Design, synthesis and biological evaluation of 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

Sun Rui ¹ Song Jing ¹ Liu Sijie ¹ Zhao Hui ¹ Yan Chunli ¹ Zhang Aijun ¹ Diwa Koirala ² Li Dawei ² Hu Chun ¹ ^*

文摘	The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1,4-Dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists
来源	Chinese Chemical Letters ,2011,22(3):256-259 【核心库】
DOI	10.1016/j.cclet.2010.10.029
关键词	Estrogen receptor antagonists ; Synthesis ; Biological activity ; Thiophene ; Pyrazole ; Thiopyran ; Piperazine
地址	1. Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China, Shenyang, 110016 2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 300193
语种	英文
文献类型	研究性论文
ISSN	1001-8417
学科	化学
基金	国家自然科学基金
文献收藏号	CSCD:4149926

参考文献共 4 共1页

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Design, synthesis and biological evaluation of 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists