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Long-term acupuncture treatment has a multitargeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study

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文摘 The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.
来源 Neural Regeneration Research ,2017,12(7):1159-1165 【核心库】
DOI 10.4103/1673-5374.211197
关键词 nerve regeneration ; neurodegeneration ; acupuncture ; Zusanli (ST36) ; Alzheimer's disease ; long-term treatment ; positron emission tomography ; rat ; mechanism ; targeting effect ; compensation ; multi-target regulation ; neural regeneration
地址

1. School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou  

2. Zhaoqing Medical College, Guangdong, Zhaoqing  

3. Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou  

4. Institute of High Energy Physics, Chinese Academy of Sciences, Key Laboratory of Nuclear Analytical Techniques,Chinese Academy of Sciences, Beijing  

5. Huarui Hospital of Southern Medical University, Guangdong, Guangzhou  

6. National Institute of Complementary Medicine, Western Sydney University, Australia, Penrith NSW

语种 英文
文献类型 研究性论文
ISSN 1673-5374
学科 中国医学
基金 supported by the National Basic Research Program of China (973 Program) ;  国家自然科学基金 ;  the Student's Platform for Innovation and Entrepreneurship Training Program of Southern Medical University of China ;  the Doctoral Foundation of Guangdong Medical University of China
文献收藏号 CSCD:6045748

参考文献 共 28 共2页

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引证文献 1

1 Yu Chaochao Effects of Acupuncture on Alzheimer's Disease:Evidence from Neuroimaging Studies Chinese Journal of Integrative Medicine,2019,25(8):631-640
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