帮助 关于我们

返回检索结果

精神分裂症有无幻听患者静息态功能磁共振比率低频振荡振幅的研究
Schizophrenic patients with or without auditory hallucination in the study of fraction amplitude of low-frequency fluctuation of resting state functional magnetic resonance imaging

查看参考文献29篇

陈诚 1   王高华 1 *   王惠玲 1   蒋田仔 2   周媛 3   吴士豪 1   黄欢 1   邹寄林 1  
文摘 目的探讨有无幻听的精神分裂症患者静息态fMRI比率低频振荡振幅(fraction amplitude of low-frequency fluctuation,fALFF)的特征及幻听产生的神经影像机制。方法采用静息态功能磁共振fALFF研究方法,对49例有幻听的患者(幻听组)、23例无幻听的患者(非幻听组)及81名健康对照者(对照组),进行静息态fMRI扫描。计算fALFF的值,3组进行方差分析得出有差异的脑区,并分别进行两组之间的独立样本t检验,最后将幻听评分与差异脑区fALFF值进行相关分析。结果(1)3组fALFF值存在差异的脑区:双侧小脑后叶、左侧尾状核和豆状核、双侧额中回及前扣带回(AlphaSim校正,P<0.05,体素个数>21); (2)有差异脑区fALFF值的组间比较:右侧和左侧小脑后叶:与对照组(-1.10 ± 0.35、-1.26 ± 0.38)相比,幻听组(-0.83 ± 0.40 、-0.98 ± 0.50)和非幻听组(-0.55 ± 0.41、-0.62±0.40)fALFF值升高(t=-4.009、-3.603,均P<0.05);而幻听组与非幻听组相比,幻听组fALFF值降低(t=-2.782、-2.958,均P<0.05);左侧尾状核:与对照组相比,幻听组和非幻听组fALFF值增高(t=-4.51、-1.81,均P<0.05);左侧豆状核:与对照组(-0.32±0.40)相比,幻听组(0.05±0.52)fALFF值增高(t=-6.614,P<0.01)而非幻听组(-0.15±0.38)与对照组比较差异无统计学意义;左侧和右侧额中回:与非幻听组相比,幻听组(t=-4.051、-3.154)和对照组(t=-6.645、-5.535)fALFF值增高(均P<0.05);左侧和右侧前扣带回:与对照组相比,幻听组(t=3.898、5.004)和非幻听组(t=4.616、5.860)fALFF值降低(均P<0.05);(3)相关分析:幻听严重程度与左右侧小脑后叶fALFF值呈负相关(r=-0.401、-0.547,均P< 0.01);与左侧豆状核fALFF值呈正相关(r=0.311,P<0.05)但与左侧尾状核、双侧额中回及前扣带回无明显相关性。结论精神分裂症患者存在多个脑区的自发功能活动异常。伴有幻听的精神分裂症患者可能存在显著双侧小脑后叶及左侧豆状核的功能活动异常,为进一步揭示幻听产生的病理生理机制提供了神经影像基础。
其他语种文摘 Objective Using the fraction amplitude of low-frequency fluctuation (fALFF) of rest-stating fMRI to explore the characteristics of fALFF in schizophrenia with/without auditory hallucination and understand the pathological mechanism of brain function in schizophrenia with auditory hallucinations. Methods 49 schizophrenic patients (APG) with and 23 without auditory hallucination (NPG), 81 healthy volunteers (NC) were included in the study. All subjects underwent rest-stating fMRI. Values of fALFF were calculated in the tape limit ranging from 0.01 Hz to 0.08 Hz. A one-way analysis of covariance, with group as fixed factor (whole-brain corrected), was conducted and followed by post hoc pairwise comparisons. Meanwhile, pearson correlation analyses were performed to further assess the relationships between these different regions of fALFF values and the Hoffman scores in patients with auditory hallucinations. Result (1) There were different on fALFF values among 3 groups in bilateral cerebellum posterior lobe, the left caudate, the left lentiform nucleus, bilateral middle frontal gyrus, bilateral anterior cingulate (AlphaSim corrected, P<0.05, voxel>21). (2)The fALFF values:Bilateral cerebellum posterior lobe: compared with NC (-1.10±0.35,-1.26±0.38),both APG(-0.83±0.40,-0.98±0.50) and NPG(-0.55±0.41,-0.62±0.40)showed increased fALFF (t=- 4.009,- 3.603,both P<0.05), but APG showed decreased fALFF (t=-2.782, -2.958, both P<0.05) than NPG; The left caudate: compared with NC, both APG and NPG showed increased fALFF (t=-4.51,- 1.81,both P<0.05); The left lentiform nucleus: compared with NC (-0.32±0.40),APG (0.05±0.52) showed increased fALFF(t=-6.614,P<0.01), but NPG (-0.15±0.38) showed no difference; Bilateral middle frontal gyrus: compared with NPG, both APG (t=-4.051, -3.154) and NC (t=-6.645, -5.535) showed increased fALFF (all P<0.05); Bilateral anterior cingulate: Compared with NC, both APG (t=3.898, 5.004) and NPG (t=4.616, 5.860) showed decreased fALFF (all P<0.05). (3) Pearson correlation analyses showed that Hoffman score showed negatively correlated with bilateral cerebellum posterior lobe (r=-0.401, -0.547; both P<0.01)and positively correlated with the left lentiform nucleus (r= 0.311, P<0.05), but no relationship with bilateral middle frontal gyrus, bilateral anterior cingulate and the left caudate nucleus. Conclusion This study confirmed schizophrenia patients had abnormal spontaneous activity in multiple regions. Schizophrenia with auditory hallucinations may show abnormal activity in bilateral cerebellum posterior lobe and the left lentiform nucleus, which can help us to reveal the neuroimaging mechanism of auditory hallucinations.
来源 中华精神科杂志 ,2015,48(4):232-238 【核心库】
DOI 10.3760/cma.j.issn.1006-7884.2015.04.009
关键词 精神分裂症 ; 磁共振成像 ; 幻听 ; 比率低频振荡振幅
地址

1. 武汉大学人民医院精神科, 430000  

2. 中国科学院自动化研究所  

3. 中国科学院心理研究所

语种 中文
文献类型 研究性论文
ISSN 1006-7884
学科 神经病学与精神病学;外国民族医学
基金 国家自然科学基金 ;  湖北省自然科学基金
文献收藏号 CSCD:5483966

参考文献 共 29 共2页

1.  Zou Q H. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI:fractional ALFF. J Neurosci Methods,2008,172(1):137-141 被引 131 次    
2.  Bullmore E. Complex brain networks:graph theoretical analysis of structural and functional systems. Nat Rev Neurosci,2009,10(3):186-198 被引 205 次    
3.  Plaze M. Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients. Schizophr Res,2006,87(1/3):109-115 被引 4 次    
4.  Alba-Ferrara L. Voice identity recognition failure in patients with schizophrenia. J Nerv Ment Dis,2012,200(9):784-790 被引 5 次    
5.  Allen P. The hallucinating brain:a review of structural and functional neuroimaging studies of hallucinations. Neurosci Biobehav Rev,2008,32(1):175-191 被引 9 次    
6.  Chhabra S. Voice identity discrimination in schizophrenia. Neuropsychologia,2012,50(12):2730-2735 被引 5 次    
7.  David A S. Auditory hallucinations:phenomenology, neuropsychology and neuroimaging update. Acta Psychiatr Scand Suppl,1999,395:95-104 被引 6 次    
8.  Song X W. REST:a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One,2011,6(9):e25031 被引 103 次    
9.  Satterthwaite T D. An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. Neuroimage,2013,64:240-256 被引 8 次    
10.  Yan C G. A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics. Neuroimage,2013,76:183-201 被引 34 次    
11.  Buckner R L. Opportunities and limitations of intrinsic functional connectivity MRI. Nat Neurosci,2013,16(7):832-837 被引 15 次    
12.  史家波. 男性精神分裂症患者脑侧化与幻听的功能磁共振成像研究. 中华精神科杂志,2007,40(2):65-69 被引 2 次    
13.  Bluhm R L. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients:anomalies in the default network. Schizophr Bull,2007,33(4):1004-1012 被引 23 次    
14.  Zhou Y. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia. Schizophr Res,2008,100(1/3):120-132 被引 10 次    
15.  Mulert C. Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophrenia. Int J Psychophysiol,2011,79(1):55-63 被引 1 次    
16.  Bentaleb L A. Cerebral activity associated with auditory verbal hallucinations:a functional magnetic resonance imaging case study. J Psychiatry Neurosci,2002,27(2):110-115 被引 4 次    
17.  嵇利亚. 精神分裂症幻听患者初级听觉皮质的脑磁图研究. 中华精神科杂志,2008,41(3):148-151 被引 1 次    
18.  Andreasen N C. The role of the cerebellum in schizophrenia. Biol Psychiatry,2008,64(2):81-88 被引 8 次    
19.  Yeganeh-Doost P. The role of the cerebellum in schizophrenia:from cognition to molecular pathways. Clinics (Sao Paulo),2011,66(Suppl 1):71-77 被引 3 次    
20.  Hoekzema E. Enhanced neural activity in frontal and cerebellar circuits after cognitive training in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp,2010,31(12):1942-1950 被引 5 次    
引证文献 2 篇

1 陈峰 精神分裂症首次发病未用药患者药物治疗前后静息态脑功能低频振幅的变化特征 中华精神科杂志,2017,50(2):133-138
被引 2 次

2 朱义江 成人周围性面神经麻痹的静息态功能磁共振成像比率低频振幅的价值 中华医学杂志,2017,97(27):2081-2086
被引 1 次

显示所有2篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护：中国科学院文献情报中心
地址：北京中关村北四环西路33号 邮政编码：100190 联系电话：(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号