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文摘
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It has long been a dream to achieve tumor targeting therapy that can efficiently reduce the toxicity and severe side effects of conventional antitumor chemotherapeutic agents. Taking advantage of the abnormalities of tumor vasculature, we demonstrate here a new powerful tumor vascular-targeting therapeutic technique for solid cancers that applies advanced nanotechnology to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels. Water soluble magnetic Gd@C_(82) nanocrystals of the chosen sizes are deliberately designed with abilities to penetrate into the leaky tumor blood vessels. By triggering the radiofrequency induced phase transition of gadofullerene nanocrystals while extravasating the tumor blood vessel, the explosive structural change of nanoparticles generates a devastating impact on abnormal tumor blood vessels, resulting in a rapid and extensive ischemia necrosis and shrinkage of the tumors. This unprecedented target-specific physiotherapy is found to work perfectly for advanced and refractory solid tumors. |
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其他语种文摘
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本文报道了一种利用金属富勒烯纳米晶体快速高效治疗肿瘤的新技术. 从生物学上肿瘤血管和正常血管在结构上存在显著差异这一特点着手, 利用材料学上金属富勒烯纳米晶体在吸收射频能量后发生相变, 伴随着体积剧烈膨胀的特性, 高选择性地摧毁肿瘤血管. 研究表明, 经过1小时治疗后, 肿瘤部位血流即可发生快速阻断, 治疗2~4小时后, 肿瘤组织逐步发生出血性坏死, 肿瘤塌陷体积缩小; 并且对于多种实体肿瘤均有显著疗效. 该技术是一种快速、广谱、特异性高、毒副作用小的新型肿瘤治疗技术, 是一种具有巨大发展潜力的肿瘤治疗技术. |
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来源
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Science China. Materials
,2015,58(10):799-810 【核心库】
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DOI
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10.1007/s40843-015-0089-3
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地址
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1.
Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences;;Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing, 100190
2.
University of Science and Technology of China, Bio-X Division, Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information & Quantum Physics, Hefei, 230026
3.
Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan, 430071
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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2095-8226 |
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学科
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肿瘤学 |
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基金
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the Key Research Program of the Chinese Academy of Sciences
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国家自然科学基金
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文献收藏号
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CSCD:5551309
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