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生理毒代动力学模型及其在有机污染物水生生态毒理研究中的应用
Physiologically Based Toxicokinetic Models and Application in Aquatic Ecotoxicological Studies of Organic Pollutants: A Review

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吕银知 1,2   张芊芊 3   赵建亮 3 *   姚理 1,2   应光国 3  
文摘 人类生产和生活使用各种人工合成的化学品,种类和数量急剧增长,对生态系统和人体健康造成了极大威胁。因此,亟需采用高效的方法对数量巨大的化合物进行毒性评价。对生理毒代动力学(PBTK)模型的建立过程及其在污染物生态毒理研究中的应用进行了综述。PBTK模型,又称生理药代动力学(PBPK)模型,是利用生理学和解剖学等原理,将生物体简化为用血流连接的肝、肾和脂肪等各组织器官房室,模拟化合物在生物体内的吸收、分布、代谢和排泄过程。模型参数包括生理参数和生化参数2个部分,可用MATLAB等软件进行模拟。模型已应用于数百余种有机污染物在鱼体等水生生物体的毒代动力学模拟。已有模拟结果能够预测化合物在生物体内的有效剂量,对化合物毒性进行评估,并可用于不同物种、不同剂量和不同暴露途径间的外推,有力推进了污染物生态毒理研究工作的开展。
其他语种文摘 Many varieties of synthetic chemicals are used in our daily life and production activities. Synthetic chemicals are increasing rapidly in terms of class,number and amount. This could pose serious threats to the ecosystem and human health. Hence,it is urgent to develop an efficient evaluation approach to assess the toxicity for these chemicals,instead of using traditional toxicity test methods. In this context,we reviewed physiologically based toxicokinetic (PBTK) model and its application in aquatic ecotoxicological studies for organic chemicals. PBTK model, also known as physiologically based pharmacokinetic (PBPK) model,has gradually become a powerful tool for ecotoxicological study. Based on the knowledge of physiology and anatomy,the organisms are simplified as several compartments to represent various tissues and organs,which are connected with each other via blood flow; so that the absorption,distribution,metabolism and excretion (ADME) processes of compounds in organisms can be simulated using the PBTK model. The parameters in the PBTK model normally include physiological parameters and biochemical parameters,which can be applied in the simulation using MATLAB or other software. So far, the PBTK model has been widely applied to the simulation of several hundreds of organic chemicals in fish species and some other aquatic organisms. In literature,several hundreds of organic chemicals in fish have been simulated by the PBTK model. The modeling results displayed good prediction of the effective dose for organic pollutants in organisms,which is then applied to evaluate the toxicity effects of the compounds. The PBTK model can also be used for the extrapolations among different species,different doses and different exposure pathways. As a result,the application of PBTK model promoted and enhanced the research on the ecotoxicology of organic chemicals.
来源 生态毒理学报 ,2018,13(5):11-26 【核心库】
DOI 10.7524/AJE.1673-5897.20171103001
关键词 有机污染物 ; 水生生物 ; 生理毒代动力学模型 ; 生态毒理 ;
地址

1. 中国科学院广州地球化学研究所, 有机地球化学国家重点实验室, 广州, 510640  

2. 中国科学院大学, 北京, 100049  

3. 华南师范大学环境研究院, 广州, 510006

语种 中文
文献类型 综述型
ISSN 1673-5897
学科 环境科学基础理论
基金 国家自然科学基金项目 ;  广东省科技计划项目
文献收藏号 CSCD:6374878

参考文献 共 65 共4页

1.  王中钰. 面向化学品风险评价的计算(预测)毒理学. 中国科学:化学,2016,46(2):222-240 被引 20    
2.  European Chemicals Agency (ECHA). List of Pre-registered Substances,2017 被引 1    
3.  王艺璇. 有机磷酸酯在水环境中的残留及生态风险评价. 环境与健康杂志,2015,32(10):935-939 被引 4    
4.  张璐璐. 中国典型城市水环境中邻苯二甲酸酯类污染水平与生态风险评价. 生态毒理学报,2016,11(2):421-435 被引 17    
5.  Raevsky O A. Classification and quantification of the toxicity of chemicals to guppy,fathead minnow,and rainbow trout. Part 2. Polar narcosis mode of action. Molecular Informatics,2009,28(2):163-174 被引 1    
6.  Arnot J A. Policies for chemical hazard and risk priority setting: Can persistence,bioaccumulation, toxicity,and quantity information be combined?. Environmental Science and Technology,2008,42(13):4648-4654 被引 4    
7.  Sijm D T H M. Internal Effect Concentration: Link between Bioaccumulation and Ecotoxicity for Organic Chemicals. The Handbook of Environmental Chemistry: Bioaccumulation-New Aspects and Developments. 2,2000:167-199 被引 1    
8.  Brox S. A quantitative HPLC-MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos. Analytical and Bioanalytical Chemistry,2014,406(20):4831-4840 被引 3    
9.  Vogs C. A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus. Environmental Toxicology and Chemistry,2015,34(1):100-111 被引 2    
10.  Bernillon P. Statistical issues in toxicokinetic modeling: A Bayesian perspective. Environmental Health Perspectives,2000,108:883-893 被引 1    
11.  刘佳. 沉积物中2,2',4,4'-四溴联苯醚(BDE-47)在铜锈环棱螺体内的毒代动力学及其繁殖毒性. 生态毒理学报,2012,7(3):259-267 被引 9    
12.  Edginton A N. Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development. Expert Opinion on Drug Metabolism and Toxicology,2008,4(9):1143-1152 被引 5    
13.  Chiu W A. Evaluation of physiologically based pharmacokinetic models for use in risk assessment. Journal of Applied Toxicology,2007,27(3):218-237 被引 3    
14.  Wi'sniowska B. Humans vary,so cardiac models should account for that too!. Frontiers in Physiology,2017,8:1-9 被引 1    
15.  Clewell R A. Development and specification of physiologically based pharmacokinetic models for use in risk assessment. Regulatory Toxicology and Pharmacology,2008,50(1):129-143 被引 3    
16.  Hamelin G. Physiologically based modeling of p-tert-octylphenol kinetics following intravenous,oral or subcutaneous exposure in male and female Sprague-Dawley rats. Journal of Applied Toxicology,2010,30(5):437-449 被引 1    
17.  Ling J. Interspecies scaling of therapeutic monoclonal antibodies: Initial look. The Journal of Clinical Pharmacology,2009,49(12):1382-1402 被引 3    
18.  Andersen M E. Toxicokinetic modeling and its applications in chemical risk assessment. Toxicology Letters,2003,138:9-27 被引 8    
19.  Gerlowski L E. Physiologically based pharmacokinetic modeling: Principles and applications. Journal of Pharmaceutical Sciences,1983,72(10):1103-1127 被引 1    
20.  Himmelstein K J. A review of the applications of physiologically based pharmacokinetic modeling. Journal of Pharmacokinetics and Biopharmaceutics,1979,7(2):127-145 被引 1    
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