多孔钽植入物在骨缺损中的应用进展
Research progress in application of porous tantalum implant for treatment of bone defects
查看参考文献86篇
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文摘
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多孔金属钽具有良好的生物相容性与骨传导能力,相比于传统的金属植入物材料有较低的弹性模量与高的摩擦因数,可以避免发生应力遮挡效应且具有与人类松质骨类似的多孔结构。多孔钽的力学性能优势与优秀的生物学性能,在骨修复材料领域受到越来越多的关注,且已研发并应用于多种部位的骨缺损修复中。随着多孔钽材料制备方法的更新与多种改性方法的提出,多孔钽进一步展示了在临床应用中的广阔前景。本文从多孔钽材料的制备工艺、细胞毒性、与骨结合特性以及目前在临床的应用情况等方面,介绍多孔钽植入物在骨缺损中的应用进展,并提出了多孔钽在表面改性建立复合体系、优化制备工艺及个性化制备技术的发展方向,为多孔钽植入物在治疗骨缺损的临床应用提供参考。 |
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其他语种文摘
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Porous tantalum metal has good biocompatibility and osteoconductivity,with a lower modulus of elasticity and a higher coefficient of friction to avoid stress-shielding compared with traditional implant metal materials. In addition, its porous structure, similar to that of human cancellous bone. Porous tantalum has received increasing attention in recent years due to its advantages in mechanical properties and excellent biological properties,and has been developed and applied in the treatment of various bone defects. With the progress of the preparation methods of porous tantalum materials and the proposal of various modification methods,the prosperity of porous tantalum in clinical applications has been further demonstrated. In this paper, the application of porous tantalum implant in bone defects treatment was reviewed, considering its preparation technology,cytotoxicity,osseointegration properties, and current clinical applications. Furthermore, the developments of porous tantalum including surface modification for establishing composite systems, optimization of preparation processes and personalized preparation techniques are expected to facilitate the clinical application of porous tantalum implants in the treatment of bone defects. |
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来源
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材料工程
,2022,50(11):1-13 【核心库】
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DOI
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10.11868/j.issn.1001-4381.2021.001151
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关键词
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多孔钽
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骨缺损
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骨植入物
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临床应用
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地址
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1.
上海交通大学生物医学工程学院, 上海, 200030
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上海交通大学医学院附属第九人民医院骨科, 上海, 200011
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1001-4381 |
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学科
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基础医学 |
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基金
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上海市浦江人才计划项目
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上海交通大学医工交叉青年项目
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文献收藏号
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CSCD:7398754
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