神经肽Y与创伤后应激障碍神经机制的研究进展
Advances in the study of neuropeptide Y and neural mechanisms of posttraumatic stress disorder
查看参考文献105篇
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文摘
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创伤后应激障碍是指个体直接或间接地暴露于创伤性事件后一段时间内出现的持续性精神障碍,这种障碍会严重影响个体日常生活状态和工作情况。根据研究显示,约1/3的创伤后应激障碍患者终生难愈,自杀率是一般人群的6倍。目前其发病机制尚无定论,临床常规药物疗法效果有限而且副作用明显。与此同时,神经肽Y对于个体应对应激、从创伤性事件中恢复的重要性受到越来越多的关注。本文通过探讨神经肽Y与创伤后应激障碍密切相关的下丘脑-垂体-肾上腺轴、谷氨酸和γ-氨基丁酸神经元、蓝斑-去甲肾上腺素系统以及促肾上腺皮质激素释放激素的关系,初步明确神经肽Y作用的神经环路,可以为预防和治疗创伤后应激障碍以及理解其发生发展机制提供一个新视角。 |
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其他语种文摘
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Post-traumatic stress disorder is a persistent psychological disorder that occurs for a period of time after an individual has been directly or indirectly exposed to a traumatic event,and this disorder can seriously affect the individual's daily living status and work situation. According to studies,about 1/3 of people with PTSD have the disorder for life,and the suicide rate is 6 times higher than that of the general population. The pathogenesis of the disease is still inconclusive,and the effect of conventional clinical drug therapy is limited and has significant side effects. At the same time,increasing attention has been paid to the importance of neuropeptide Y (NPY)for individuals to cope with stress and recover from traumatic events. In this paper,we explore the relationship between neuropeptide Y and the hypothalamic-pituitary-adrenal axis,Glutamate and γ-aminobutyric acid neurons,locus coeruleusnorepinephrine system,and corticotropin releasing factor,which are closely related to posttraumatic stress disorder,to identify the neural circuit of neuropeptide Y. It may provide a new perspective for the prevention and treatment of PTSD and for the understanding of its developmental mechanisms. |
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来源
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中国临床药理学与治疗学
,2021,26(7):814-823 【扩展库】
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DOI
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10.12092/j.issn.1009-2501.2021.07.014
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关键词
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创伤后应激障碍
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神经肽Y
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神经机制
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地址
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1.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
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中国科学院大学心理学系, 北京, 100049
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1009-2501 |
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学科
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神经病学与精神病学 |
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基金
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中国科学院心理健康重点实验室开放课题
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文献收藏号
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CSCD:7024942
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参考文献 共
105
共6页
|
|
1.
Fenster R J. Brain circuit dysfunction in post-traumatic stress disorder: From mouse to man.
Nat Rev Neurosci,2018,19(9):535-551
|
CSCD被引
6
次
|
|
|
|
|
2.
Jordan N N. Mental health impact of 9/11 pentagon attack validation of a rapid assessment tool.
Am J Prev Med,2004,26(4):284-293
|
CSCD被引
14
次
|
|
|
|
|
3.
American Psychiatric A.
Diagnostic and statistical manual of mental disorders,2013
|
CSCD被引
23
次
|
|
|
|
|
4.
Orr S P. Psychophysiological assessment of posttraumatic stress disorder imagery in world war ii and korean combat veterans.
J Abnorm Psychol,1993,102(1):152-159
|
CSCD被引
1
次
|
|
|
|
|
5.
Sah R. Neuropeptide y and posttraumatic stress disorder.
Mol Psychiatry,2013,18(6):646-655
|
CSCD被引
3
次
|
|
|
|
|
6.
Association A P.
The road to resilience,2014
|
CSCD被引
2
次
|
|
|
|
|
7.
Southwick S M. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder.
Biol Psychiatry,1999,46(9):1192-1204
|
CSCD被引
7
次
|
|
|
|
|
8.
Yehuda R. Current status of cortisol findings in posttraumatic stress disorder.
Psychiatr Clin North Am,2002,25(2):341-368,vii
|
CSCD被引
4
次
|
|
|
|
|
9.
O'Donnell T. Noradrenergic mechanisms in the pathophysiology of posttraumatic stress disorder.
Neuropsychobiology,2004,50(4):273-283
|
CSCD被引
8
次
|
|
|
|
|
10.
Yehuda R. Neuroendocrine aspects of ptsd.
Handb Exp Pharmacol,2005,169(169):371-403
|
CSCD被引
1
次
|
|
|
|
|
11.
Strawn J R. Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder.
Depress Anxiety,2008,25(3):260-271
|
CSCD被引
4
次
|
|
|
|
|
12.
Pang Z Y. A knowledge-mapping analysis of U.S. Research on treatments for children and adolescents with post-traumatic stress disorder (ptsd).
Adv Psychol Sci,2017,25(7)
|
CSCD被引
1
次
|
|
|
|
|
13.
宋大可.
抗创伤后应激障碍候选药物及其可能机制研究,2019
|
CSCD被引
1
次
|
|
|
|
|
14.
Kautz M. Neuropeptide y, resilience,and ptsd therapeutics.
Neurosci Lett,2017,649:164-169
|
CSCD被引
2
次
|
|
|
|
|
15.
Frans O. Trauma exposure and post-traumatic stress disorder in the general population.
Acta Psychiatr Scand,2005,111(4):291-299
|
CSCD被引
2
次
|
|
|
|
|
16.
Koenen K C. Posttraumatic stress disorder in the world mental health surveys.
Psychol Med,2017,47(13):2260-2274
|
CSCD被引
16
次
|
|
|
|
|
17.
Kilpatrick D G. National estimates of exposure to traumatic events and ptsd prevalence using dsm-iv and dsm-5 criteria.
J Trauma Stress,2013,26(5):537-547
|
CSCD被引
4
次
|
|
|
|
|
18.
Martin-Soelch C. Editorial: resilience and vulnerability factors in response to stress.
Front Psychiatry,2019,10:732
|
CSCD被引
1
次
|
|
|
|
|
19.
Masten A S. Resilience in individual development: Successful adaptation despite risk and adversity.
Educational resilience in inner-city america: Challenges and prospects,1994:3-25
|
CSCD被引
1
次
|
|
|
|
|
20.
Pervanidou P.
Neuroendocrinology of post-traumatic stress disorder. Neuroendocrinology-pathological situations and diseases,2010:149-160
|
CSCD被引
1
次
|
|
|
|
|
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