环状RNA在糖尿病及其慢性并发症中的机制研究
Circular RNA in Diabetes and its Complications
查看参考文献65篇
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文摘
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环状RNA (circRNA)是一类特殊的非编码RNA,与线性RNA不同,circRNA是前信使RNA (pre-mRNA)通过反向剪接形成的封闭环状结构,表达高度稳定并广泛分布在真核生物中。circRNA主要通过充当微RNA (miRNA)海绵或与RNA结合蛋白结合发挥多种功能。circRNA可作为多种疾病的生物标志物。最新研究表明,circRNA在糖尿病和相关慢性并发症的发生发展中也起着重要作用。本综述旨在总结目前circRNA在糖尿病及其相关并发症发生发展中的作用及其机制的研究进展。 |
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其他语种文摘
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Circular RNA (circRNA) is a special group of non-coding RNA.Unlike linear RNA,circRNA is a closed circular structure formed by reverse splicing of pre-mRNA,with highly stable expression and wide distribution in eukaryotes.CircRNA has multiple functions by acting as microRNA sponges or binding with RNA-binding proteins.They can be used as biomarkers for many diseases.The latest research shows that circRNA plays a role in the pathogenesis of diabetes mellitus and the related chronic complications.In this review,we summarized the current progress and underlying mechanisms of circRNA in diabetes mellitus and the related complications. |
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来源
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中国医学科学院学报
,2022,44(3):521-528 【核心库】
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DOI
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10.3881/j.issn.1000-503X.13436
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关键词
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糖尿病
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糖尿病慢性并发症
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环状RNA
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地址
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苏州大学附属第二医院内分泌科, 江苏, 苏州, 215004
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1000-503X |
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学科
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临床医学 |
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文献收藏号
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CSCD:7249952
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