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Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients

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文摘 Background: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin lAc at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37-4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, CI 0.92-0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
来源 Chinese Medical Journal ,2016,129(7):778-784 【核心库】
DOI 10.4103/0366-6999.178959
关键词 Obesity ; Risk Factor ; Type 2 Diabetes Mellitus ; Young
地址

1. Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, 100853  

2. Department of Endocrinology, Chinese People's Liberation Army 155 Hospital, Henan, Kaifeng, 475003  

3. Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010  

4. Department of Endocrinology, China-Japan Friendship Hospital, Beijing, 100029  

5. Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, Jinan, 250021  

6. Department of Endocrinology, Peking University Third Hospital, Beijing, 100191  

7. Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Liaoning, Shenyang, 110001  

8. Department of Endocrinology, China Meitan General Hospital, Beijing, 100028  

9. Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, 400038  

10. Department of Endocrinology, First Affiliated Hospital of Lanzhou University, Gansu, Lanzhou, 730000  

11. Department of Endocrinology, Beijing Yanhua Hospital, Beijing, 102500  

12. Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi, Taiyuan, 030001  

13. Department of Endocrinology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101100

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 医药、卫生
基金 was supported by National Science and Technology Major Project
文献收藏号 CSCD:5674625

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