表观扩散系数值评估较低级别胶质瘤IDH-1突变状态和瘤细胞增殖活性的价值
The value of apparent diffusion coefficient value in evaluating the IDH-1 mutation status and tumor cell proliferation activity of lower-grade gliomas
查看参考文献32篇
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文摘
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目的探讨表观扩散系数(apparent diffusion coefficient, ADC)值在较低级别胶质瘤(lower-grade gliomas, LGG)异柠檬酸脱氢酶-1(isocitrate dehydrogenase 1, IDH-1)突变状态和瘤细胞增殖活性中的评估价值。材料与方法回顾性分析经病理证实并测定IDH-1突变状态和Ki-67增殖指数的44例LGG患者病例,其中IDH-1突变型24例,IDH-1野生型20例。在ADC图上测量病灶实质的最小ADC值(ADC_(min))、平均ADC值(ADC_(mean))和对侧镜像正常脑白质的ADC值,计算相对最小ADC值(rADC_(min))和相对平均ADC值(rADC_(mean))。比较LGG IDH-1突变型和IDH-1野生型组间各ADC值间差异,绘制受试者工作特征(receiver operating characteristic, ROC)曲线分析各ADC值对IDH-1突变状态的评估效能,并分析其与Ki-67增殖指数间的相关性。结果IDH-1突变型组的ADC_(min)、ADC_(mean)、rADC_(min)和rADC_(mean)值均高于IDH-1野生型组,组间差异具有统计学意义(P均<0.05)。ROC曲线结果显示各参数均能对IDH-1突变型和IDH-1野生型LGG进行有效区分,其中,rADC_(min)鉴别效能最佳,以0.978为最佳截止值,相应的曲线下面积(area under the curve, AUC)、敏感度、特异度、准确度、阳性预测值和阴性预测值分别为0.838、80.00%、83.33%、81.82%、80.00%和83.30%。LGG ADC_(min)、ADC_(mean)、rADC_(min)和rADC_(mean)与Ki-67增殖指数间均呈不同程度的负相关关系(r=-0.552、-0.590、-0.532、-0.579,P均<0.05)。结论ADC值可用于评估LGG IDH-1突变状态,对于肿瘤细胞增殖活性的评估也具有一定的价值。 |
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其他语种文摘
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Objective: To investigate the evaluation value of apparent diffusion coefficient(ADC)value in lower-grade gliomas(LGG) isocitrate dehydrogenase 1(IDH-1)mutation status and tumor cell proliferation activity. Materials and Methods: Forty-four patient cases with LGG were confirmed by pathology, and measured IDH-1 mutation status and the Ki-67 proliferation index was retrospectively analyzed, including 24 cases of IDH-1 mutant-type and 20 cases of IDH-1 wild-type. The minimum ADC value(ADC_(min)), mean ADC value(ADC_(mean))of the lesion parenchyma, and the ADC value of the contralateral mirror normal white matter on the ADC maps were measured, and the relative minimum ADC value(rADC_(min))and relative mean ADC value(rADC_(mean))were calculated. The differences in ADC values between the two groups were compared, and receiver operating characteristic(ROC)curves were drawn to evaluate the differential diagnostic efficacy. The Ki-67 proliferation index of the solid tumor components was also measured to explore its relationship with ADC values. Results: The ADC_(min), ADC_(mean), rADC_(min), and rADC_(mean) values in the IDH-1 mutant-type group were higher than those in the IDH-1 wild-type group, and the differences between the groups were statistically significant(all P<0.05). ROC results show that all parameters can effectively distinguish IDH-1 mutant-type and IDH-1 wild-type LGG. Among them, rADC_(min) has the best discrimination efficiency, and 0.978 is the best cut-off value, with area under the curve(AUC), sensitivity, specificity, accuracy, positive predictive value, and negative predictive value was 0.838, 80.00%, 83.33%, 81.82%, 80.00%, and 83.30%, respectively. ADC_(min), ADC_(mean), rADC_(min), rADC_(mean) and Ki-67 proliferation index showed different degrees of negative correlation(r=-0.552,-0.590,-0.532,-0.579, all P<0.05). Conclusions: ADC values can be used to evaluate LGG IDH-1 mutation status, and it also has a certain value for evaluating tumor cell proliferation activity. |
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来源
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磁共振成像
,2022,13(8):13-18 【核心库】
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DOI
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10.12015/issn.1674-8034.2022.08.003
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关键词
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脑胶质瘤
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较低级别胶质瘤
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异柠檬酸脱氢酶
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Ki-67增殖指数
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磁共振成像
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表观扩散系数
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地址
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兰州大学第二医院放射科, 兰州大学第二临床医学院, 甘肃省医学影像重点实验室;;医学影像人工智能甘肃省国际科技合作基地, 兰州, 730030
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1674-8034 |
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学科
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临床医学;肿瘤学 |
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基金
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国家自然科学基金
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甘肃省自然科学基金
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甘肃省医学影像重点实验室开放基金
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文献收藏号
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CSCD:7270382
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