Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives

Yu Fuqiang ^1,2 Guan Aiying ² ^* Li Mengru ² Hu Lan ² Li Xiaowu ¹ ^*

文摘	Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moietywere designed and synthesized. The structures of the title compounds were identified by ~1H NMR, ~(13)C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB)and sorghum anthracnose (SA)were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC_(50) = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC_(50) = 1.03 mg/L), equal to commercial pyraclostrobin (EC_(50) = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development.
来源	Chinese Chemical Letters ,2018,29(6):915-918 【核心库】
DOI	10.1016/j.cclet.2018.01.050
关键词	1,3,4-Oxadiazole derivatives ; Intermediate derivatization method ; Rice sheath blight ; Sorghum anthracnose ; Structure-activity relationship
地址	1. Department of Materials Physics and Chemistry,School of Material Science and Engineering,,Northeastern University, Key Laboratory for Anisotropy and Texture of Materials,Ministry of Education, Shenyang, 110819 2. Shenyang Sinochem Agrochemicals R&D Co.,Ltd., State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang, 110021
语种	英文
文献类型	综述型
ISSN	1001-8417
学科	化学工业
基金	supported partially by the Open Foundation of Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, China
文献收藏号	CSCD:6275686