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Isolation of hemoglobin with metal–organic frameworks Y(BTC)(H_2O)_6

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文摘 The hierarchical metal–organic frameworks (MOFs), such as Y(BTC)(H_2O)_6, are prepared with yttrium nitrate and benzene-1,3,5-tricarboxylic acid at room temperature. The product is characterized by Fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The Y(BTC)(H_2O)_6 particles are sufficiently rigid for performing solid phase extraction and they exhibit favorable selectivity toward the adsorption of hemoglobin. The adsorption behavior of hemoglobin onto the Y(BTC)(H_2O)_6 fits the Langmuir adsorption model with a theoretical adsorption capacity of 555.6 mg g~(-1). An adsorption efficiency of 87.7% for 100 mgmL~(-1) hemoglobin in 1 mL sample solution (at pH 6.0) is achieved with 0.40 mg Y(BTC)(H_2O)_6. 77.3% of the retained hemoglobin is readily recovered using a 0.5% (m/v) SDS solution as the stripping reagent. Circular dichroism spectra indicated that the conformation of hemoglobin is maintained during the adsorption–desorption process. The MOFs material is applied for the isolation of hemoglobin from human blood and the purity of the obtained hemoglobin is further verified by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS–PAGE).
来源 Chinese Chemical Letters ,2015,26(12):1460-1464 【核心库】
DOI 10.1016/j.cclet.2015.10.013
关键词 Metal–organic frameworks ; Hemoglobin ; Solid-phase extraction ; Protein solation
地址

Research Center for Analytical Sciences, College of Sciences, Northeastern University, Shenyang, 110819

语种 英文
文献类型 研究性论文
ISSN 1001-8417
学科 化学;医药、卫生
基金 国家自然科学基金 ;  Fundamental Research Funds for the Central Universities
文献收藏号 CSCD:5605583

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引证文献 1

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