非人灵长类的光遗传学研究进展
The Progress of Optogenetic Studies in Nonhuman Primates
查看参考文献44篇
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文摘
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光遗传学是近十年来神经科学领域最受关注的一种神经调控技术.本文首先简要介绍了光遗传技术的工作原理,归纳了该技术在神经调控上的优势,并列出了一些可能的应用方向.随后指出,将光遗传技术与非人灵长类结合是推动该技术转化到临床治疗等领域的必要环节.本文系统回顾了光遗传技术在非人灵长类动物上取得的研究进展,并重点介绍了Dai等的工作.在总结这些工作的基础上,还分析了光遗传技术应用到灵长类研究所面临的一些挑战.最后,本文对筹划中的“中国脑计划”提出一些关于光遗传技术,尤其是在非人灵长类的立项建议. |
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其他语种文摘
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In the past decade,optogenetics is one of the most popular neuromodulation techniques in neuroscience. This review first briefly introduces the basic principle of optogenetics and summarizes its advantages in comparing with those traditional methods,and then lists some potential applications of this novel technique. In order to promote the conversion of optogenetic treatment in clinics,it is necessary to integrateoptogenetics with nonhuman primate study. This review then systematically looksback the progress of optogenetic studies in the nonhuman primates,and particularly highlights the work done by Dai et al.. In addition,this review also points out some challenges towards the development of optogenetics in the future. In the end,to advance the optogenetic-related studies,especially in the nonhuman primates,this review proposes some suggestions to the planning“Chinese Brain Initiative”. |
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来源
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生物化学与生物物理进展
,2016,43(4):354-360 【核心库】
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DOI
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10.16476/j.pibb.2016.0113
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关键词
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光遗传学
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非人灵长类
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神经调控
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脑功能
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地址
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中国科学院心理研究所, 脑与认知科学国家重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1000-3282 |
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学科
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普通生物学 |
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基金
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中国科学院心理研究所科研启动经费资助项目
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文献收藏号
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CSCD:5692085
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参考文献 共
44
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