天然黄酮类单体化合物抗焦虑作用研究进展
Advanced in studies on anxiolytic effects of natural flavonoids
查看参考文献26篇
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文摘
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焦虑症是严重危害人类健康的常见疾病之一,其发病机制十分复杂,国内外对焦虑症机制的研究多集中在神经递质、神经内分泌和免疫系统。近年来,对天然黄酮类单体化合物抗焦虑作用的研究日渐增多,但研究内容仍较少且不系统,研究方向仅仅涉及几种神经递质。该文将从黄酮类单体化合物抗焦虑的不同作用机制出发,对国内外天然黄酮类单体化合物抗焦虑作用及其机制、构效关系研究进行综述,为黄酮类单体化合物抗焦虑作用机制的深入研究,以及该类药物的开发研制提供理论依据。 |
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其他语种文摘
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Anxiety is one of the most common diseases endangering human health. Its pathogenesis is complex, the studies on the mechanisms of anxiety disorder are concentrated on neurotransmitter, neuroendocrine, immunologic system. Flavonoids are a kind of compounds which possess a variety of physiological activity, used in plenty of diseases. In recent years, researches of natural flavonoids on anti-anxiety were increasing, but contents were incomplete. It was just involved several neurotransmitters in research area. This paper is based on different anxiolytic effect mechanisms and structure-activity relationships of natural flavonoids, summarizing the researches of domestic and foreign, which can serve as a reference for further studies on anxiolytic effects of natural flavonoids. |
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来源
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中国中药杂志
,2016,41(1):38-44 【核心库】
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DOI
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10.4268/cjcmm20160108
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关键词
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天然黄酮类单体化合物
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抗焦虑活性
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抗焦虑机制
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神经递质
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构效关系
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地址
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1.
北京中医药大学中药学院, 北京, 100102
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中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1001-5302 |
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学科
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中国医学 |
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基金
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国家重大科技专项
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文献收藏号
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CSCD:5659284
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