OCT前节模块测量的上下泪河数值与干眼的相关性
Correlation between measurement of tear meniscus by anterior segment module of OCT with dry eye signs and symptoms
查看参考文献12篇
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文摘
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背景干眼是常见的眼表疾病,光学相干断层扫描(OCT)前节模块可实现对泪河进行直接和精确的检测.目的用OCT前节模块对上下泪河进行测量,并分析测量结果与干眼症状和体征的相关性.方法采用回顾性系列病例观察方法,收集2010年9-10月在北京大学第一医院眼科就诊的符合眼表疾病指数问卷(OSDI)评分>20分的干眼患者36例,使用OCT前节模块测量平视状态时上下泪河的高度(U/LTMH,μm)、深度(U/LTMD,μm)和泪三角面积(U/LMA,mm~2);对患者行泪膜干涉成像仪、泪膜破裂时间(BUT)、角膜荧光素钠(Fl)染色、结膜丽丝胺绿染色、Schirmer Ⅰ试验(SⅠt)检查.采用Spearman秩相关分析法评估OCT前节模块测量的泪河参数与患者干眼相关症状体征之间的相关性.结果本组患者平均UTMH为(232±56) μm,平均UTMD(156±53)μm,平均UMA为(0.021±0.008) mm~2,LTMH平均为(222±72) μm,平均LTMD为(163±65) μm,平均LMA为(0.020±0.006) mm~2,测量的上下泪河高度、深度接近,差异均无统计学意义(目河高度:t=0.530,P>0.05;泪河深度:t=0.650,P>0.05;泪河高度:t=1.010,P>0.05).泪河各参数与OSDI评分、泪膜干涉分析成像仪分析结果间无明显相关性;UTMH、UTMD、UMA与BUT均呈正相关(r=0.46,P=0.01;r=0.40,P=0.02;r=0.43,P=0.01);LTMH、LTMD、LMA与BUT均呈正相关(r=0.61,P=0.00;r=0.64,P=0.00;r=0.64,P=0.00),与SⅠt结果均呈正相关(r=0.54,P=0.02;r=0.46,P=0.01;r=0.55,P=0.01),而与角膜荧光素染色评分均呈负相关(r=-0.37,P=0.04;r=-0.37,P=0.04;r=-0.41,P=0.05),与结膜染色评分亦均呈负相关(r=-0.56,P=0.01;r=-0.37,P=0.04;r=-0.47,P=0.00).结论OCT前节模块可用于对上下泪河进行客观和非侵入性测量,其测量结果与BUT、角膜荧光素钠染色、结膜丽丝胺绿染色和SⅠt结果均有相关性,可作为干眼诊断的有效辅助工具. |
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其他语种文摘
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Background Dry eye is the most common ocular surface disease.Anterior segment pattern of optical coherent tomography (OCT) is able to be used to assess the tear meniscus directly and accurately.Objective This study was to evaluate the correlation between measuring outcomes of tear meniscus by anterior segment module of OCT with signs and symptoms of dry eye.Methods A retrospective serial cases-observational study was designed.Thirty-six patients who completed Ocular Surface Disease Index (OSDI) and got a score more than 20 were enrolled in the First Hospital of Peking University from September to October,2010 under the informed consent.The upper and lower tear meniscus height (U/LTMH,μm),depth (U/LTMD,μm) and cross sectional area (U/LMA,mm~2) were measured with the anterior segment module of OCT (RTVue.pitch).A series of clinical tests were performed,including tear film interferometry,break-up time (BUT),fluorescein corneal staining,lissamine green conjunctival staining and Schirmer Ⅰ test (S Ⅰ t).The correlations of measuring outcomes of tear meniscus by anterior segment module of OCT with dry eye-related examinations were analyzed with Spearman correlation coefficients.Results The values of UTMH,UTMD,UMA were (232±56) μm,(156±53) μm,(0.021 ±0.008) mm~2,respectively,and the values of LTMH,LTMD,LMA were (222 ± 72) μm,(163 ± 65) μm,(0.020 ± 0.006) mm~2,respectively.No significant differences were found in the measuring values between the upper and the lower tear meniscus (all at P>0.05).The quantitative values of tear meniscus were not significantly correlated with the OSDI scores or tear film interferometry grade.Significant correlations were seen between UTMH,UTMD,UMA and BUT (r=0.46,P=0.01;r=0.40,P=0.02;r=0.43,P=0.01).LTMH,LTMD,LMA were positively correlated with BUT (r=0.61,P=0.00;r=0.64,P=0.00;r=0.64,P=0.00) and S Ⅰ t (r=0.54,P=0.02;r=0.46,P=0.01;r=0.55,P=0.01) as well as negatively correlated with fluorescein cornealstaining (r=-0.37,P=0.04;r=-0.37,P=0.04;r=-0.41,P =0.05) and lissamine green conjunctival staining (r =-0.56,P =0.01; r =-0.37,P =0.04; r =-0.47,P =0.00).Conclusions Anterior segment module of OCT is an effective approach to the measurement of tear meniscus.The measuring outcomes of anterior segment of OCT are associated with dry eye-related signs. |
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来源
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中华实验眼科杂志
,2014,32(6):541-545 【扩展库】
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DOI
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10.3760/cma.j.issn.2095-0160.2014.06.013
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关键词
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体层摄影术
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光学相干断层扫描术
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前节模块
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泪河
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干眼
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地址
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北京大学第一医院眼科, 100034
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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2095-0160 |
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学科
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眼科学;特种医学 |
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文献收藏号
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CSCD:5165904
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参考文献 共
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