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Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives

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文摘 Eleven novel triterpenoid saponins, N-substituted-?-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.
来源 Chemical Research in Chinese Universities ,2014,30(4):639-643 【核心库】
DOI 10.1007/s40242-014-3522-3
关键词 N-Substituted glucosamine-bearing triterpenoid saponin ; Tumor cytotoxicity ; Oleanolic acid
地址

Shenyang Pharmaceutical University, Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang, 110016

语种 英文
文献类型 研究性论文
ISSN 1005-9040
学科 化学
基金 国家自然科学基金 ;  the PhD Scientific Research Opening Foundation Projects of Liaoning Province of China
文献收藏号 CSCD:5214902

参考文献 共 17 共1页

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引证文献 2

1 Chen Qing Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities Chemical Research in Chinese Universities,2016,32(5):792-796
被引 4

2 Li Fengran Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives Chemical Research in Chinese Universities,2016,32(6):938-942
被引 1

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