大鼠神经性勃起功能障碍模型在实验中的应用
Application of Rat Model of Neurotic Erectile Dysfunction in Experiment
查看参考文献28篇
|
文摘
|
勃起功能障碍(ED)是指阴茎持续不能达到和/或维持足够的勃起以获得满意的性生活。ED对于患者及其性伴侣的生活质量会带来较大的影响。近些年来,为阐明ED的病理生理机制,多种ED动物模型应运而生,并取得了一系列的进展。啮齿类动物的海绵体神经(CN)在解剖上与人类相近,且具有性价比高、粗大易辨认等优势,逐渐成为ED动物模型的主流。本文回顾了近年来大鼠双侧CN损伤所致神经性ED动物模型的建立方式,总结了其模型的检测及评价指标,探讨了ED动物模型在基础实验研究当中的应用及进展。 |
|
其他语种文摘
|
Erectile dysfunction(ED)refers to the persistent inability to achieve and/ or maintain a sufficient erection of the penis to obtain a satisfactory sexual life, which affects the quality of life of the patients and their sexual partners. To decipher the pathophysiological mechanism of ED, researchers have established a variety of animal models and achieved a series of progress. The cavernous nerve(CN)of rodents, anatomically similar to that of humans, is cost-effective, thick, and easy to be identified, which has gradually become the mainstream of animal models. In this paper, we reviewed the modeling methods of the neurological ED caused by bilateral CN injury in rats in recent years, summarized the model evaluation indicators, and discussed the application and progress of ED models in basic experimental research. |
|
来源
|
中国医学科学院学报
,2023,45(2):311-316 【核心库】
|
|
DOI
|
10.3881/j.issn.1000-503X.14954
|
|
关键词
|
海绵体神经损伤
;
勃起功能障碍
;
大鼠
;
动物模型
|
|
地址
|
1.
浙江中医药大学第二临床医学院, 杭州, 310053
2.
浙江省人民医院杭州医学院附属人民医院泌尿外科, 杭州, 310014
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1000-503X |
|
学科
|
基础医学 |
|
基金
|
浙江省卫生健康科技计划项目
|
|
文献收藏号
|
CSCD:7470010
|
参考文献 共
28
共2页
|
|
1.
Irwin G M. Erectile dysfunction.
Prim Care,2019,46(2):249-255
|
CSCD被引
7
次
|
|
|
|
|
2.
Glina S. Diagnosis of erectile dysfunction.
Curr Opin Psychiatry,2014,27(6):394-399
|
CSCD被引
3
次
|
|
|
|
|
3.
Wu Y N. Spontaneous regeneration of nerve fiber and irreversibility of corporal smooth muscle fibrosis after cavernous nerve crush injury: evidence from serial transmission electron microscopy and intracavernous pressure.
Urology,2018,118:98-106
|
CSCD被引
3
次
|
|
|
|
|
4.
Haglind E. LAPPRO steering committee. Urinary incontinence and erectile dysfunction after robotic versus open radical prostatectomy: a prospective, controlled, nonrandomised trial.
Eur Urol,2015,68(2):216-225
|
CSCD被引
14
次
|
|
|
|
|
5.
Chen Z. Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury.
Theranostics,2019,9(22):6354-6368
|
CSCD被引
9
次
|
|
|
|
|
6.
Matsui H. Increased level of tumor necrosis factor-alpha (TNF-α) leads to downregulation of nitrergic neurons following bilateral cavernous nerve injury and modulates penile smooth tone.
J Sex Med,2021,18(7):1181-1190
|
CSCD被引
1
次
|
|
|
|
|
7.
Li H. The effect of cavernous nerve traction on erectile function in rats.
PLoS One,2017,12(10):e0186077
|
CSCD被引
2
次
|
|
|
|
|
8.
Sezen S F. Immunophilin ligand FK506 is neuroprotective for penile innervation.
Nat Med,2001,7(10):1073-1074
|
CSCD被引
5
次
|
|
|
|
|
9.
Cong R. Comprehensive analysis of lncRNA expression pattern and lncRNA-miRNA-mRNA network in a rat model with cavernous nerve injury erectile dysfunction.
J Sex Med,2020,17(9):1603-1617
|
CSCD被引
1
次
|
|
|
|
|
10.
Chalasani V. Contemporary results of focal therapy for prostate cancer using cryotherapy.
Panminerva Med,2010,52(3):217-222
|
CSCD被引
1
次
|
|
|
|
|
11.
Yang R. Adipose-derived stem cells ameliorate erectile dysfunction after cavernous nerve cryoinjury.
Andrology,2015,3(4):694-701
|
CSCD被引
6
次
|
|
|
|
|
12.
Cho M C. Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats.
J Sex Med,2011,8(3):712-721
|
CSCD被引
9
次
|
|
|
|
|
13.
Ying C. Erectile function restoration after repair of resected cavernous nerves by adipose-derived stem cells combined with autologous vein graft in rats.
Cell Mol Neurobiol,2014,34(3):393-402
|
CSCD被引
4
次
|
|
|
|
|
14.
Li M. Comparative study of intracavernous pressure and cavernous pathology after bilateral cavernous nerve crushing and resection in rats.
Asian J Androl,2020,22(6):629-635
|
CSCD被引
3
次
|
|
|
|
|
15.
Lewis J E. Blood pressure within the corpus cavernosum penis of the bull.
J Reprod Fertil,1968,17(1):155-156
|
CSCD被引
4
次
|
|
|
|
|
16.
Lee J. Combination therapy with a JNK inhibitor and hepatocyte growth factor for restoration of erectile function in a rat model of cavernosal nerve injury: comparison with a JNK inhibitor alone or hepatocyte growth factor alone.
Int J Mol Sci,2021,22(23):12698
|
CSCD被引
2
次
|
|
|
|
|
17.
Gu S J. A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury.
Andrology,2021,9(6):1893-1901
|
CSCD被引
3
次
|
|
|
|
|
18.
Wu C J. Vacuum therapy ameliorates erectile dysfunction in bilateral cavernous nerve crush rats by inhibiting apoptosis and activating autophagy.
Asian J Androl,2021,23(3):273-280
|
CSCD被引
2
次
|
|
|
|
|
19.
Ouyang X. MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury.
Stem Cell Res Ther,2018,9(1):246
|
CSCD被引
11
次
|
|
|
|
|
20.
Wang Y. Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury.
Asian J Androl,2019,21(5):452-459
|
CSCD被引
3
次
|
|
|
|
|
了解气象卫星更多信息，请访问