羧胺三唑对大鼠佐剂性关节炎的治疗作用
Therapeutic Effect of Carboxyamidotriazole on Adjuvant Arthritis in Rats
查看参考文献14篇
|
文摘
|
目的研究羧胺三唑(CAI)对大鼠佐剂性关节炎(AA)的治疗作用。方法大鼠随机分为正常对照组、溶剂对照组(聚乙二醇400组和生理盐水组) 、CAI 3个剂量(10、20、40 mg /kg)组和阳性药地塞米松(Dex)组。采用弗氏完全佐剂诱导大鼠AA模型,进行关节炎评分、后肢X线摄片和组织病理学检查,检测大鼠炎症足爪组织中肿瘤坏死因子(TNF) -α、白细胞介素(IL) -1β和IL-6水平。结果CAI能明显降低AA大鼠的关节炎指数,促进其体重的恢复,改善AA大鼠后肢关节放射学和组织病理学损伤(P < 0.05或P < 0.01) 。CAI低、中、高剂量组和Dex组可显著降低TNF-α和IL-1β水平,CAI中、高剂量和Dex可显著降低IL-6水平(P < 0.05或P < 0.01) 。结论CAI对AA大鼠具有明显的治疗作用,其作用机制可能与其降低炎症部位的促炎细胞因子有关。 |
|
其他语种文摘
|
Objective To study the effect of carboxyamidotriazole (CAI) on adjuvant arthritis (AA) in rats. Methods The rats were randomly divided into normal group,two vehicle groups (polyethylene glycol 400 control and normal sodium control group),CAI-treated groups (10,20,and 40 mg /kg) and positive control dexamethasone group. Freund’s completed adjuvant was used to induce AA in rats. The arthritis index (AI) was scored,and X-ray check of the hind limbs and histopathological examination were performed. The levels of tumor necrosis factor (TNF) -α,interleukin (IL) -1β,and IL-6 in the inflamed paw tissues were measured. Results The administration of CAI significantly decreased the AI,restored the body weights,and ameliorated the radiological and histopathological features of joint destruction in AA rats (P < 0.05,P < 0.01). In addition, CAI reduced the TNF-α,IL-1β,and IL-6 levels in the inflamed paw tissues (P < 0.05,P < 0.01). Conclusion CAI has therapeutic effect on AA rats,which may be achieved by decreasing the pro-inflammatory cytokines at the site of inflammation. |
|
来源
|
中国医学科学院学报
,2016,38(1):49-54 【核心库】
|
|
DOI
|
10.3881/j.issn.1000-503x.2016.01.009
|
|
关键词
|
羧胺三唑
;
佐剂性关节炎
;
细胞因子
|
|
地址
|
中国医学科学院北京协和医学院基础医学研究所药理系, 北京, 100005
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1000-503X |
|
学科
|
药学 |
|
基金
|
国家自然科学基金
;
国家重大科技专项
|
|
文献收藏号
|
CSCD:5653266
|
参考文献 共
14
共1页
|
|
1.
Felson D T. The genetics of rheumatoid arthritis:new insights and implications.
JAMA,2015,313(16):1623-1624
|
被引
2
次
|
|
|
|
|
2.
Wasilenko W J. Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines.
Int J Cancer,1996,68(2):259-264
|
被引
4
次
|
|
|
|
|
3.
Moody T W. CAI inhibits the growth of small cell lung cancer cells.
Lung Cancer,2003,39(3):279-288
|
被引
6
次
|
|
|
|
|
4.
郭磊. 抗肿瘤药物羧胺三唑的抗炎镇痛作用.
中国医学科学院学报,2009,31(3):315-321
|
被引
4
次
|
|
|
|
|
5.
朱蕾. 羧胺三唑对角叉菜胶诱导急性炎症的抗炎作用.
中国临床药理学与治疗学,2013,18(6):601-606
|
被引
2
次
|
|
|
|
|
6.
Ahmed A S. Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.
Arthritis Rheum,2010,62(7):2160-2169
|
被引
4
次
|
|
|
|
|
7.
Zhu L. Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis.
Inflamm Res,2005,54(5):211-220
|
被引
26
次
|
|
|
|
|
8.
Hegen M. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis.
Ann Rheum Dis,2008,67(11):1505-1515
|
被引
12
次
|
|
|
|
|
9.
Gavrila B I. The efficiency of biologic therapy in a group of patients with rheumatoid arthritis.
J Med Life,2015,8(1):79-84
|
被引
2
次
|
|
|
|
|
10.
Wang D. The use of biologic therapies in the treatment of rheumatoid arthritis.
Curr Pharm Biotechnol,2014,15(6):542-548
|
被引
3
次
|
|
|
|
|
11.
Dayer J M. Therapeutic targets in rheumatoid arthritis:the interleukin-6 receptor.
Rheumatology (Oxford),2010,49(1):15-24
|
被引
23
次
|
|
|
|
|
12.
Garcia-Hernandez M H. Specific therapy to regulate inflammation in rheumatoid arthritis:molecular aspects.
Immunotherapy,2014,6(5):623-636
|
被引
4
次
|
|
|
|
|
13.
Figg W D. Pharmacokinetics of orally administered carboxyamido-triazole,an inhibitor of calcium-mediated signal transduction.
Clin Cancer Res,1995,1(8):797-803
|
被引
1
次
|
|
|
|
|
14.
Stadler W M. Successful implementation of the randomized discontinuation trial design:an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma-CALGB 69901.
J Clin Oncol,2005,23(16):3726-3732
|
被引
2
次
|
|
|
|
|
了解气象卫星更多信息，请访问