光交联羧甲基壳聚糖水凝胶的制备及药物缓释性能研究
Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release
查看参考文献32篇
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文摘
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羧甲基壳聚糖是一种壳聚糖衍生物,具有良好的生物相容性和可降解性,在生物医药领域具有广泛的应用。本研究合成一种可光交联的水溶性羧甲基壳聚糖衍生物。通过对羧甲基壳聚糖进行双键修饰,合成甲基丙烯酸缩水甘油酯改性的羧甲基壳聚糖(M-CMCS),并通过核磁共振氢谱(1 H-NMR)和傅里叶变换红外光谱(FT-IR)对M-CMCS的结构进行表征。通过光引发M-CMCS交联制备具有不同交联度的M-CMCS水凝胶。通过扫描电子显微镜(SEM)、流变仪和紫外-可见分光光度计(UV-Vis)分别对M-CMCS水凝胶的微观形态、黏弹性能、溶胀性能、酶促降解性能和体外药物释放性能进行了研究。结果表明:随着甲基丙烯酸缩水甘油酯与羧甲基壳聚糖的氨基摩尔比的增加,产物的接枝度逐渐增加。M-CMCS水凝胶具有高度孔隙化且孔隙之间相互连通的结构特点,孔径在1~20μm范围内。随着交联度的增大,M-CMCS水凝胶的溶胀比减小。M-CMCS水凝胶在溶菌酶作用下缓慢降解,随着交联度的增大,降解速率减慢。MCMCS水凝胶对抗癌药物吉西他滨具有缓释作用,药物释放时间可达4天。光交联M-CMCS水凝胶在药物释放及组织工程领域具有重要的应用前景。 |
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其他语种文摘
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Carboxymethyl chitosan is an important chitosan derivative with good biocompatibility and degradability,and has a wide range of biomedical applications.In this study,water-soluble carboxymethyl chitosan derivative that can be photo-crosslinked by UV irradiation was synthesized.Methacrylated carboxymethyl chitosan (M-CMCS) was synthesized by N-methacrylation of carboxymethyl chitosan (CMCS).The chemical structures of M-CMCS were characterized by ~~1H NMR and FT-IR.The M-CMCS hydrogels with different degrees of crosslinking was prepared by UV-triggered photo-crosslinking.The microscopic morphology,mechanical properties,swelling properties,enzymatic degradation properties and in vitro drug release behaviors of M-CMCS hydrogels were investigated by SEM,rheometer,and UV-Vis spectroscopy,respectively.The results show that the degree of methacrylation is gradually increased as the molar ratio of glycidyl methacrylate to carboxymethyl chitosan increases.M-CMCS hydrogels have the structure of high porosity and interconnected pores with the pore size of 1-20μm.The swelling ratio of M-CMCS hydrogels is decreased as the degree of crosslinking increases.M-CMCS hydrogel can be slowly degraded by lysozyme,and the degradation rate is decreased by increasing the degree of crosslinking.M-CMCS hydrogels show sustained release behavior for anticancer drug gemcitabine,and the drug release can be extended to 4 days.Photo-crosslinked M-CMCS hydrogels show great promise for drug release and tissue engineering. |
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来源
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材料工程
,2020,48(11):76-84 【核心库】
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DOI
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10.11868/j.issn.1001-4381.2020.000025
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关键词
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羧甲基壳聚糖
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水凝胶
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光交联
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药物缓释
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地址
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天津科技大学化工与材料学院, 天津, 300457
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天津理工大学材料科学与工程学院, 天津, 300457
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复旦大学, 聚合物分子工程国家重点实验室, 上海, 200433
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天津科技大学, 天津市海洋资源与化学重点实验室, 天津, 300457
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天津科技大学, 天津市制浆造纸重点实验室, 天津, 300457
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1001-4381 |
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学科
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化学 |
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基金
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2018年度天津市教委科研计划项目
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天津市海洋资源与化学重点实验室
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天津市制浆造纸重点实验室开放基金资助项目
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国家自然科学基金
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文献收藏号
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CSCD:6863734
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参考文献 共
32
共2页
|
|
1.
Ashraf S. Snapshot of phase transition in thermoresponsive hydrogel PNIPAM:role in drug delivery and tissue engineering.
Macromolecular Research,2016,24(4):297-304
|
被引
10
次
|
|
|
|
|
2.
Kim K. Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation.
Biomacromolecules,2013,14(10):3515-3522
|
被引
9
次
|
|
|
|
|
3.
张青松. 不同种类水凝胶对结晶紫染料的吸附性能研究.
材料工程,2011(12):20-24
|
被引
6
次
|
|
|
|
|
4.
Patel P. Thermosensitive hydrogel-based drug delivery system for sustained drug release.
Journal of Polymer Research,2019,26(6):131-141
|
被引
5
次
|
|
|
|
|
5.
Kim Y M. Temperature responsive chemical crosslinkable UV pretreated hydrogel for application to injectable tissue regeneration systemvia differentiations of encapsulated hMSCs.
Biomaterials,2017,112:248-256
|
被引
2
次
|
|
|
|
|
6.
Chen L. Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices.
Biomaterials,2004,25(17):3725-3732
|
被引
14
次
|
|
|
|
|
7.
Sacco P. A silver complex of hyaluronan-lipoate(SHLS12):synthesis,characterization and biological properties.
Carbohydrate Polymers,2016,136:418-426
|
被引
4
次
|
|
|
|
|
8.
Mukherjee D. Development and characterization of chitosan-based hydrogels as wound dressing materials.
Journal of Drug Delivery Science and Technology,2018,46:498-510
|
被引
3
次
|
|
|
|
|
9.
Dutta D. Development of silicone hydrogel antimicrobial contact lenses with Mel4peptide coating.
Optometry and Vision Science,2018,95(10):937-946
|
被引
2
次
|
|
|
|
|
10.
Huang J. Novel in situforming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery.
Carbohydrate Polymers,2018,186:54-63
|
被引
7
次
|
|
|
|
|
11.
Sutar P B. Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system.
Journal of Materials Science Materials in Medicine,2008,19(6):2247-2253
|
被引
7
次
|
|
|
|
|
12.
Zhang G. Dynamic supramolecular hydrogels:regulating hydrogel properties through self-complementary quadruple hydrogen bonds and thermo-switch.
ACS Macro Letters,2017,6(7):641-646
|
被引
5
次
|
|
|
|
|
13.
Guo Y. A self-healable and easily recyclable supramolecular hydrogel electrolyte for flexible supercapacitors.
Materials Chemistry A,2016,4(22):8769-8776
|
被引
1
次
|
|
|
|
|
14.
Li P. Improved mechanical and swelling behavior of the composite hydrogels prepared by ionic monomer and acid-activated laponite.
Applied Clay Science,2009,46(4):414-417
|
被引
4
次
|
|
|
|
|
15.
Hu Y. Degradable UV-crosslinked hydrogel for the controlled release of triclosan with reduced cytotoxicity.
Materials Science and Engineering:C,2016,67:151-158
|
被引
2
次
|
|
|
|
|
16.
陈阳娟. 可降解光交联聚酸酐与聚酰胺-甲基丙烯酰胺凝胶的合成及药物控释.
高等学校化学学报,2011,32(5):1194-1199
|
被引
2
次
|
|
|
|
|
17.
Cho I S. Synthesis and characterization of a new photo-crosslinkable glycol chitosan thermogel for biomedical applications.
Carbohydrate Polymers,2016,144:59-67
|
被引
3
次
|
|
|
|
|
18.
刘云鸿. UV光引发表面接枝两性离子水凝胶层的制备及抗细菌黏附性能.
高等学校化学学报,2013,34(6):1527-1535
|
被引
5
次
|
|
|
|
|
19.
Choi E J. UV-mediated synthesis of pNIPAM-crosslinked double-network alginate hydrogels:enhanced mechanical and shape-memory properties by metal ions and temperature.
Polymer,2018,149:206-212
|
被引
1
次
|
|
|
|
|
20.
Yuan L. Injectable photo crosslinked enhanced double-network hydrogels from modified sodium alginate and gelatin.
International Journal of Biological Macromolecules,2017,96:569-577
|
被引
12
次
|
|
|
|
|
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