza injection coordinated with dexamethasoneon interleukin-13 and eotaxin expression inlung of asthmatic rats. Chin. J. Int. Trad. West. Med. (in Chinese),2006,26(11):1007-1110 CSCD被引 1    
10.  Martin Alonso M A. Cytokinesand other immunological parameters as markers ofdistant organ involvement in acute pancreatitis. Med. Clin.(Barc.),2007,128(11):401-406 CSCD被引 1    
11.  Meng Y. Effect of resveratrolon activation of nuclear factor kappa-B and inflammatoryfactors in rat model of acute pancreatitis. World J. Gastroenterol.,2005,11(4):525-528 CSCD被引 12    
12.  Mizuguchi T. Successful management of severe acute pancreatitis withmultiple organ failure. Pancreas,2004,28(2):211-213 CSCD被引 1    
13.  Muller C A. Dexamethasone affects inflammationbut not trypsinogen activation in experimental acute pancreatitis. Eur. Surg. Res.,2008,40(4):317-324 CSCD被引 1    
14.  Qu J G. Effect of urinastatinon microcirculation of extrapancreatic organs in rats withacute necrotizing pancreatitis. Chin. J. Bases Clin. GeneralSurg. (in Chinese),2003,10(3):234-235 CSCD被引 1    
15.  Samuilov V D. Programmedcell death. Biochemistry (Mosc.),2000,65(8):873-887 CSCD被引 1    
16.  Sha H. Resveratrol ameliorates hepatic injuryvia the mitochondrial pathway in rats with severe acutepancreatitis. Eur. J. Pharmacol.,2008,601(1/3):136-142 CSCD被引 1    
17.  Song J M. Extracellular heat-shock protein 70 aggravatescerulein-induced pancreatitis through toll-like receptor-4in mice. Chin. Med. J. (Engl.),2008,121(15):1420-1425 CSCD被引 8    
18.  Strate T. Systemic intravenous infusion of bovine hemoglobinsignificantly reduces microcirculatory dysfunctionin experimentally induced pancreatitis in the rat. Ann. Surg.,2003,238(5):765-771 CSCD被引 5    
19.  Sugiyama Y. Different effects of dexamethasone and the nitricoxide synthase inhibitor L-NAME on caerulein-inducedrat acute pancreatitis, depending on the severity. Inflammopharmacology,2005,13(1/3):291-301 CSCD被引 1    
20.  Takeyama Y. Significance of apoptotic cell death insystemic complications with severe acute pancreatitis. J.Gastroenterol.,2005,40(1):1-10 CSCD被引 19    
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