Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
查看参考文献74篇
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文摘
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In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria ( <3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG. |
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来源
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Frontiers of Medicine
,2017,11(3):340-348 【核心库】
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DOI
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10.1007/s11684-017-0570-3
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关键词
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obesity-related glomerulopathy
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pathogenesis
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pathologic
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clinical characteristics
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地址
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Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001
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语种
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英文 |
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文献类型
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综述型 |
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ISSN
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2095-0217 |
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学科
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医药、卫生 |
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文献收藏号
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CSCD:6114021
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74
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