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文摘
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为了研究柴达木盆地唐古特白刺果实的降血脂、抗氧化作用，本文采用高脂饲料诱导小鼠和大鼠 建立高脂动物模型，灌胃给药4周，测定各组实验动物的血清血脂水平，并测定大鼠红细胞SOD活性和血清脂质过氧化物（LPO）分解产物丙二醛（MDA）的含量变化。结果显示唐古特白刺果实1.8g/kg和3.6g/kg剂量对高脂饲料诱导的小鼠和大鼠血清TC、TG及大鼠的LDL具有显著的抑制作用；同时可显著升高高血脂大鼠HDL/TC和HDL/LDL的比值，提高高血脂大鼠SOD活力和降低高血脂大鼠MDA含量；对大鼠体重和正常小鼠血脂水平无明显影响。表明唐古特白刺果实具有降血脂、防治动脉粥样硬化和抗氧化作用。 |
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其他语种文摘
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To study on decreasing blood lipid and anti-oxidative effect of fruit of Nitraria tangutorum Bobr. from Qinghai Qaidam Basin, the blood lipid levels in serum of each animal group were determined after oral ad-ministration for 4 weeks, with the hyperlipemia models of Wistar rat and Kunming strain mice induced by feed with high lipids. Moreover, the SOD activity in red cells, and the content of MDA, which is decomposed from lipo-peroxide (LPO) in serum, were determined as well. It showed that the fruit of Nitraria tangutorum Bo-br. at the dose of 1.8 g/kg and 3.6 g/kg not only had significant inhibition effect on TC and TG levels in serum of the hyperlipemia model of Wistar rat and Kunming strain mice and LDL level in serum of hyperlipemia model of Wister rat, but also increased the ratio of HDL/TC and HDL/LDL, and SOD activity, and decreased the MDA content of the hyperlipemia model of Wistar rat, significantly. However, it had no significant effect on the weight of Wistar rat and lipidemia level of normal mice. The fruit of Nitraria tangutorum Bobr. has better decreasing blood lipid and anti-oxidative effect, and can prevent and cure atherosclerosis. |
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来源
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天然产物研究与开发
,2004,16(1):54-58 【核心库】
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关键词
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唐古特白刺果实
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降血脂
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抗氧化
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地址
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1.
中国科学院兰州化学物理研究所, 兰州, 730000
2.
中国科学院西北高原生物研究所, 西宁, 810001
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1001-6880 |
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基金
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国家财政部西部高新技术成果转化专项基金
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文献收藏号
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CSCD:1509152
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