右美托咪定的心脏保护机制及其临床应用价值
Cardiac Protection Mechanism and Clinical Application of Dexmedetomidine
查看参考文献43篇
|
文摘
|
右美托咪定是一种α2肾上腺素受体激动剂,具有心脏保护作用,其相关分子机制仍在研究中。越来越多的证据表明右美托咪定在减少术后并发症、改善患者预后等方面具有重要的临床应用价值。本文结合目前已有研究总结右美托咪定的心脏保护机制,并综述右美托咪定在心血管手术围手术期的相关应用。 |
|
其他语种文摘
|
Dexmedetomidine is an α2 adrenoceptor agonist and has cardioprotective effect,the mechanism of which is being studied.Increasing studies have proved the clinical value of dexmedetomidine in reducing postoperative complications and improving the prognosis of patients.Therefore,this review summarizes the cardiac protection mechanism of dexmedetomidine based on the existing studies and expounds the application of dexmedetomidine in the perioperative period of cardiovascular surgery. |
|
来源
|
中国医学科学院学报
,2022,44(1):130-135 【核心库】
|
|
DOI
|
10.3881/j.issn.1000-503X.12895
|
|
关键词
|
右美托咪定
;
心脏保护
;
手术
;
围手术期
|
|
地址
|
1.
中国医学科学院北京协和医学院阜外医院心内科, 北京, 100037
2.
南加利福尼亚大学药学院药物经济学系, 美国, 洛杉矶, 90007
3.
南方医科大学第二临床医学院, 广州, 510515
4.
南方医科大学珠江医院麻醉科, 广州, 510515
5.
中山大学中山眼科中心, 眼科学国家重点实验室;;广东省眼科视觉科学重点实验室, 广州, 510060
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1000-503X |
|
学科
|
药学 |
|
基金
|
中国医学科学院医学与健康科技创新工程项目
|
|
文献收藏号
|
CSCD:7178361
|
参考文献 共
43
共3页
|
|
1.
Wang K. Effects of dexmedetomidine on perioperative stress,inflammation,and immune function:Systematic review and meta-analysis.
Br J Anaesth,2019,123(6):777-794
|
被引
13
次
|
|
|
|
|
2.
Castillo R L. Dexmedetomidine improves cardiovascular and ventilatory outcomes in critically III patients:Basic and clinical approaches.
Front Pharmacol,2019,10:1641
|
被引
2
次
|
|
|
|
|
3.
Tervonen M. Systematic review and meta-analysis found that intranasal dexmedetomidine was a safe and effective sedative drug during paediatric procedural sedation.
Acta Paediatr,2020,109(10):2008-2016
|
被引
3
次
|
|
|
|
|
4.
Uusalo P. Subcutaneously administered dexmedetomidine is efficiently absorbed and is associated with attenuated cardiovascular effects in healthy volunteers.
Eur J Clin Pharmacol,2018,74(8):1047-1054
|
被引
1
次
|
|
|
|
|
5.
Sun Y. Low-dose intramuscular dexmedetomidine as premedication:A randomized controlled trial.
Med Sci Monit,2014,20:2714-2719
|
被引
2
次
|
|
|
|
|
6.
Weerink M A S. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine.
Clin Pharmacokinet,2017,56(8):893-913
|
被引
54
次
|
|
|
|
|
7.
Okada H. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts.
Resuscitation,2007,74(3):538-545
|
被引
36
次
|
|
|
|
|
8.
Bunte S. Characteristics of dexmedetomidine postconditioning in the field of myocardial ischemia-reperfusion injury.
Anesth Analg,2020,130(1):90-98
|
被引
3
次
|
|
|
|
|
9.
Ibacache M. Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart.
Biochim Biophys Acta,2012,1822(4):537-545
|
被引
33
次
|
|
|
|
|
10.
Zhang J. Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury.
PLoS One,2019,14(7):e218726
|
被引
1
次
|
|
|
|
|
11.
Riquelme J A. Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.
Pharmacol Res,2016,103:318-327
|
被引
15
次
|
|
|
|
|
12.
He L. Dexmedetomidine preconditioning attenuates ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction.
Biomed Pharmacother,2019,114:108837
|
被引
1
次
|
|
|
|
|
13.
Srinivas D B. Comparison of subcutaneous dexmedetomidine versus clonidine as an adjuvant to spinal anesthesia:A randomized double blind control trial.
Local Reg Anesth,2019,12:29-36
|
被引
2
次
|
|
|
|
|
14.
Subramaniam B. Effect of intravenous acetaminophen vs. placebo combined with propofol or dexmedetomidine on postoperative delirium among older patients following cardiac surgery:The DEXACET randomized clinical trial.
JAMA,2019,321(7):686-696
|
被引
13
次
|
|
|
|
|
15.
Ortmann L A. Association between postoperative dexmedetomidine use and arrhythmias in infants after cardiac surgery.
World J Pediatr Congenit Heart Surg,2019,10(4):440-445
|
被引
1
次
|
|
|
|
|
16.
Zhao J N. Comparison of the morphine-sparing effect of intraoperative dexmedetomidine with and without loading dose following general anesthesia in multiple-fracture patients:A prospective,randomized,controlled clinical trial.
Medicine (Baltimore),2016,95(33):e4576
|
被引
1
次
|
|
|
|
|
17.
Zhang Z. Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists.
Nat Neurosci,2015,18(4):553-561
|
被引
16
次
|
|
|
|
|
18.
Lin Y. Meta-analysis of factors which influence delirium following cardiac surgery.
J Card Surg,2012,27(4):481-492
|
被引
10
次
|
|
|
|
|
19.
Shi C. Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients:A double-blinded,multi-center,randomizedstudy.
Clin Interv Aging,2019,14:571-575
|
被引
1
次
|
|
|
|
|
20.
Yapici N. Dexmedetomidine in cardiac surgery patients who fail extubation and present with a delirium state.
Heart Surg Forum,2011,14(2):E93-E98
|
被引
8
次
|
|
|
|
|
了解气象卫星更多信息，请访问