帮助 关于我们

返回检索结果

Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children

查看参考文献33篇

文摘 Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. Methods A total of 171 S. pneumoniae strains were isolated from 11 medical centers in China from 2006 to 2008. All the isolates were characterized via serotyping and antibiotic susceptibility determination. The erythromycin-resistant isolates were further characterized via ermB and mefA gene detection, multi-locus sequence typing analysis, and pulsed-field gel electrophoresis. Results A total of 164 (95.9%) isolates showed resistance to erythromycin, of which 162 strains with high high-level resistance (MIC ≥ 256 μg/ml). A total of 104 (63.4%) isolates carry the ermB gene alone, whereas 59 (36.0%) harbor both ermB and mefA genes. Of the 59 strains, 54 were of serotypes 19A and 19F and were identified as highly clonal and related to the Taiwan~(19F)-14 clone. Conclusions The erythromycin resistance rate in IPD isolates is significantly high and is predominantly mediated by the ermB gene. Isolates that carry both ermB and mefA genes are predominantly of serotypes 19A and 19F.
来源 Chinese Medical Journal ,2013,126(8):1522-1527 【核心库】
DOI 10.3760/cma.j.issn.0366-6999.20122185
关键词 Streptococcus pneumonia ; invasive pneumococcal diseases ; erythromycin ; resistance ; genes
地址

1. Beijing Pediatrics Research Institute, Beijing Children’s Hospital, (Capital Medical University), Key Laboratory of Major Diseases in Children and the National Key Discipline of Pediatrics, Ministry of Education, Beijing, 100045  

2. Lanzhou Institute of Biological Products, Gansu, Lanzhou, 730030  

3. Shenzhen Children’s Hospital, Guangdong, Shenzhen, 518000  

4. Pediatric Hospital of Fudan University, Shanghai, 200102  

5. Shengjing Hospital Affiliated to China Medical University, Liaoning, Shenyang, 110100  

6. Nanjing Children’s Hospital, Jiangsu, Nanjing, 210000  

7. Tianjin Children’s Hospital, Tianjin, 300000  

8. Chongqing Children’s Hospital Affiliated to Chongqing Medical University, Chongqing, 401000  

9. Yuying Children’s Hospital Affiliated to Wenzhou Medical College, Zhejiang, Wenzhou, 325500  

10. Soochow University Pediatric Hospital, Jiangsu, Suzhou, 215400  

11. Anhui Medical University Affiliated Hospital, Anhui, Hefei, 230100  

12. First Affiliated Hospital of Xinjiang Medical University, Xinjiang, Urumqi, 830000

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 儿科学
基金 supported by the grants from Beijing Nova Program ;  the Special Fund for High-level Personnel Development in the Beijing Health System ;  the Beijing Guidance Teacher Technology Item of Excellent Doctorship Thesis
文献收藏号 CSCD:4808208

参考文献 共 33 共2页

1.  World Health Organization. Pneumococcal conjugated vaccine for childhood immunization-WHO position paper. Wkly Epidemiol Rec,2007,82:93-104 CSCD被引 20 次    
2.  Lee N Y. Carriage of antibiotic-resistant pneumococci among Asian children: a multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Clin Infect Dis,2001,32:1463-1469 CSCD被引 18 次    
3.  Song J H. Spread of drug-resistant Streptococcus pneumoniae in Asian chontries. Clin Infect Dis,1999,28:1206-1211 CSCD被引 24 次    
4.  Kim S H. Changing trend of antimicrobial resistance and serotypes in Streptococcus pneumoniae in Asian countries: an ANSORP study. Antimicrob Agents Chemother. Antimicrob Agents Chemother,2012,56:1418-1426 CSCD被引 48 次    
5.  Yao K H. Streptococcus pneumoniae diseases in Chinese children: past, present and future. Vaccine,2008,26:4425-4433 CSCD被引 53 次    
6.  Xue L. Serotype distribution and antimicrobial resistant of Strepotococcus pneumoniae isolates that cause invasive disease among Chinese children. Clin Infect Dis,2010,50:741-744 CSCD被引 20 次    
7.  Qian J. Diversity of pneumococcal surface protein A (PspA) and relation to sequence typing in Streptococcus pneumoniae causing invasive disease in Chinese children. Eur J Clin Microbiol Infect Dis,2011,4:1296-1299 CSCD被引 1 次    
8.  Kelly L M. Comparison of agar dilution, microdilution, E-test, and disk diffusion methods for testing activity of cefditoren against Streptococcus pneumoniae. J Clin Microbiol,1999,37:3296-3299 CSCD被引 4 次    
9.  Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing; 20th informational supplement,2010:M100-S20 CSCD被引 2 次    
10.  Sutcliffe J. Detection of erythromycin-resistant determinants by PCR. Antimicrob Agents Chemother,1996,40:5262-5266 CSCD被引 46 次    
11.  Lefevre J C. DNA fingerprinting of Streptococcus pneumoniae strains by pulsed-field gel electrophoresis. J Clin Microbiol,1993,31:2724-2728 CSCD被引 3 次    
12.  Enright M C. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology,1998,144:3049-3060 CSCD被引 16 次    
13.  Kilgore P E. Epidemiology of childhood pneumococcal meningitis in China, South Korea and Vietnam, 1999 through 2003: implications for estimating the burden of disease and prevention through immunization. Presented at: 43rd Annual Meeting of the Infectious Diseases Society of America,2005:142 CSCD被引 1 次    
14.  Cho H J. Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold. Soc Sci Med,2004,58:623-629 CSCD被引 1 次    
15.  Bharathiraja R. Factors affecting antibiotic prescribing pattern in pediatric practice. Indian J Pediatr,2005,72:877-879 CSCD被引 1 次    
16.  Osatakul S. Appropriate use of empirical antibiotics in acute diarrhoea: a cross-sectional survey in southern Thailand. Ann Trop Paediatr,2007,27:115-122 CSCD被引 1 次    
17.  Ho P L. Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance. Eur J Clin Microbiol Infect Dis,2006,25:323-327 CSCD被引 2 次    
18.  Liu Y. Serotype distribution and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from children in China younger than 5 years. Diagn Microbiol Infect Dis,2008,61:256-263 CSCD被引 22 次    
19.  Lonks J R. Implication of antimicrobial resistance in the empirical treatment of community-acquired respiratory infections: the case of macrolide. J Antimicrob Chemother,2002,50(suppl S2):87-91 CSCD被引 1 次    
20.  Musher D M. Emergence of macrolide resistance during treatment of pneumococcal pneumonia. N Engl J Med,2002,346:630-631 CSCD被引 1 次    
引证文献 1 篇

1 吕雪艳 反复冻融对23价肺炎球菌荚膜多糖稳定性的影响 中国新药杂志,2020,29(21):2515-2520
CSCD被引 0 次

显示所有1篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护：中国科学院文献情报中心
地址：北京中关村北四环西路33号 邮政编码：100190 联系电话：(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号