不同药物联合对男性高血压患者勃起功能的影响
Effect of Combined Antihypertensive Therapy on the Erectile Function in Male Hypertensives

刘培君 ¹ 余静 ¹ ^* 康秀峰 ² 徐电 ¹ 郭雪娅 ¹ 李秀丽 ¹ 赵锋 ¹ 常鹏 ¹ 甄玲玲 ¹ 白锋 ¹

文摘	目的探讨不同联合降压方案对高血压男性患者勃起功能的影响.方法采用前瞻性随机,平行,对照,固定治疗方案将148名≤60岁男性高血压患者随机分为3组:A组[非洛地平5 mg/d+厄贝沙坦150 mg/d(n=49)],B组[非洛地平5 mg/d+琥珀酸美托洛尔47.5 mg/d(n=46)],C组[非洛地平5 mg/d+氢氯噻嗪12.5 mg/d(n=53)].治疗4周若血压≥140/90 mm Hg,非洛地平剂量加倍.随访6月.采用国际男性性功能判断指标(IIEF-5)分别于治疗前,后对IIEF-5和血清睾酮,性激素结合球蛋白(SHBG)进行评定.结果治疗后3组降压达标率,有效率组间比较均无统计学差异(均P>0.05).治疗前,后勃起功能障碍(ED)的总发生率分别为34.46%,35.81%,差异无统计学意义(P>0.05).3组治疗前后轻,中,重度ED的发生率之间亦无统计学差异.3组治疗前后中,重度ED的IIEF-5评分比较无统计学差异,但A组可提高轻,中度ED患者的IIEF-5评分.3组血清睾酮和SHBG治疗前后比较无统计学差异.结论非洛地平缓释片联合厄贝沙坦片有利于男性高血压轻,中度ED患者性功能的改善
其他语种文摘	Objective This study was to assess the effect of different combination antihypertensive therapy on erectile dysfunction(ED) in male hypertensives. Methods A total of 148 male hypertensives aged ≤60 years were enrolled in this prospective randomized controled interventional study, and followed up for 6 months. Patients were divided into 3 groups including Felodipine(5 mg/d)+Irbesartan(150 mg/d)(A,n=49), Felodipine(5 mg/d)+Metoprolol(47.5 mg/d)(B,n=46) and Felodipine(5 mg/d)+Hydrochlorothiazide(12.5 mg/d)(C,n=53) respectively. Doses of Felodipine were doubled after 4 weeks if blood pressure was ≥140/90 mm Hg. Erectile function was assessed according to the 5-Item version of the international index of erectile dysfunction(IIEF-5) questionnaire. Blood samples were taken for assessing the testosterone(T) and the sex hormone binding globulin(SHBG). Results There were a significant blood pressure decrease in all 3 groups(P<0.01) and no difference(P>0.05) among these 3 groups. There was no statistically significant difference of total prevalence of ED between before and after treatment, with prevalence rate of 34.46% and 35.81%.An improvement of sexual function was noted in the patients with mild to moderate sexual dysfunction in group A. There was no significant difference of sexual function between group A and B. There were some changes of the testosterone and SHBG between groups before and after treatment in 6 months follow up(P>0.05). Conclusion Combination therapy is effective to lowing blood pressure of hypertensive. Combination of treatment of Felodipine +Irbesartan seems be better to prevent the ED in male hypertensives with mild to moderate sexual dysfuntion
来源	中华高血压杂志 ,2010,18(4):365-369 【扩展库】
关键词	高血压 ; 勃起功能 ; 非洛地平 ; 厄贝沙坦 ; 琥珀酸美托洛尔 ; 氢氯噻嗪
地址	1. 兰州大学第二医院心血管内科, 甘肃, 兰州, 730030 2. 69210部队医院内科, 新疆, 喀什, 844700
语种	中文
文献类型	研究性论文
ISSN	1673-7245
学科	临床医学
基金	甘肃省技术研究与开发专项计划
文献收藏号	CSCD:4008207