大鼠注意定势转移任务模型的深入研究:种系和检测程序的影响
Further Study on the Attentional Set-shifting Task in Rats: Effects of Strain and Testing Protocol
查看参考文献31篇
文摘
|
注意定势转移任务(attentional set-shifting task, AST)可用于特异性检测啮齿类动物前额叶皮层及其皮层下神经通路介导的认知灵活性, 是目前研究认知灵活性及其障碍神经基础的重要模型。本研究系统调查了大鼠种系和检测程序差异对 AST 结果的影响。通过比较 Wistar 和 Sprague Dawley(SD)两个种系大鼠在七阶段和五阶段两种 AST 检测程序中的认知表现, 研究发现:(1)SD 和 Wistar 大鼠前额叶认知功能存在差异,后者的总体认知表现优于前者。尤其是 Wistar 大鼠在逆反学习阶段的达标训练次数及错误率显著低于 SD大鼠, 表明 Wistar 大鼠具有更高的策略转换灵活性。(2)在 AST 测试中逆反学习和外维度定势转移是认知灵活性评价的核心指标。这两种认知转换过程分别以前期策略和注意定势建立为基础。结果显示在两种 AST检测程序中 Wistar 和 SD 大鼠在逆反学习和 /或外维度定势转移等复杂学习阶段的达标训练次数和错误率均高于其它简单关联学习阶段, 表明在目前实验条件下大鼠均表现出定势形成和转换困难的反应模式, 不同认知反应间的结构关系具有稳定性。这些结果提示大鼠前额叶皮质介导的认知灵活性存在种系差异, AST 各阶段认知反应间的结构效度不受目前使用的大鼠种系和检测程序差异的影响, 扩展了对 AST 模型的认识。 |
其他语种文摘
|
Attentional set-shifting task (AST) is a newly developed rodent-based model that can be used to specifically evaluate cortically-mediated cognitive flexibility. The AST has been increasingly used to investigate the neural basis underlying cognitive flexibility and related disorders. In the present study, we investigated the effects of strain and testing protocol on cognitive function by comparing the performance during different cognitive stages in the AST, between Sprague-Dawley (SD) and Wistar rats, and between a seven-stage and five-stage AST. Our data showed differences in cortically-mediated cognitive function between SD and Wistar rats when they were tested in both seven-stage and five-stage AST. In general, Wistar rats exhibited better performance in each stage of the AST compared with SD rats. Especially in the reversal learning (RL) stage, Wistar rats required fewer trials to reach the criterion and lower error rates compared with SD rats, suggesting better cognitive flexibility in strategy shifting. In contrast, the reactive pattern between different cognitive stages (simple discrimination, SD; compound discrimination, CD; intra-dimensional shifting, IDS; reversal learning, RL; extra-dimensional shifting, EDS) in the AST did not significantly differ by strain or testing protocol. Theoretically, there is a general response pattern across these cognitive stages, namely, more trials to reach criterion and/or higher error rates are generally seen during higher complexity learning stages (i.e. RL and EDS) than in simpler learning stages (i.e. SD and CD), which is a prerequisite for the interpretation of performance in the RL and EDS in terms of strategy and attentional set-shifting. Consistent with this, we found that both SD and Wistar rats required more trials to reach criterion and showed higher error rates during RL and/or EDS stages than other stages in both the five-stage and seven-stage AST, demonstrating a stable reactive pattern of set establishment and set shifting in the AST. These results suggest that there are strain differences in cortically-mediated cognitive flexibility in rats, and constructive relationship across different cognitive components in the AST is stable across rat strain and testing protocol. These findings extend the extant knowledge of the AST model and provide a behavioral basis for the selection of experimental animal and testing protocols for the AST in further studies. |
来源
|
心理学报
,2014,46(12):1805-1813 【核心库】
|
关键词
|
认知灵活性
;
注意定势转移任务
;
种系差异
;
逆反学习
;
外维度定势转移
|
地址
|
1.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
2.
北京大学心理系, 北京, 100871
|
语种
|
中文 |
文献类型
|
研究性论文 |
ISSN
|
0439-755X |
学科
|
社会科学总论 |
基金
|
中国科学院项目
;
中国科学院心理健康重点实验室,中国科学院心理研究所
;
国家自然科学基金
|
文献收藏号
|
CSCD:5309317
|
参考文献 共
31
共2页
|
1.
Allison C. Nicotine improves performance in an attentional set shifting task in rats.
Neuropharmacology,2013,64:314-320
|
被引
2
次
|
|
|
|
2.
Andrews J S. Performance of four different rat strains in the autoshaping, two-object discrimination, and swim maze tests of learning and memory.
Physiology & Behavior,1995,57(4):785-790
|
被引
1
次
|
|
|
|
3.
Anokhin A P. Genetic influences on frontal brain function: WCST performance in twins.
Neuroreport,2003,14(15):1975-1978
|
被引
1
次
|
|
|
|
4.
Beck A T. The evolution of the cognitive model of depression and its neurobiological correlates.
American Journal of Psychiatry,2008,165(8):969-977
|
被引
32
次
|
|
|
|
5.
Birrell J M. Medial frontal cortex mediates perceptual attentional set shifting in the rat.
Journal of Neuroscience,2000,20(11):4320-4324
|
被引
10
次
|
|
|
|
6.
Bissonette G B. Reversal learning and attentional set-shifting in mice.
Neuropharmacology,2012,62(3):1168-1174
|
被引
2
次
|
|
|
|
7.
Bondi C O. Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alpha1-adrenergic receptors in medial prefrontal cortex.
Progress in Neuro-psychopharmacology & Biological Psychiatry,2010,34(6):913-923
|
被引
2
次
|
|
|
|
8.
Bondi C O. Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment.
Neuropsychopharmacology,2008,33(2):320-331
|
被引
14
次
|
|
|
|
9.
Brimberg L. Strain differences in 'compulsive' lever-pressing.
Behavioural Brain Research,2007,179(1):141-151
|
被引
1
次
|
|
|
|
10.
Brown V J. Rodent models of prefrontal cortical function.
Trends in Neurosciences,2002,25(7):340-343
|
被引
4
次
|
|
|
|
11.
Burnham K E. Fos expression in the brains of rats performing an attentional set-shifting task.
Neuroscience,2010,171(2):485-495
|
被引
1
次
|
|
|
|
12.
Cain R E. Atomoxetine facilitates attentional set shifting in adolescent rats.
Developmental Cognitive Neuroscience,2011,1(4):552-559
|
被引
1
次
|
|
|
|
13.
Chen K C. Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set-shifting.
European Journal of Neuroscience,2004,20(4):1081-1088
|
被引
2
次
|
|
|
|
14.
Colacicco G. Attentional set-shifting in mice: modification of a rat paradigm, and evidence for strain-dependent variation.
Behavioral Brain Research,2002,132(1):95-102
|
被引
1
次
|
|
|
|
15.
Durstewitz D. Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning.
Neuron,2010,66(3):438-448
|
被引
2
次
|
|
|
|
16.
Floresco S B. Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure.
Behavioral Brain Research,2008,190(1):85-96
|
被引
3
次
|
|
|
|
17.
Fox M T. Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortex.
Journal of Neuroscience,2003,23(2):676-681
|
被引
2
次
|
|
|
|
18.
Fuzik J. Fundamental interstrain differences in cortical activity between Wistar and Sprague-Dawley rats during global ischemia.
Neuroscience,2013,228:371-381
|
被引
1
次
|
|
|
|
19.
Harker K T. Place and matching-to-place spatial learning affected by rat inbreeding (Dark-Agouti, Fischer 344) and albinism (Wistar, Sprague-Dawley) but not domestication (wild rat vs. Long-Evans, Fischer-Norway).
Behavioural Brain Research,2002,134(1/2):467-477
|
被引
1
次
|
|
|
|
20.
Hilti C C. Sustained attention and planning deficits but intact attentional setshifting in neuroleptic-naive first-episode schizophrenia patients.
Neuropsychobiology,2009,61(2):79-86
|
被引
1
次
|
|
|
|
|