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右侧背外侧前额叶皮质在时间知觉中的作用:基于经颅磁刺激的研究
The Role of the Right Dorsolateral Prefrontal Cortex in Time Perception: TMS Evidence

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任维聪 1   王铭维 2   郑志伟 3   张志杰 4 *  
文摘 将10 Hz的重复经颅磁刺激(rTMS)施加于右背外侧前额叶皮质(rDLPFC),探讨该区域在时间加工模型中的作用。实验一采用时间复制任务,通过比较基线和后测条件下时间估计行为的差异,探究高频rTMS离线施加于rDLPFC之后对时间知觉的影响。实验二采用毫秒和秒两种范围的时距,探究rDLPFC在不同范围的时间知觉中的作用。结果发现rTMS施加于rDLPFC导致对1.5 s高估,对600 ms的估计无显著影响,提示rDLPFC在涉及工作记忆加工过程的秒范围的时间知觉中有重要作用。
其他语种文摘 Previous studies claimed the possible role of the right DLPFC in working memory usually based on evidence from lesion and imaging studies. In the present study, we explored the role of the right DLPFC in time processing using the repetitive transcranial magnetic stimulation (rTMS) technique. If the right DLPFC indeed plays a role in working memory function during time perception, the change of activity in this region will have more effects on the supra-second intervals involving working memory function than the sub-second ones. In the fi rst experiment, we explored the role of the right DLPFC in a time reproduction task. The experiment included a baseline condition before rTMS and a post-rTMS condition performed immediately after the cessation of the rTMS train. In each condition, participants need to perform a time reproduction task, which included a time perception and a time reproduction phase. Sixteen undergraduates participated in the rTMS group. Repetitive TMS trains of 10 Hz and 9.5 minutes duration were applied over the right DLPFC of participants. A sham stimuli group (16 participants, without rTMS) was involved to exclude the practice effect and the placebo effect, as well as to test whether the effect of 10 Hz rTMS over the right DLPFC could last to the end of the experiment. To further identify whether the function of the right DLPFC in timing is associated with working memory, we carried out the second experiment with the same rTMS parameters. It is demonstrated that sub-second intervals could be processed depending on the automatic system, while the suprasecond intervals were cognitively controlled, involving the working memory function. Thus the second experiment was a time discrimination task with sub- and supra-second intervals as standard intervals. Twelve undergraduates participated in the time discrimination task, which consisted of two blocks (short vs. long interval block). The two blocks were counterbalanced between participants. All participants were tested both in baseline and post-rTMS conditions. In the control group, no signifi cant differences were found between the baseline and the post-test condition in the reproduction of both standard intervals; while the duration of 1.5 s was over-estimated in the post-rTMS condition, comparing to the baseline condition. In the discrimination task, the point of subjective equality of 1500 ms duration was smaller in the post-rTMS condition than that of baseline condition; no signifi cant differences between baseline and post-rTMS condition were found in the discrimination of 600 ms. The results demonstrated that the right DLPFC played a role in supra-second interval (1500 ms) but not in sub-second interval (600 ms), suggesting it might be involved in the working memory process based on the scaler timing theory. To sum up, the estimation of supra-second interval was affected by the application of rTMS over the right DLPFC in both temporal reproduction and discrimination tasks; meanwhile, it did not affect the discrimination of sub-second interval. The results suggested the important role of the right DLPFC in the working memory function. No signifi cant differences were found between baseline and post-rTMS condition in the estimation of longer interval (4500 ms), which could be estimated with timing strategies.
来源 心理科学 ,2015,38(5):1051-1057 【核心库】
关键词 时间知觉 ; 工作记忆 ; 背外侧前额叶皮质 ; 经颅磁刺激
地址

1. 河北师范大学教育学院, 中国科学院心理健康重点实验室, 石家庄, 050024  

2. 河北省脑老化与认知神经科学实验室, 河北省脑老化与认知神经科学实验室, 石家庄, 050030  

3. 中国科学院心理研究所老年心理研究中心, 中国科学院心理健康重点实验室, 北京, 100101  

4. 河北师范大学教育学院, 河北省脑老化与认知神经科学实验室, 石家庄, 050024

语种 中文
文献类型 研究性论文
ISSN 1671-6981
学科 社会科学总论
基金 河北省自然科学基金
文献收藏号 CSCD:5544285

参考文献 共 25 共2页

1.  Allan L G. The influence of the scalar timing model on human timing research. Behavioural Processes,1998,44:101-117 CSCD被引 10 次    
2.  Ambrus G G. The enhancement of cortical excitability over the DLPFC before and during training impairs categorization in the prototype distortion task. Neuropsychologia,2011,49:1974-1980 CSCD被引 1 次    
3.  Barbey A K. Dorsolateral prefrontal contributions to human working memory. Cortex,2013,49:1195-1205 CSCD被引 13 次    
4.  Basso G. Distributed neural systems for temporal production:A functional MRI study. Brain Research Bulletin,2003,59(5):405-411 CSCD被引 2 次    
5.  Basso D. Prospective memory and working memory:Asymmetrical effects during frontal lobe TMS stimulation. Neuropsychologia,2010,48:3282-3290 CSCD被引 2 次    
6.  Blumenfeld R S. The effects of lateral prefrontal transcranial magnetic stimulation on item memory encoding. Neuropsychologia,2014,53:197-202 CSCD被引 4 次    
7.  Cho S S. Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making. Brain Stimuli,2012,5(2):116-123 CSCD被引 2 次    
8.  Gironell A. Lack of prefrontal repetitive transcranial magnetic stimulation effects in time production processing. European Journal of Neurology,2005,12(11):891-896 CSCD被引 2 次    
9.  Grondin S. From physical time to the first and second moments of psychological time. Psychological Bulletin,2001,127(1):22-44 CSCD被引 3 次    
10.  Jones C R. The right dorsolateral prefrontal cortex is essential in time reproduction:An investigation with repetitive transcranial magnetic stimulation. Experimental Brain Research,2004,158:366-372 CSCD被引 3 次    
11.  Karton I. Facilitating the right but not left DLPFC by TMS decreases truthfulness of object-naming responses. Behavioral Brain Research,2014,271:89-93 CSCD被引 2 次    
12.  Koch G. Underestimation of time perception after repetitive transcranial magnetic stimulation. Neurology,2003,60:1844-1846 CSCD被引 4 次    
13.  Lenartowicz A. Updating of context in working memory:An event-related potential study. Cognitive, Affective, and Behavioural Neuroscience,2010,10(2):298-315 CSCD被引 4 次    
14.  Lewis P A. Brain activity during non-automatic motor production of discrete multi-second intervals. Neuroreport,2002,13:1731-1735 CSCD被引 1 次    
15.  Lewis P A. Distinct systems for automatic and cognitively controlled time measurement:Evidence from neuroimaging. Current Opinion in Neurobiology,2003,13(2):250-255 CSCD被引 21 次    
16.  Lewis P A. A right hemispheric prefrontal system for cognitive time measurement. Behavioural Processes,2006,71:226-234 CSCD被引 3 次    
17.  Maeda F. Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Experimental Brain Research,2000,133:425-430 CSCD被引 13 次    
18.  Makwana A. Stop and be fair:DLPFC development contributes to social decision making. Neuron,2012,73:859-861 CSCD被引 1 次    
19.  Mylius V. Definition of DLPFC and M1 according to anatomical landmarks for navigated brain stimulation:Inter-rater reliability, accuracy, and influence of gender and age. NeuroImage,2013,78:224-232 CSCD被引 3 次    
20.  Poppel E. Lost in time:A historical frame, elementary processing units and the 3~second window. Acta Neurobiology Expression,2004,64:295-301 CSCD被引 3 次    
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