Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

Zhao Yanfang Liu Zijian Zhai Xin Ge Dandan Huang Qiang Gong Ping ^*

文摘	A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_(50) values of 0.016,0.63,0.001μmol/L, respectively.
来源	Chinese Chemical Letters ,2013,24(5):386-388 【核心库】
DOI	10.1016/j.cclet.2013.02.004
关键词	Diaryl ureas ; Synthesis ; Antitumor activity in vitro
地址	School of Pharmaceutical Engineering. Shenyang Pharmaceutical University, Key Lab of New Drugs Design and Discovery of Liaoning Province, Shenyang, 110016
语种	英文
文献类型	研究性论文
ISSN	1001-8417
学科	化学工业
基金	supported by a grant from the National Natural Science Foundation of China
文献收藏号	CSCD:4846555

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引证文献 2 篇

1 Nagarajan Sangaraiah An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents Chinese Chemical Letters,2014,25(3):419-422
CSCD被引 0 次

2 Wang Ke Synthesis and in vitro cytotoxic activities of sorafenib derivatives Chinese Chemical Letters,2014,25(5):702-704
CSCD被引 0 次

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Synthesis and in vitro antitumor activity of novel diaryl urea derivatives