帮助 关于我们

返回检索结果

微囊藻毒素生物学功能研究进展
Recent progress in research of the biological function of microcystins

查看参考文献57篇

文摘 我国淡水水体蓝藻水华的频繁发生已成为我国目前和今后长时期内面临的重大水环境问题.微囊藻(Microcystis)因其产生对人类健康具有危害的微囊藻毒素而尤其受到重视.研究者对构成蓝藻水华的主要种类、微囊藻毒素的毒性、毒理等方面的认识逐渐明晰,但对微囊藻毒素生物学功能的了解还相对较少.本文对微囊藻毒素的产生,尤其是近年来随着技术的发展在微囊藻毒素生物学功能方面的研究开展讨论:总结了微囊藻毒素可能作为化感物质、参与光合作用、在微囊藻的越冬或复苏中可能发挥的作用以及可能参与微囊藻群体形成及维持等4个方面的生物学功能;分析了微囊藻毒素作为信号分子的研究现状;探讨了全球气候变化及实验室模拟条件下微囊藻毒素产毒与无毒株的竞争,并对微囊藻毒素未来的研究热点及组学技术可能在其研究中的应用进行了展望.
其他语种文摘 Cyanobacterial bloom has become a frequent and problematic feature of many freshwater bodies over a wide geographical area, especially in China. Microcystis species are widely known for their production of the potent hepatotoxins called microcystins (MCs). While the toxicity of MCs on animals, including humans, has been well studied, the biological role of MCs on the organism from which they originate has not been clearly elucidated. In this paper, we summarized MCs production, especially MCs biological function with the development of technology in recent years. We reviewed and discussed the biological role of MCs in four aspects: Serving as allelochemical, involving in photosynthesis, taking part in the wintering and recovery of Microcystis and in the sustaining and formation of Microcystis colonies. In addition, MCs may act as signal molecule inside and outside Microcystis cells, relevant research has also been reviewed. Global climatic change which favour cyanobacterial blooms in eutrophic waters, may also influence the competition between MC-producing and non-MC-producing strains and their dominance. The study on the competition between MC-producing and non-MC-producing strains and the biological role of protein-bound MCs should be focused on for further investigation, fast development of variable -omics would favor the investigation.
来源 湖泊科学 ,2017,29(1):1-8 【核心库】
DOI 10.18307/2017.0101
关键词 微囊藻毒素 ; 生物学功能 ; 微囊藻 ; 蓝藻水华
地址

中国科学院水生生物研究所, 淡水生态与生物技术国家重点实验室, 武汉, 430072

语种 中文
文献类型 综述型
ISSN 1003-5427
学科 环境科学基础理论;环境污染及其防治
基金 国家自然科学基金项目
文献收藏号 CSCD:5904376

参考文献 共 57 共3页

1.  Kehr J. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol Microbiol,2006,59(3):893-906 被引 12    
2.  Kaplan A. The languages spoken in the water body (or the biological role of cyanobacterial toxins). Front Microbiol,2012,3:138 被引 4    
3.  宋立荣. 水华蓝藻产毒的生物学机制及毒素的环境归趋研究进展. 湖泊科学,2009,21(6):749-757 被引 16    
4.  Nishizawa T. Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcysin in Microcystis spp. J Biochem,1999,126(3):520-529 被引 20    
5.  Nishizawa T. Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin. J Biochem,2000,127(5):779-789 被引 16    
6.  Tillett D. Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806, an integrated peptide-polyketide synthetase system. Chem Biol,2000,7(10):753-764 被引 53    
7.  Utkilen H. Toxin production by Microcystis aeruginosa as a function of light in continuous cultures and its ecological significance. Appl Environ Microbiol,1992,58(4):13-21 被引 5    
8.  Wiedner C. Effects of light on the microcystin content of Microcystis strain PCC7806. Appl Environ Microbiol,2003,69(3):1475-1481 被引 17    
9.  Downing T G. Microcystin content of Microcystis aeruginosa is modulated by nitrogen uptake rate relative to specific growth rate or carbon fixation rate. Environ Toxicol,2005,20(3):257-262 被引 8    
10.  Harke M J. Global transcriptional responses of the toxic cyanobacterium, Microcystis aeruginosa, to nitrogen stress, phosphorus stress, and the growth on organic matter. PLoS One,2013,8(7):e69834 被引 8    
11.  Ginn H P. NtcA from Microcystis aeruginosa PCC7806 is autoregulatory and binds to the microcystin promoter. Appl Environ Microbiol,2010,76(13):4362-4368 被引 3    
12.  Kuniyoshi T M. 2-oxoglutarate enhances NtcA binding activity to promoter regions of the microcystin synthesis gene cluster. FEBS Lett,2011,585(24):3921-3926 被引 2    
13.  Sevilla E. Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806. Environ Microbiol,2008,10(10):2476-2483 被引 8    
14.  Alexova R. Iron uptake and toxin synthesis in the bloom-forming Microcystis aeruginosa under iron limitation. Environ Microbiol,2011,13(4):1064-1077 被引 15    
15.  Martin-Luna B. Fur from Microcystis aeruginosa binds in vitro promoter regions of the microcystin biosynthesis gene cluster. Phytochem,2006,67(9):876-881 被引 3    
16.  Martin-Luna B. Identification of a ferric uptake regulator from Microcystis aeruginosa PCC7806. FEMS Microbiol Lett,2006,254(1):63-70 被引 2    
17.  Orr P. Relationship between microcystin production and cell division rates in nitrogen-limited Microcystis aeruginosa cultures. Limnol Oceanogr,1998,43(7):1604-1614 被引 19    
18.  Long B M. Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate. Appl Environ Microbiol,2001,67(1):278-283 被引 14    
19.  Vezie C. Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations. Microb Ecol,2002,43(4):443-454 被引 39    
20.  Kaebernick M. Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide. Appl Environ Microbiol,2002,68(2):449-455 被引 5    
引证文献 13

1 江文静 以核糖体蛋白质鉴别铜绿微囊藻的应用分析 生物技术通报,2017,33(10):117-124
被引 1

2 徐潇颖 多壁碳纳米管分散固相萃取净化在测定水产品中3种微囊藻毒素的应用及与固相萃取法的比较 食品科学,2018,39(18):315-319
被引 0 次

显示所有13篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护:中国科学院文献情报中心
地址:北京中关村北四环西路33号 邮政编码:100190 联系电话:(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号