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帕金森病模型大鼠空间学习记忆障碍与SGK表达水平的关系
The impaired learning and memory in rats of Parkinson＇ s disease regulated by the serum and glucocorticoid-inducible kinase
查看参考文献11篇
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文摘
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目的 观察6-羟基多巴胺致帕金森病（PD）大鼠空间学习记忆能力变化及可能的发生机制。方法 6-羟基多巴胺双侧黑质致密部注射4周后进行Morris水迷宫测试；免疫荧光检测海马和前额叶皮质内血清糖皮质激素凋节蛋白激酶（SGK）表达。结果 PD大鼠在第1天水迷宫训练中潜伏期较假手术组（P〈0．05）和正常组（P〈0．05）显著延长。在探测实验中PD大鼠穿台次数[（6．08±1．88）次]，较假手术组[（8．33±0．82）次]和正常组[（9．43±2．57）次]显著减少，同时PD大鼠在站台周围游泳路程占总路程的百分比比正常组明显减少。PD大鼠海马CA1、CA3和前额叶皮质内SGK表达较对照组、假手术组显著减少。结论 PD大鼠存在空间学习记忆障碍。SGK可能参与了大鼠空间记忆障碍的发生机制。 |
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其他语种文摘
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Objective To assess the spatial cognitive ability of Parkinson＇ s disease （PD） rats, using 6- hydroxydopamine administrated in the brain, and further explore the mechanism revolved in the performance. Methods The PD rats＇ learning and memory abilities in the Morris water maze were observed four weeks after 6- hydroxydopamine injected into the compact of Substantia Nigra bilaterally. Immunofluorescence technology was used to detect the ser/glucocorticoid-inducible kinase （SGK） in the hippocampus and prefrontal cortex. Results PD rats spent more time in finding the immerged platform in MWM task in the first training day than sham group （ P =0. 031） and control group （ P=0. 019）. In the probe test, the numbers of PD rats crossing the former platform （6.08 ± 1.88 ）were significantly less than sham group （8.33 ± 0.82） and control group （9.43 ± 2.57 ） and the distance of rats swimming around the platform and total distance were significantly decreased compared with that of control group. Meanwhile, the expression of SGK in CA1 and CA3 of hippocampus and prefrontal cortex significantly decreased. Conclusion PD rats present a deficit in spatial learning and memory in water maze, and the decreased expression of SGK in the hippocampus and prefrontal cortex may be involved in the behaviors. |
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来源
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中国行为医学科学
,2007,16(4):292-295 【扩展库】
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关键词
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帕金森病
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学习记忆
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血清糖皮质激素调节蛋白激酶
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地址
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1.
杭州市第二人民医院神经内科, 杭州, 310015
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中国科学院心理研究所, 中科院脑高级功能实验室
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安徽中医学院附属医院神经内科
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1005-8559 |
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学科
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社会科学总论 |
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基金
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中国博士后科学基金
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文献收藏号
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CSCD:2890236
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