Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives

Shu Lan Zhang Xin Zhai Shi Jiao Zhang Hong Hao Yu Ping Gong ^*

文摘	A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line. Among them, compounds 7c, 7e, l1b, 11f and 11g were more active than Gefitinb against SMMC-7721 cell line
来源	Chinese Chemical Letters ,2010,21(8):939-942 【核心库】
DOI	10.1016/j.cclet.2010.03.016
关键词	Quinoline-3-carbonitrile ; Synthesis ; Cytotoxicity
地址	School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education, Shenyang, 110016
语种	英文
文献类型	研究性论文
ISSN	1001-8417
学科	化学
文献收藏号	CSCD:3968944

参考文献共 8 共1页

	1. Green MR. N. Engl. J. Med,2004,350:2191	CSCD被引 8 次
	2. Ismael G. Cancer Treat. Rev,2008,34:61	CSCD被引 1 次
	3. Liu CY. Ann. Pharmacother,2003,37(11):1644	CSCD被引 2 次
	4. Wissner A. Bioorg. Med. Chem. Lett,2002,12(20):2893	CSCD被引 3 次
	5. Wissner A. J. Med. Chem,2000,43(17):3244	CSCD被引 13 次
	6. Shewchuk L. J. Med. Chem,2000,43(1):133	CSCD被引 4 次
	7. Hu YH. Bioorg. Med. Chem,2006,16(23):6067	CSCD被引 1 次
	8. Khurana JM. Synth. Commun,1992,22:1691	CSCD被引 3 次

引证文献 1 篇

1 Jigar Makawana A Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety Chinese Chemical Letters,2012,23(4):427-430
CSCD被引 6 次

显示所有1篇文献

论文科学数据集

PlumX Metrics

相关文献
作者相关关键词相关参考文献相关

返回检索结果

Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives