慢性进行性眼外肌麻痹和Kearns-Sayre综合征患者视网膜神经纤维层厚度测量及影响因素分析
Measurement and analysis of retinal nerve fiber layer thickness in chronic progressive external ophthalmoplegia and kearns-sayre syndrome
查看参考文献14篇
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文摘
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目的观察慢性进行性眼外肌麻痹(CPEO)和Kearns-Sayre综合征(KSS)患者视网膜神经纤维层(RNFL)厚度,分析其影响因素。方法经肌肉病理活检确诊的CPEO患者22例纳入研究。其中,男性7例,女性15例。平均年龄(29.09±13.40)岁;平均起病年龄(16.4±10.7岁)。平均病程(11.30± 7.30)年。22例患者中,CPEO患者18例(CPEO组);KSS患者4例(KSS组)。患者均行频域光相干断层扫描(SD-OCT)检查。选取左眼为受检眼,以视盘中心为圆心,直径为3.45 mm的环形扫描。扫描分为上方颞侧(ST)、颞上方(TU)、颞下方(TL)、下方颞侧(IT)、下方鼻侧(IN)、鼻下方(NL)、鼻上方(NU)、上方鼻侧(SN)。Pearson相关分析法分析RNFL厚度与患者起病时间、病程的相关性。结果22例患者视盘旁全周平均RNFL厚度为(101.5±14.4) μm。ST、TU、TL、IT、IN、NL、NU、SN平均RNFL厚度分别为(136.3±24.1)、(85.4±25.7)、(68.2±11.7)、(128.2±28.7)、(127.3 ±29.5)、(66.7±16.8)、(70.1± 17.6)、(122.9±20.2) μm。KSS组视盘旁全周及各象限平均RNFL厚度均较CPEO组低,但差异无统计学意义(P>0.05)。相关性分析结果显示,RNFL厚度下降与起病年龄无相关性(r=-0.306,P = 0.11);与病程呈负相关(r=-0.518,P = 0.03),尤其是鼻侧4个象限RNFL厚度与病程呈负相关(IN: r = -0.555, P=0.01;NL: r=-0.630,P = 0.00;NU: r=-0.559,P = 0.01, SN: r=-0.557,P = 0.01)。 结论CPEO、KSS患者RNFL厚度差异无统计学意义;RNFL厚度特别是鼻侧RNFL厚度与病程呈负相关。 |
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其他语种文摘
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Objective To determine the retinal nerve fiber layer thickness (RNFLT) of chronic progressive external ophthalmoplegia (CPEO) and kearns-sayre syndrome (KSS) patients using spectraldomain optical coherence tomography (SD-OCT) and to analyze the potential influence factors for RNFLT of these patients. Methods 18 CPEO and 4 KSS (CPEO with retinitis pigmentosa and cardiac block) patients, all were muscle biopsy confirmed, were included in this study. There were 7 males and 15 females, the average age was (29.09 ± 13.40) years, the average onset age was (16.4 + 10.7) years and the average disease duration was (11.30±7.30) years. All the patients underwent SD-OCT examination for the left eye, the peripapillary RNFL thickness was measured using the Spectralis 3.45 mm circle scan protocol. 8 quadrants were scanned including superior temporal (ST), temporal upper (TU), temporal lower (TL), inferior temporal (IT),inferior nasal (IN),nasal lower (NL), nasal upper (NU) and superior nasal (SN). The relationship between RNFLT and onset time, disease duration was analyzed by Pearson correlation analysis. Results The average RNFLT of ST, TU, TL, IT, IN, NL, NU, SN in the 22 patients were (136.3±24.1),(85.4±25.7),(68.2± 11.7),(128.2±28.7), (127.3±29.5), (66.7±16.8), (70.1 ± 17.6) μm,respectively. The circumferential average RNFLT was (101.5 ± 14.4) μm. There was no significant difference between the KSS group and CPEO group (P>0.05). The decrease of the circumferential RNFLT had no relationship with the onset age (r = - 0.306,P = 0.11),but a negative relationship with the disease course (r=-0.518,P = 0.03). There were negative relationships between the disease course and RNFLT of 4 nasal quadrants (IN:r=-0.555, P=0.01, NL: r=-0.630, P = 0.00, NU: r=-0.559,P = 0.01,SN: r=-0.557,P = 0.01). Conclusion There is no difference in RNFLT of patients with CPEO and KSS. There is a negative relation between RNFLT (especially RNFLT of 4 nasal quadrants) and disease course. |
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来源
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中华眼底病杂志
,2015,31(4):348-351 【核心库】
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DOI
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10.3760/cma.j.issn.1005-1015.2015.04.009
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关键词
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眼肌麻痹,慢性进行性外侧
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卡恩斯-塞尔综合征
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体层摄影术,光学相干
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地址
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1.
北京大学第一医院眼科, 100034
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北京大学第一医院神经内科, 100034
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1005-1015 |
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学科
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眼科学 |
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文献收藏号
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CSCD:5483608
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参考文献 共
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