Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death
查看参考文献33篇
文摘
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Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer.Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis.Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential drugs for cancer treatment.In the present study, we investigated the antiangiogenic activity of a series of monocarbonyl analogs of curcumin synthesized previously in our lab.We found that curcumin analog A2 displayed the full potential to be developed as a novel antiangiogenic agent.Curcumin analog A2 at and above 20 μM dramatically inhibited the migration and tube formation of human umbilical vein endothelial cells(HUVECs)in vitro, new microvessels sprouting from the rat aortic rings ex vivo and newly formed microvessels in chicken chorioallantoic membranes(CAMs)and Matrigel plus in vivo.We further demonstrated that curcumin analog A2 exerted its antiangiogenic activity mainly through inducing endothelial cell death via elevating NADH/NADPH oxidase-derived ROS.Curcumin analog A2 at the antiangiogenic concentrations also triggered autophagy in HUVECs, but this process is neither a pre-requisite for toxicity, leading to the cell death nor a protective response against the toxicity of curcumin analog A2.In conclusion, we demonstrate for the first time the potent antiangiogenic activity of the monocarbonyl curcumin analog A2, which could serve as a promising potential therapeutic agent for the prevention and treatment angiogenesis-related diseases, such as cancer. |
来源
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Acta Pharmacologica Sinica
,2019,40(11):1412-1423 【核心库】
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DOI
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10.1038/s41401-019-0224-x
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关键词
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monocarbonyl curcumin analog
;
angiogenesis
;
apoptosis
;
autophagy
;
necroptosis
;
reactive oxygen species
;
vascular endothelial cell
;
bafilomycin A1
;
wortmannin
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地址
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1.
College of Bioengineering, Henan University of Technology, Zhengzhou, 450001
2.
Morphological laboratory, Xinxiang Medical University, Xinxiang, 453003
3.
Lanzhou University, State Key Laboratory of Applied Organic Chemistry, Lanzhou, 730000
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语种
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英文 |
文献类型
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研究性论文 |
ISSN
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1671-4083 |
学科
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医药、卫生 |
基金
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国家自然科学基金
;
the Foundation for Key Teacher by Henan University of Technology
;
the Research Program for Science and Technology of Henan Province
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文献收藏号
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CSCD:6609381
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参考文献 共
33
共2页
|
1.
Potente M. Basic and therapeutic aspects of angiogenesis.
Cell,2011,146:873-887
|
被引
95
次
|
|
|
|
2.
De Palma M. Microenvironmental regulation of tumour angiogenesis.
Nat Rev Cancer,2017,17:457-474
|
被引
63
次
|
|
|
|
3.
Hida K. Understanding tumor endothelial cell abnormalities to develop ideal anti-angiogenic therapies.
Cancer Sci,2008,99:459-466
|
被引
5
次
|
|
|
|
4.
Noble M E. Protein kinase inhibitors: insights into drug design from structure.
Science,2004,303:1800-1805
|
被引
22
次
|
|
|
|
5.
Rahmani A H. Role of curcumin in disease prevention and treatment.
Adv Biomed Res,2018,7:38
|
被引
2
次
|
|
|
|
6.
Shanmugam M K. Potential role of natural compounds as anti-angiogenic agents in cancer.
Curr Vasc Pharmacol,2017,15:503-519
|
被引
2
次
|
|
|
|
7.
El-Azab M. Anti-angiogenic effect of resveratrol or curcumin in Ehrlich ascites carcinoma-bearing mice.
Eur J Pharmacol,2011,652:7-14
|
被引
3
次
|
|
|
|
8.
Gururaj A E. Molecular mechanisms of anti-angiogenic effect of curcumin.
Biochem Biophys Res Commun,2002,297:934-942
|
被引
23
次
|
|
|
|
9.
Hewlings S J. Curcumin: A review of its’effects on human health.
Foods,2017,6:E92
|
被引
22
次
|
|
|
|
10.
Shimazu K. Curcumin analog GOY078, overcomes resistance to tumor angiogenesis inhibitors.
Cancer Sci,2018,109:3285-3293
|
被引
1
次
|
|
|
|
11.
Sugiyama S. A curcumin analog, GO-Y078, effectively inhibits angiogenesis through actin disorganization.
Anticancer Agents Med Chem,2016,16:633-647
|
被引
1
次
|
|
|
|
12.
Sun L. Potent anti-angiogenicactivity of B19—a mono-carbonyl analogue of curcumin.
Chin J Nat Med,2014,12:8-14
|
被引
2
次
|
|
|
|
13.
Zhao C. Promising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs).
Curr Pharm Des,2013,19:2114-2135
|
被引
5
次
|
|
|
|
14.
Pan Z. Synthesis and cytotoxic evaluation of monocarbonyl analogs of curcumin as potential anti-tumor agents.
Drug Dev Res,2016,77:43-49
|
被引
1
次
|
|
|
|
15.
Pignanelli C. Selective targeting of cancer cells by oxidative vulnerabilities with novel curcumin analogs.
Sci Rep,2017,7:1105
|
被引
1
次
|
|
|
|
16.
Song J X. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Autophagy,2016,12:1372-1389
|
被引
15
次
|
|
|
|
17.
Jaffe E A. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.
J Clin Invest,1973,52:2745-2756
|
被引
278
次
|
|
|
|
18.
Zhang L. 3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells.
J Cell Biochem,2013,114:697-707
|
被引
1
次
|
|
|
|
19.
Zhang L. Magnetic ferroferric oxide nanoparticles induce vascular endothelial cell dysfunction and inflammation by disturbing autophagy.
J Hazard Mater,2016,304:186-195
|
被引
5
次
|
|
|
|
20.
Zhang L. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells.
Biochim Biophys Acta,2015,1853:377-387
|
被引
3
次
|
|
|
|
|