肝脏胰岛素抵抗与2型糖尿病
Hepatic Insulin Resistance and Type 2 Diabetes Mellitus
查看参考文献88篇
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文摘
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胰岛素抵抗(insulin resistance,IR)是因肝脏等靶组织对胰岛素敏感下降导致高胰岛素血症、糖耐量受损的一种病理性反应。IR作为2型糖尿病典型的病理特征,其发病机制是抗糖尿病研究的焦点。本文就糖尿病状态下的糖代谢、脂代谢、氧化应激、线粒体功能障碍、内质网应激、炎症与肝脏胰岛素抵抗相关信号通路的分子生物学机制进行综述,为糖尿病治疗提供新思路及理论指导。 |
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其他语种文摘
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Insulin resistance (IR) is a pathological reaction of hyperinsulinemia and impaired glucose tolerance caused by decreased sensitivity of target tissues such as liver to insulin. The pathogenesis of IR as a typical pathological feature of type 2 diabetes is the focus of anti-diabetes research. In this paper,we reviewed the molecular mechanisms of glucose and lipid metabolism,oxidative stress,mitochondrial dysfunction,endoplasmic reticulum stress,inflammation,and hepatic IR in the case of type 2 diabetes mellitus,which might provide new ideas and theoretical guidance for the treatment of diabetes mellitus. |
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来源
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中国医学科学院学报
,2022,44(4):699-708 【核心库】
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DOI
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10.3881/j.issn.1000-503X.13662
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关键词
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糖尿病
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肝脏
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胰岛素抵抗
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信号通路
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作用机制
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地址
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新疆大学生命科学与技术学院, 新疆生物资源基因工程重点实验室, 乌鲁木齐, 830046
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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基础医学 |
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基金
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新疆自然科学基金青年基金项目
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新疆维吾尔自治区重点实验室开放课题
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文献收藏号
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CSCD:7291133
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参考文献 共
88
共5页
|
|
1.
Magliano D J.
IDF diabetes Atlas 10th edition 2021,2021
|
被引
2
次
|
|
|
|
|
2.
Li H. PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway.
Exp Cell Res,2019,381(1):301-310
|
被引
1
次
|
|
|
|
|
3.
Lei C. Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells.
Food Chem Toxicol,2019,127(1):182-187
|
被引
1
次
|
|
|
|
|
4.
Ren N. Flavonoids alleviating insulin resistance through inhibition of inflammatory signaling.
J Agric Food Chem,2019,67(19):5361-5373
|
被引
2
次
|
|
|
|
|
5.
Matthew J W. The liver as an endocrine organlinking NAFLD and insulin resistance.
Endocr Rev,2019,40(5):1367-1393
|
被引
20
次
|
|
|
|
|
6.
Zhao X. High-throughput sequencing of small RNAs and analysis of differentially expressed microRNAs associated with high-fat diet induced hepatic insulin resistance in mice.
Genes Nutr,2019,14(6):1-11
|
被引
1
次
|
|
|
|
|
7.
Goldstein I. Transcriptional and chromatin regulation during fasting the genomic era.
Trends Endocrinol Metab,2015,26:699-710
|
被引
2
次
|
|
|
|
|
8.
Lee J. Insulin receptor activation with transmembrane domain ligands.
J Biol Chem,2014,289(1):19769-19777
|
被引
1
次
|
|
|
|
|
9.
Feier C. D-chiro-Inositol ameliorates high fat diet-induced hepatic steatosis and insulin resistance via PKCε-PI3K/AKT pathway.
J Agric Food Chem,2019,67(21):5957-5967
|
被引
1
次
|
|
|
|
|
10.
Yang R Y. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A.
Int J Mol Med,2018,42(5):2329-2342
|
被引
4
次
|
|
|
|
|
11.
Chen W. Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue.
J Ginseng Res,2016,40(4):351-358
|
被引
7
次
|
|
|
|
|
12.
Pentassuglia L. Neuregulin1β promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes.
Am J Physiol Endocrinol Metab,2016,310(9):782-794
|
被引
3
次
|
|
|
|
|
13.
Zhao H. Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro.
Drug Des Devel Ther,2019,13(1):1473-1485
|
被引
3
次
|
|
|
|
|
14.
Sajad A M. Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation.
Free Radic Res,2019,53(7):815-827
|
被引
9
次
|
|
|
|
|
15.
Xiao C. Antidiabetic activity of Ganoderma lucidum polysaccharides F31 downregulated hepatic glucose regulatory enzymes in diabetic mice.
J Ethnopharmacol,2017,196(1):47-57
|
被引
11
次
|
|
|
|
|
16.
Irimia J M. Impairedglucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
J Biol Chem,2010,285(17):12851-12861
|
被引
2
次
|
|
|
|
|
17.
Hao J. Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.
Eur J Pharmacol,2014,745:152-165
|
被引
11
次
|
|
|
|
|
18.
代紫阳. 施今墨对药配方对2型糖尿病大鼠肝脏胰岛素抵抗及PI3K/AKT/GSK-3β信号通路的影响.
山东医药,2020,60(14):35-38
|
被引
2
次
|
|
|
|
|
19.
Yu J. Thepathogenesis of nonalcoholic fatty liver disease: interplay between diet,gut microbiota,and genetic background.
Gastroenterol Res Pract,2016,28(1):1-14
|
被引
1
次
|
|
|
|
|
20.
Li Y C. Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis by activating LKB1/AMPK and AKT pathways.
Nutrients,2018,10(8):1024-1037
|
被引
2
次
|
|
|
|
|
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