Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis:time to expand the M categorization system
查看参考文献32篇
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文摘
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Introduction:The current metastatic category (M) of nasopharyngeal carcinoma (NPC) is a “catch-all” classification, covering a heterogeneous group of tumors ranging from potentially curable to incurable. The aim of this study was to design an M categorization system that could be applied in planning the treatment of NPC with synchronous metastasis. Methods:A total of 505 NPC patients diagnosed with synchronous metastasis at Sun Yat-sen University Cancer Center between 2000 and 2009 were involved. The associations of clinical variables, metastatic features, and a proposed M categorization system with overall survival (OS) were determined by using Cox regression model. Results:Multivariate analysis showed that Union for International Cancer Control (UICC) N category (N1-3/N0), number of metastatic lesions (multiple/single), liver involvement (yes/no), radiotherapy to primary tumor (yes/no), and cycles of chemotherapy (>4/≤4) were independent prognostic factors for OS. We defined the following subcategories based on liver involvement and the number of metastatic lesions:M1a, single lesion confined to an isolated organ or location except the liver; M1b, single lesion in the liver and/or multiple lesions in any organs or locations except the liver; and M1c, multiple lesions in the liver. Of the 505 cases, 74 (14.7%) were classified as M1a, 296 (58.6%) as M1b, 134 (26.5%) as M1c, and 1 was not specified. The three M1 subcategories showed significant difference in OS [M1b vs. M1a, hazard ratio (HR) = 1.69, 95% confidence interval (CI) = 1.16-2.48, P = 0.007; M1c vs. M1a, HR = 2.64, 95% CI = 1.75-3.98, P < 0.001]. Conclusions:We developed an M categorization system based on the independent factors related to the prognosis of patients with metastatic NPC. This system may be helpful to further optimize individualized care for NPC patients. |
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来源
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Chinese Journal of Cancer
,2015,34(10):450-458 【核心库】
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DOI
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10.1186/s40880-015-0031-9
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关键词
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Nasopharyngeal carcinoma
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TNM staging
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Metastasis
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Prognosis
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地址
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1.
Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China;;Collaborative Innovation Center for Cancer Medicine, Guangdong, Guangzhou, 510060
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Department of Radiation Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Guangdong, Zhuhai, 519000
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Department of Radiation Oncology, Cancer Center of Guangzhou Medical University, Guangdong, Guangzhou, 510080
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Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China;;Collaborative Innovation Center for Cancer Medicine, Guangdong, Guangzhou, 510060
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Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan, Chengdu, 610041
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1000-467X |
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学科
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肿瘤学 |
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基金
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supported by the Grant from National High Technology Research and Development Program of China (863 Program)
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文献收藏号
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CSCD:5545530
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参考文献 共
32
共2页
|
|
1.
Greene F L. The staging of cancer: a retrospective and prospective appraisal.
CA Cancer J Clin,2008,58(3):180-190
|
CSCD被引
7
次
|
|
|
|
|
2.
Gospodarowicz M K. The process for continuous improvement of the TNM classification.
Cancer,2004,100(1):1-5
|
CSCD被引
16
次
|
|
|
|
|
3.
Ng W T. Staging of nasopharyngeal carcinoma- the past, the present and the future.
Oral Oncol,2014,50(6):549-554
|
CSCD被引
7
次
|
|
|
|
|
4.
Ouyang P Y. Comparison of TNM staging systems for nasopharyngeal carcinoma, and proposal of a new staging system.
Br J Cancer,2013,109(12):2987-2997
|
CSCD被引
5
次
|
|
|
|
|
5.
Shi Q. Involvement of both cervical lymph nodes and retropharyngeal lymph nodes has prognostic value for N1 patients with nasopharyngeal carcinoma.
Radiat Oncol,2014,9:7
|
CSCD被引
4
次
|
|
|
|
|
6.
Yang Z. Relationship between dynamic contrast-enhanced and perfusion magnetic resonance imaging and T-staging of nasopharyngeal carcinoma.
Zhonghua Yi Xue Za Zhi, (in Chinese),2013,93(15):1153-1155
|
CSCD被引
1
次
|
|
|
|
|
7.
Young L S. Epstein-Barr virus and nasopharyngeal carcinoma.
Chin J Cancer,2014,33(12):581-590
|
CSCD被引
18
次
|
|
|
|
|
8.
Fandi A. Longterm disease-free survivors in metastatic undifferentiated carcinoma of nasopharyngeal type.
J Clin Oncol,2000,18(6):1324-1330
|
CSCD被引
10
次
|
|
|
|
|
9.
Chou C W. Prolonged survival in a nasopharyngeal carcinoma patient with multiple metastases: a case report and review of the literature.
Jpn J Clin Oncol,1997,27(5):336-339
|
CSCD被引
1
次
|
|
|
|
|
10.
Wang C T. Prognosis analysis of nasopharyngeal carcinoma patients with distant metastasis.
Ai Zheng, (in Chinese),2007,26(2):212-215
|
CSCD被引
1
次
|
|
|
|
|
11.
Setton J. Definitive treatment of metastatic nasopharyngeal carcinoma: report of 5 cases with review of literature.
Head Neck,2012,34(5):753-757
|
CSCD被引
9
次
|
|
|
|
|
12.
Ong Y K. Design of a prognostic index score for metastatic nasopharyngeal carcinoma.
Eur J Cancer,2003,39(11):1535-1541
|
CSCD被引
12
次
|
|
|
|
|
13.
Hui E P. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group.
Cancer,2004,101(2):300-306
|
CSCD被引
17
次
|
|
|
|
|
14.
Pan C C. Challenges in the modification of the M1 stage of the TNM staging system for nasopharyngeal carcinoma: a study of 1027 cases and review of the literature.
Exp Ther Med,2012,4(2):334-338
|
CSCD被引
8
次
|
|
|
|
|
15.
Tian Y M. Prognostic factors in nasopharyngeal carcinoma with synchronous liver metastasis: a retrospective study for the management of treatment.
Radiat Oncol,2013,8:272
|
CSCD被引
4
次
|
|
|
|
|
16.
Li J X. Prognostic factors on overall survival of newly diagnosed metastatic nasopharyngeal carcinoma.
Asian Pac J Cancer Prev,2014,15(7):3169-3173
|
CSCD被引
2
次
|
|
|
|
|
17.
Pan C C. Comparative survival analysis in patients with pulmonary metastases from nasopharyngeal carcinoma treated with radiofrequency ablation.
Eur J Radiol,2012,81(4):e473-e477
|
CSCD被引
10
次
|
|
|
|
|
18.
Jin Y. Radiofrequency ablation combined with systemic chemotherapy in nasopharyngeal carcinoma liver metastases improves response to treatment and survival outcomes.
J Surg Oncol,2012,106(3):322-326
|
CSCD被引
11
次
|
|
|
|
|
19.
Teo P M. Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma.
Cancer,1996,77(12):2423-2431
|
CSCD被引
21
次
|
|
|
|
|
20.
Lin S. Combined high-dose radiation therapy and systemic chemotherapy improves survival in patients with newly diagnosed metastatic nasopharyngeal cancer.
Am J Clin Oncol,2012,35(5):474-479
|
CSCD被引
11
次
|
|
|
|
|
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