缰核在抑郁症中的作用:研究和治疗的新途径
Habenula: New Approach to Study and Treatment of Depression
查看参考文献39篇
|
文摘
|
缰核是哺乳动物神经系统中连接前脑和中脑的重要节点,这一古老的核团因其与抑郁症的密切联系,近来获得国内外研究者的关注。缰核接受来自边缘系统、基底神经节等的传入信号,向下投射到中脑5-羟色胺系统和多巴胺系统。在应激条件下缰核免疫活动增强,向下游的投射信号增强,以此调节单胺类递质释放,参与抑郁症的发病机制,并且参与抗抑郁治疗的起效途径。这些证据提示缰核在抑郁症中具有重要作用,将成为研究和治疗的新途径。未来研究应从缰核与上下游核团的神经联系、与丘脑-垂体-肾上腺轴的相互影响、以及与免疫激活的交互作用等方面进一步探索,为研究抑郁症病理机制和治疗方法提供线索。 |
|
其他语种文摘
|
The habenula is an important connecting node between forebrain and midbrain in mammals. This evolutionarily old brain structure is getting increased attention for its role in depression. This review describes the neuroanatomy of the habenular complex, and discusses its involvement in stress induced behavioral responses. A growing body of animal and clinical researche has focused on the influence of habenula on the monoamine systems. Recent discoveries indicate that habenula activation plays a prominent role in inhibiting serotonergic and dopaminergic neurons, which possibly leads to the depressive-like behaviors in animals under stress. They provide new insights into the study and treatment of depression. The interactions between habenular dysfunction and the HPA axis as well as the neuroimmune system in general worths further investigations in the future. |
|
来源
|
心理科学进展
,2013,21(7):1213-1219 【核心库】
|
|
关键词
|
缰核
;
抑郁症
;
应激
;
5-HT
;
多巴胺
|
|
地址
|
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1671-3710 |
|
学科
|
社会科学总论 |
|
基金
|
国家自然科学基金项目
;
中国科学院知识创新工程项目
|
|
文献收藏号
|
CSCD:4908082
|
参考文献 共
39
共2页
|
|
1.
Benabid A L. Deep brain stimulation for parkinson's disease.
Current Opinion in Neurobiology,2003,13:696-706
|
CSCD被引
17
次
|
|
|
|
|
2.
Bjartmar L. Long-term treatment with antidepressants, but not environmental stimulation, induces expression of np2 mrna in hippocampus and medial habenula.
Brain Research,2010,1328:25-33
|
CSCD被引
2
次
|
|
|
|
|
3.
Cirulli F. Increased number of mast cells in the central nervous system of adult male mice following chronic subordination stress.
Brain, Behavior, and Immunity,1998,12:123-133
|
CSCD被引
2
次
|
|
|
|
|
4.
Hauptman J S. Potential surgical targets for deep brain stimulation in treatment-resistant depression.
Neurosurgical Focus,2008,25:E3
|
CSCD被引
2
次
|
|
|
|
|
5.
Heldt S A. Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion.
Brain Research,2006,1073/1074:229-239
|
CSCD被引
2
次
|
|
|
|
|
6.
Hikosaka O. The habenula: From stress evasion to value-based decision-making.
Nature Reviews Neuroscience,2010,11:503-513
|
CSCD被引
16
次
|
|
|
|
|
7.
Hikosaka O. Habenula: Crossroad between the basal ganglia and the limbic system.
Journal of Neuroscience,2008,28:11825-11829
|
CSCD被引
10
次
|
|
|
|
|
8.
Hirschfeld R M. History and evolution of the monoamine hypothesis of depression.
Journal of Clinical Psychiatry,2000,61:4-6
|
CSCD被引
10
次
|
|
|
|
|
9.
Jhou T C. The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta.
The Journal of Comparative Neurology,2009,513:566-596
|
CSCD被引
8
次
|
|
|
|
|
10.
Ji H. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA_A receptor-mediated mechanism.
The Journal of Neuroscience,2007,27:6923-6930
|
CSCD被引
10
次
|
|
|
|
|
11.
Klemm W R. Habenular and interpeduncularis nuclei: Shared components in multiple-function networks.
Medical Science Monitor,2004,10:RA261-RA273
|
CSCD被引
1
次
|
|
|
|
|
12.
Lecourtier L. A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition.
Neuroscience & Biobehavioral Reviews,2007,31:658-672
|
CSCD被引
7
次
|
|
|
|
|
13.
Lee Y A. Neurodevelopmental disruption of cortico-striatal function caused by degeneration of habenula neurons.
Plos One,2011,6:e19450
|
CSCD被引
2
次
|
|
|
|
|
14.
Li B. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression.
Nature,2011,470:535-539
|
CSCD被引
26
次
|
|
|
|
|
15.
Maes M. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression.
Metabolic Brain Disease,2009,24:27-53
|
CSCD被引
19
次
|
|
|
|
|
16.
Matsumoto M. Lateral habenula as a source of negative reward signals in dopamine neurons.
Nature,2007,447:1111-1115
|
CSCD被引
23
次
|
|
|
|
|
17.
Matsumoto M. Representation of negative motivational value in the primate lateral habenula.
Nature Neuroscience,2008,12:77-84
|
CSCD被引
10
次
|
|
|
|
|
18.
Matsumoto M. Two types of dopamine neuron distinctly convey positive and negative motivational signals.
Nature,2009,459:837-841
|
CSCD被引
13
次
|
|
|
|
|
19.
Mayberg H S. Deep brain stimulation for treatment-resistant depression.
Neuron,2005,45:651-660
|
CSCD被引
49
次
|
|
|
|
|
20.
Meng H M. Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression.
Brain Research,2011,1422:32-38
|
CSCD被引
2
次
|
|
|
|
|
了解气象卫星更多信息，请访问