LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study
查看参考文献17篇
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文摘
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A rapid and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) method for the determination of cefotetan in human plasma was developed and validated. After the protein precipitation of sample with acetonitrile, the analyte and internal standard(IS), tramadol, were separated on a Zorbax XDB C_8 column using acetonitrile/1%(volume fraction) formic acid(volume ratio 35:65, pH=2.5) as mobile phase at a flow rate of 1.0 mL/min with a 1:1 split. The detection was performed by electrospray ionization with positive ion mode, followed by multiple reaction monitoring of the transitions for cefotetan at m/z 576.3→460.2(quantifier) and m/z 576.3→432.2(qualifier) and for IS at m/z 264.1→58.1. Cefotetan and IS were eluted at 1.86 and 1.87 min, respectively. The assay was linear over the concentration range of 0.1―100 μg/mL for 20 μL of human plasma only with intra- and inter-day precisions(expressed as the relative standard deviation) of less than 6.62% and accuracies(as relative error) of ±1.31%. The method was applied to the pharmacokinetic study of a 1-h intravenous infusion of 1.0 g of cefotetan disodium for human volunteers(n=6). |
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来源
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Chemical Research in Chinese Universities
,2014,30(6):900-904 【核心库】
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DOI
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10.1007/s40242-014-4116-9
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关键词
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Cefotetan
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Liquid chromatography-tandem mass spectrometry(LC-MS/MS)
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Pharmacokinetics
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Human plasma
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地址
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1.
College of Life Science, Jilin University, Changchun, 130012
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School of Pharmaceutical Sciences, Jilin University, Changchun, 130021
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School of Pharmacy, University of Otago, New Zealand, Dunedin, 9054
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The Second Clinical Hospital Affiliated to Chinese Medical University, Shenyang, 110004
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1005-9040 |
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学科
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化学 |
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基金
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国家自然科学基金
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国家“211工程”项目“高等学校仪器设备和优质资源共享系统”资助
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文献收藏号
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CSCD:5301737
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参考文献 共
17
共1页
|
|
1.
Cho A.
Korean Journal of Critical Care Medicine,2012,27:126
|
被引
1
次
|
|
|
|
|
2.
Yano K.
Jpn. J. Antibiot,1982,35:438
|
被引
1
次
|
|
|
|
|
3.
Gribble M.
Can. Med. Assoc. J,1994,151:537
|
被引
1
次
|
|
|
|
|
4.
Singh A.
International Journal of Electrochemical Science,2013,8:10903
|
被引
1
次
|
|
|
|
|
5.
Aoyama R.
Jpn. J. Antibiot,1983,36:1191
|
被引
1
次
|
|
|
|
|
6.
Aso K.
Jpn. J. Antibiot,1983,36:1295
|
被引
1
次
|
|
|
|
|
7.
Chimura T.
Jpn. J. Antibiot,1983,36:2450
|
被引
1
次
|
|
|
|
|
8.
Maculotti L.
Minerva. Chir,1995,50:121
|
被引
1
次
|
|
|
|
|
9.
Chapman S J.
Am. J. Obstet. Gynecol,1997,177:831
|
被引
2
次
|
|
|
|
|
10.
Itani K M.
New Engl. J. Med,2006,355:2640
|
被引
2
次
|
|
|
|
|
11.
Guibert J.
J. Antimicrob. Chemother,1983,11(Suppl):201
|
被引
3
次
|
|
|
|
|
12.
Adam H K.
J. Antimicrob. Chemother,1983,11(Suppl):193
|
被引
2
次
|
|
|
|
|
13.
Pehourcq F.
J. Chromatogr. A,1998,812:159
|
被引
6
次
|
|
|
|
|
14.
Shi S.
Clin. Ther,2010,32:1832
|
被引
5
次
|
|
|
|
|
15.
Su M X.
Eur. J. Drug Metab. Ph,2011,36:223
|
被引
3
次
|
|
|
|
|
16.
Lin J.
Sci. Sin. Chim,2010,40:75
|
被引
2
次
|
|
|
|
|
17.
Liu Y.
J. Huazhong U. Sci-Med,2012,32:779
|
被引
1
次
|
|
|
|
|
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