低氧信号传导途径与鱼类低氧适应
查看参考文献88篇
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文摘
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低氧信号传导途径是从线虫到哺乳动物都十分保守的一个细胞信号传导途径系统,它对于维持后生动物的氧稳态至关重要.低氧诱导因子是该信号传导系统中最为关键的因子.对低氧诱导因子的调控是对低氧信号途径网络进行有效调控的主要方式.由于鱼类生存的水环境溶氧量的变化很大,在长期进化过程中,鱼类演化出适应不同浓度溶氧水环境的物种,并发展出千差万别的低氧适应策略.对鱼类低氧适应策略及其低氧适应机制的研究,对于认识鱼类物种形成的动因和培育耐低氧鱼类新品种具有十分重要的意义.本文在总结低氧信号传导及其调控机制研究进展的基础上,综述了鱼类低氧信号途径、低氧适应策略、低氧信号途径网络调控等方面研究的慨况. |
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来源
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中国科学. 生命科学
,2014,44(12):1227-1235 【核心库】
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关键词
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低氧
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低氧诱导因子
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PHDs
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pVHL
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FIH
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鱼类
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地址
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中国科学院水生生物研究所, 武汉, 430072
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1674-7232 |
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学科
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水产、渔业 |
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基金
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国家973计划
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中国科学院战略性先导科技专项
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国家自然科学基金
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文献收藏号
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CSCD:5328361
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参考文献 共
88
共5页
|
|
1.
Semenza G L. Hypoxia-inducible factors in physiology and medicine.
Cell,2012,148:399-408
|
被引
88
次
|
|
|
|
|
2.
Semenza G L. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.
Annu Rev Phytopathol,2014,9:47-71
|
被引
44
次
|
|
|
|
|
3.
Majmundar A J. Hypoxia-inducible factors and the response to hypoxic stress.
Mol Cell,2010,40:294-309
|
被引
89
次
|
|
|
|
|
4.
Dunwoodie S L. The role of hypoxia in development of the Mammalian embryo.
Dev Cell,2009,17:755-773
|
被引
24
次
|
|
|
|
|
5.
Schofield C J. Oxygen sensing by HIF hydroxylases.
Nat Rev Mol Cell Biol,2004,5:343-354
|
被引
40
次
|
|
|
|
|
6.
Bickler P E. Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability.
Annu Rev Physiol,2007,69:145-170
|
被引
27
次
|
|
|
|
|
7.
Greer S N. The updated biology of hypoxia-inducible factor.
EMBO J,2012,31:2448-2460
|
被引
25
次
|
|
|
|
|
8.
Aragones J. Oxygen sensors at the crossroad of metabolism.
Cell Metab,2009,9:11-22
|
被引
9
次
|
|
|
|
|
9.
Kaelin W G. Von Hippel-Lindau disease.
Annu Rev Pathypathol,2007,2:145-173
|
被引
8
次
|
|
|
|
|
10.
Rius J. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Nature,2008,453:807-811
|
被引
59
次
|
|
|
|
|
11.
Flugel D. Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner.
Mol Cell Biol,2007,27:3253-3265
|
被引
6
次
|
|
|
|
|
12.
Ryu J H. Hypoxia-inducible factor alpha subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.
J Biol Chem,2011,286:6963-6970
|
被引
4
次
|
|
|
|
|
13.
Sang N. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.
Mol Cell Biol,2002,22:2984-2992
|
被引
6
次
|
|
|
|
|
14.
Mehta R. Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Science,2009,324:1196-1198
|
被引
4
次
|
|
|
|
|
15.
Chen D. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
PLoS Genet,2009,5:e1000486
|
被引
5
次
|
|
|
|
|
16.
Zhong L. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Cell,2010,140:280-293
|
被引
41
次
|
|
|
|
|
17.
Lim J H. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
Mol Cell,2010,38:864-878
|
被引
29
次
|
|
|
|
|
18.
Dioum E M. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.
Science,2009,324:1289-1293
|
被引
15
次
|
|
|
|
|
19.
Gomes A P. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Cell,2013,155:1624-1638
|
被引
36
次
|
|
|
|
|
20.
Hubbi M E. Sirtuin-7 inhibits the activity of hypoxia-inducible factors.
J Bioll Chem,2013,288:20768-20775
|
被引
7
次
|
|
|
|
|
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