LncRNAs in DNA damage response and repair in cancer cells
查看参考文献107篇
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文摘
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In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/ repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo- and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (IncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of IncRNAs in regulating the cellular response to DNA damage. |
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来源
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Acta Biochimica et Biophysica Sinica
,2018,50(5):433-439 【核心库】
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DOI
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10.1093/abbs/gmy022
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关键词
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DNA damage response
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apoptosis
;
cell cycle
;
cancer
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IncRNA
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地址
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1.
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, 410013
2.
Department of Medical Microbiology, Immunology & Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, USA, Springfield, 62794
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1672-9145 |
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基金
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supported in part by the grants from the National Natural Science Foundation of China
;
湖南省自然科学基金
;
the Scientific Research Foundation of the Health and Family Planning Commission of Hunan Province
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文献收藏号
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CSCD:6252625
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107
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